Role of Cerebral Dopamine and Noradrenaline in the Morphine-induced Locomotor Sensitisation in Mice

Chronic and intermittent morphine treatment differently regulates opioid and dopamine systems: a role in locomotor sensitization

“…Similar data were obtained in rats where a chronic morphine regimen induced a tolerance to locomotor effects of morphine 18 h after withdrawal (Timar et al 2005). In NMRI mice treated with a chronic morphine treatment for 5 days, tolerance to locomotor effect of morphine was observed after 1 day withdrawal while a sensitization was observed after 5 days (Airio and Ahtee 1997). The lack of locomotor sensitization the first day of withdrawal following chronic morphine treatment could be due to induction of morphine dependency.…”

The developmental neurobehavioral effects of fenugreek seeds on prenatally exposed mice

“…The observed decrease in locomotor activity suggests a disruption of activity in mesolimbic dopaminergic systems, which are strongly related to the neuromotor system and to locomotor activity (Fink and Smith, 1980;Jacobs and Fornal, 1995;Airio and Ahtee, 1997;Giménez-Llort et al, 1997).…”

Chronic nicotine modifies the effects of morphine on extracellular striatal dopamine and ventral tegmental GABA

“…DA release is involved in the increase in locomotor activity seen after administration of nicotine (Clarke et al. 1988; Benwell and Balfour 1992) and morphine (Kuschinsky and Hornykiewicz 1974; Saito 1990; Airio and Ahtee 1997). To further investigate the role of the DAergic system in the interaction of nicotine and morphine, we performed in vivo DA microdialysis in the caudate putamen (CPu) and nucleus accumbens (NAc) of mice chronically treated with nicotine.…”