Role of Chlamydia trachomatis in non-acute prostatitis.

Chlamydia trachomatisin ‘Abacterial’ P Prostatitis: Microbiological, Cytological and Serological Studies

“…trachomatis can be isolated from the urethra of healthy men [11], Consequently, mere isolation of C. tra chomatis from urethral samples [7], urine after prostatic massage [2], EPS [2] and semen [2] alone appears insuffi cient proof that this microorganism is involved in exist ing disease.…”

“…Serological investigations [1,7] and the determination of leuco cytes in EPS [6] were suggested for this purpose. In our study, a response of humoral antibodies against C. tra chomatis was significantly more often detected in pa tients suffering from 'abacterial' prostatitis with posi tive culture of C. trachomatis from EPS and high leu cocyte numbers in VB3, than in patients with prostatodynia with normal numbers of granulocytes in VB3 and chlamydia-positive culture from EPS.…”

Chlamydial Infection in Urologic Diseases

“…Although Mardh and Colleen (Mardh et al, 1972) suggested that C. trachomatis may be implicated in as many as one third of men with CP, their follow-up studies employing culturing and serologic tests could not confirm C. trachomatis as an etiologic agent in idiopathic prostatitis (Mardh & Colleen, 1975;Mardh et al, 1978). Shortliffe and Wehner (Shortliffe & Wehner, 1986) came to a similar conclusion when they evaluated antichlamydial antibody titers in prostatic fluid.…”

Inhibition of Chlamydia trachomatis growth in McCoy, HeLa, and human prostate cells by zinc

“…The amount of zinc found in the processed human prostate epithelial cells discussed here was too low to inhibit chlamydial growth. It is not known whether the prostate can be infected in vivo, although serological studies show such infections to be uncommon (24). Nevertheless, the presence of increased concentrations of free zinc in prostatic fluid could decrease the recovery of chlamydia from this site.…”

“…Although C. trachomatis has not been definitively shown to cause acute or chronic prostatitis, some investigators have implicated it with their serological results (24).…”