Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic Control

Rajendran, Kannan; Manikandan, Senthil; Nair, Lal Devayani Vasudevan; Karuthodiyil, Rajendran; Vijayarajan, Nikhilan; Gnanasekar, Rajiv; Kapil, Vivian; Mohamed, Azeem S

doi:10.7860/jcdr/2015/16062.6753

Cited by 23 publications

(21 citation statements)

References 19 publications

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“…The current study shows a significant elevation of the mean of the serum levels of triglycerides among the Open Journal of Blood Diseases diabetic patients when compared to the control group, this agrees with a study done by Sarkar Chandra Bidan [11], who found the mean of the serum levels of triglycerides of the test group was significantly raised when compared with the control group. In our study the diabetic patients have a significant reduction in the means of the serum levels of chromium when compared to the control group, this result agrees with that reported by Rajendran Kannan et al [12], who found the mean of the serum levels of chromium was significantly lower in diabetic patients than in the control subjects, this is in coordination with the findings of Morris et al [13], Ekmekcioglu et al [14], and Kazi et al [15] that indicated lower blood levels of chromium in diabetics than in nondiabetics. The explanation of this result can be obtained from other studies which showed that the rates of absorption and excretion of chromium in diabetics are more than in nondiabetics (Anderson et al also SHRABANI M et al [16] [17]; Hamad et al [18]).…”

Section: Discussionsupporting

confidence: 93%

A Study of Correlation of Serum Chromium Level with Glycosylated Haemoglobin (HbA1c), Total Cholesterol and Triglycerides, among Type 2 Diabetes Patients

Mohamed¹,

Sadik²,

Eltom³

et al. 2019

OJBD

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Background: Diabetes mellitus is a common disease and it is a major cause of morbidity; several studies indicate that diabetes is a likely under reported cause of death. Chromium's is important trace element to control diabetes mellitus and metabolism of carbohydrate, lipid and protein. Objective: The purpose of this study was to understand the relationship between serum chromium, with HbA1c, Total cholesterol and Triglycerides among type 2 diabetes patients among diabetic patients. Methodology: This is cross-sectional study done in Jabber Abu Ezz Centre for treatment and care of diabetics in Khartoum-Sudan. Four hundred subjects were enrolled in this study; one hundred subjects were normal healthy as control group, and three hundred subjects diabetic patient type 2 as test group; demographic and biochemical data were collected; serum chromium, Glycosylated Haemoglobin (HbA1c), Total cholesterol Triglycerides, were determined by using NYCOCARD READER II, spectrophotometer (Biosystem 310) and spectrophotometer 210-VGP. Result: In this study there is significant parameters level means of FBS HbA1c, Total Cholesterol, Triglycerides and Chromium of the test groups when compared with healthy control groups subjects (P = 0.001, 0.018, 0.01, 0.011, 0.004), respectively. Significant negative correlation is between FBS, HbA1c, Total Cholesterol, Triglycerides and Chromium (r = −0.555, P value = 0.003), (r = −0.668, P value = 0.002), (r = −0.335, P value = 0.004) and (r = −0.774, P value = 0.002) respectively. Conclusion: There was

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Section: Discussionsupporting

confidence: 93%

A Study of Correlation of Serum Chromium Level with Glycosylated Haemoglobin (HbA1c), Total Cholesterol and Triglycerides, among Type 2 Diabetes Patients

Mohamed¹,

Sadik²,

Eltom³

et al. 2019

OJBD

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“…Chromium can reduce fasting blood glucose levels in diabetic patients and diabetic rodent models [11], and enhance insulin action, including activation of insulin receptor sites [12]. Diabetic animals [13] and patients [14,15] have lower chromium levels than that of controls. Chromium deficiency is common among our population.…”

Section: Introductionmentioning

confidence: 99%

Maternal Chromium Restriction Leads to Glucose Metabolism Imbalance in Mice Offspring through Insulin Signaling and Wnt Signaling Pathways

