Role of chromium supplementation in Indians with type 2 diabetes mellitus

Ghosh, Debjani; Bhattacharya, Basudev; Mukherjee, Biswajit; Manna, Byomkesh; M, Sinha; Chowdhury, Jyothi; Chowdhury, Subhankar

doi:10.1016/s0955-2863(02)00220-6

Cited by 129 publications

(102 citation statements)

References 68 publications

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“…This is similar to observations reported from earlier studies [11][12][13][14]. However, the minimum serum chromium value found in our study was lower than the lowest value reported by a number of studies carried out in the Western countries [13,14].…”

Section: Discussionsupporting

confidence: 91%

Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic Control

Rajendran

Manikandan

Nair

et al. 2015

JCDR

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Section: Discussionsupporting

confidence: 91%

Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic Control

Rajendran

Manikandan

Nair

et al. 2015

JCDR

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“…Abbreviations: Cr, chromium; IGT, impaired glucose tolerance; RCTs, randomized controlled trials. 22 Cefalu et al (2010) 23 Chen et al (2014) 24 Crawford et al (1999) 25 Evans (1989) 26 Ghosh et al (2002) 27 Gunton et al (2005) 28 Grant and McMullen. (1982) 29 Grant et al (1997) 30 Hermann et al (1998) 31 Hermann et al (1994) 32 Jain et al (2012) 40 Lee and Reasner (1994) 41 Li et al (1992) 42 Li (1994) 43 45 Martinez et al (1985) 46 Mossop (1983) 47 Offenbacher and Pi-Sunyer (1980) 48 Offenbacher et al (1985) 49 Pasman et al (1997) 50 Pei et al (2006) 51 Rabinovitz et al (1983) 52 Rabinovitz et al (2004) 53 Racek et al (2006) 54 Riales et al (1981) 55 Singer and Geohas (2006) 56 Sharma et al (2011) 57 Sherman et al (1968) 58 Thomas and Gropper (1996) 59 Urberg and Zemel (1987) …”

Section: Studies Measuring Hba1cmentioning

confidence: 99%

Chromium supplements for glycemic control in type 2 diabetes: limited evidence of effectiveness

2016

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Some adults with type 2 diabetes mellitus (T2DM) believe that chromium-containing supplements will help control their disease, but the evidence is mixed. This narrative review examines the efficacy of chromium supplements for improving glycemic control as measured by decreases in fasting plasma glucose (FPG) or hemoglobin A1c (HbA1c). Using systematic search criteria, 20 randomized controlled trials of chromium supplementation in T2DM patients were identified. Clinically meaningful treatment goals were defined as an FPG of 7.2 mmol/dL, a decline in HbA1c to 7%, or a decrease of 0.5% in HbA1c. In only a few randomized controlled trials did FPG (5 of 20), HbA1c (3 of 14), or both (1 of 14) reach the treatment goals with chromium supplementation. HbA1c declined by 0.5% in 5 of 14 studies. On the basis of the low strength of existing evidence, chromium supplements have limited effectiveness, and there is little rationale to recommend their use for glycemic control in patients with existing T2DM. Future meta-analyses should include only high-quality studies with similar forms of chromium and comparable inclusion/exclusion criteria to provide scientifically sound recommendations for clinicians.

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“…[65] Some researchers have stated that Cr is an essential element for the human body and necessary for insulin functioning and glucose metabolism. [43,66] Palizban et al in Isfahan showed, low Cr blood concentration was associated with diabetes and metabolic syndrome; and therefore suggested taking this element as a supplement. [25] A study by Rafiei et al in Isfahan showed that Cr deficiency was common in prediabetes patients and suggested that patients with diabetes and prediabetes should be screened for Cr; and Cr deficiency should be eliminated in these patients.…”

Section: Environmental Exposure To Crmentioning

confidence: 99%

Environmental and occupational exposure to chromium in Iran: A systematic review

Tavakkoli

Nasab

Khanjani

2017

JER

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Background: Chromium (Cr) is a heavy metal and trace mineral found in various forms. Cr III is an essential nutrient, that is normally found in human blood and urine; in contrast, Cr VI is listed in group I carcinogens and is hazardous for human health. Several studies have been done about measuring human Chromium levels in Iran and this review attempted to summarize these studies. Methods: Electronic resources including SID, Magiran, PubMed, Web of Knowledge, and Google Scholar were searched; with phrases including "Exposure to Chromium, Chromium exposure, Chromium measuring, Occupational exposure to Chromium, Environmental exposure to Chromium, Chromium" and their Persian translations until December 2, 2016. Results: From the 1,309 retrieved articles, 32 articles were selected. In welding, electroplating and cement companies, chromium concentrations in workers who dealt directly with Cr were higher than others employees. In the general population, people who lived near a factory or an industrial center, or people who had taken dental treatments especially with orthodontic appliances, had higher Cr levels. Cr deficiency was also investigated in several studies, for its possible relation to diabetes type 2. Conclusion: Cr VI exposure should be under surveillance in Iranian industrial workers; and residential areas should be kept in a safe distance from Cr producing industries. Cr III deficiency might be related to diabetes type 2.

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Role of chromium supplementation in Indians with type 2 diabetes mellitus

Cited by 129 publications

References 68 publications

Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic Control

Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic Control

Chromium supplements for glycemic control in type 2 diabetes: limited evidence of effectiveness

Environmental and occupational exposure to chromium in Iran: A systematic review

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