Zhang

Sun

Xiao

et al. 2016

IJMS

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An adverse intrauterine environment, induced by a chromium-restricted diet, is a potential cause of metabolic disease in adult life. Up to now, the relative mechanism has not been clear. C57BL female mice were time-mated and fed either a control diet (CD), or a chromium-restricted diet (CR) throughout pregnancy and the lactation period. After weaning, some offspring continued the diet diagram (CD-CD or CR-CR), while other offspring were transferred to another diet diagram (CD-CR or CR-CD). At 32 weeks of age, glucose metabolism parameters were measured, and the liver from CR-CD group and CD-CD group was analyzed using a gene array. Quantitative real-time polymerase chain reaction (qPCR) and Western blot were used to verify the result of the gene array. A maternal chromium-restricted diet resulted in obesity, hyperglycemia, hyperinsulinemia, increased area under the curve (AUC) of glucose in oral glucose tolerance testing and homeostasis model assessment of insulin resistance (HOMA-IR). There were 463 genes that differed significantly (>1.5-fold change, p < 0.05) between CR-CD offspring (264 up-regulated genes, 199 down-regulated genes) and control offspring. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and STRING (Search Tool for the Retrieval of Interacting Genes/Proteins) analysis revealed that the insulin signaling pathway and Wnt signaling pathway were in the center of the gene network. Our study provides the first evidence that maternal chromium deficiency influences glucose metabolism in pups through the regulation of insulin signaling and Wnt signaling pathways.

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“…Diabetic patients have low circulating and tissue Cr3+ levels compared to non-diabetic individuals29. There is increasing evidence that inadequate Cr3+ intake may elevate blood glucose and lipid levels30.…”

mentioning

confidence: 99%

Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE−/− mice

Ganguly

Sahu

Ohanyan

et al. 2017

Sci Rep

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Increasing evidence suggests thrombospondin-1 (TSP-1), a potent proatherogenic matricellular protein, as a putative link between hyperglycemia and atherosclerotic complications in diabetes. We previously reported that the micronutrient chromium picolinate (CrP), with long-standing cardiovascular benefits, inhibits TSP-1 expression in glucose-stimulated human aortic smooth muscle cells in vitro. Here, we investigated the atheroprotective action of orally administered CrP in type 1 diabetic apolipoprotein E-deficient (ApoE−/−) mice and elucidated the role of TSP-1 in this process. CrP decreased lipid burden and neointimal thickness in aortic root lesions of hyperglycemic ApoE−/− mice; also, smooth muscle cell (SMC), macrophage and leukocyte abundance was prevented coupled with reduced cell proliferation. Attenuated lesion progression was accompanied with inhibition of hyperglycemia-induced TSP-1 expression and reduced protein O-glycosylation following CrP treatment; also, PCNA and vimentin (SMC synthetic marker) expression were reduced while SM-MHC (SMC contractile marker) levels were increased. To confirm a direct role of TSP-1 in diabetic atherosclerosis, hyperglycemic TSP-1−/−/ApoE−/− double knockout mice were compared with age-matched hyperglycemic ApoE−/− littermates. Lack of TSP-1 prevented lesion formation in hyperglycemic ApoE−/− mice, mimicking the atheroprotective phenotype of CrP-treated mice. These results suggest that therapeutic TSP-1 inhibition may have important atheroprotective potential in diabetic vascular disease.

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Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic Control

Cited by 23 publications

References 19 publications

A Study of Correlation of Serum Chromium Level with Glycosylated Haemoglobin (HbA1c), Total Cholesterol and Triglycerides, among Type 2 Diabetes Patients

A Study of Correlation of Serum Chromium Level with Glycosylated Haemoglobin (HbA1c), Total Cholesterol and Triglycerides, among Type 2 Diabetes Patients

Maternal Chromium Restriction Leads to Glucose Metabolism Imbalance in Mice Offspring through Insulin Signaling and Wnt Signaling Pathways

Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE−/− mice

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