Role of cerebral arterial blood in the regulation of brain temperature in the monkey

Hayward, James N.; Baker, M. A.

doi:10.1152/ajplegacy.1968.215.2.389

Cited by 228 publications

(165 citation statements)

References 11 publications

Supporting

Mentioning

143

Contrasting

Unclassified

Order By: Relevance

“…Proteins and amino acids may have a pyrogen-like influence and reset the set point in the awake state (16,17), possibly via a second messenger. Body oxidative metabolism keeps the body core temperature constant and prevents hypothermia in the awake state (18). However, anesthesia may suppress this thermic control.…”

Section: Discussionmentioning

confidence: 99%

Bolus Oral or Continuous Intestinal Amino Acids Reduce Hypothermia during Anesthesia in Rats

Imoto¹,

Yokoyama²,

Suwa³

et al. 2010

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

SummaryWe hypothesized that, with oral or intestinal administration of amino acids (AA), we may reduce hypothermia during general anesthesia as effectively as with intravenous AA. We, therefore, examined the effect of bolus oral and continuous intestinal AA in preventing hypothermia in rats. Male Wistar rats were anesthetized with sevoflurane for induction and with propofol for maintenance. In the first experiment, 30 min before anesthesia, rats received one bolus 42 mL/kg of AA solution

show abstract

Section: Discussionmentioning

confidence: 99%

Bolus Oral or Continuous Intestinal Amino Acids Reduce Hypothermia during Anesthesia in Rats

Imoto¹,

Yokoyama²,

Suwa³

et al. 2010

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

show abstract

“…35,36 This may be explained by the high metabolic activity of cerebral tissue with considerable production of heat. 37 Another possibility is that in the early stages of infarct formation, a decrease in cerebral blood flow may result in a decreased capacity for the blood to carry off heat generated by local cerebral metabolism. In animal studies, it was reported that toxicity from moderate hypothermia increases as the temperature is further decreased and as the duration of hypothermia is increased.…”

Section: Discussionmentioning

confidence: 99%

Moderate Hypothermia in the Treatment of Patients With Severe Middle Cerebral Artery Infarction

Schwab

Schwarz

Spranger

et al. 1998

Stroke

598

351

View full text Add to dashboard Cite

Background and Purpose-Animal research and clinical studies in head trauma patients suggest that moderate hypothermia may improve outcome by attenuating the deleterious metabolic processes in neuronal injury. Clinical studies on moderate hypothermia in the treatment of acute ischemic stroke patients are still lacking. Methods-Moderate hypothermia was induced in 25 patients with severe ischemic stroke in the middle cerebral artery (MCA) territory for therapy of postischemic brain edema. Hypothermia was induced within 14Ϯ7 hours after stroke onset and achieved by external cooling with cooling blankets, cold infusions, and cold washing. Patients were kept at 33°C body-core temperature for 48 to 72 hours, and intracranial pressure (ICP), cerebral perfusion pressure, and brain temperature were monitored continuously. Outcome at 4 weeks and 3 months after the stroke was analyzed with the Scandinavian Stroke Scale (SSS) and Barthel index. The side effects of induced moderate hypothermia were analyzed. Results-Fourteen patients survived the hemispheric stroke (56%). Neurological outcome according to the SSS score was 29 (range, 25 to 37) 4 weeks after stroke and 38 (range 28 to 48) 3 months after stroke. During hypothermia, elevated ICP values could be significantly reduced. Herniation caused by a secondary rise in ICP after rewarming was the cause of death in all remaining patients. The most frequent complication of moderate hypothermia was pneumonia in 10 of the 25 patients (40%). Other severe side effects of hypothermia could not be detected. Conclusions-Moderate hypothermia in the treatment of severe cerebral ischemia is not associated with severe side effects.Moderate hypothermia can help to control critically elevated ICP values in severe space-occupying edema after MCA stroke and may improve clinical outcome in these patients. (Stroke. 1998;29:2461-2466.)

show abstract

“…Although administration of low doses of IL-1 and IL-1RA can influence outcome from experimental cerebral ischemia independently of rectal temperature (10,11), core body temperature may not be representative of temperature in critical ischemic areas of the brain. Brain temperature in health correlates well with body temperature (12,13) but there is good evidence that brain temperature dissociates from body temperature during ischemia. Ischemic brain temperature falls by 1-2°C relative to rectal temperature in rodent models of focal cerebral ischemia with little change in the temperature of the nonischemic hemisphere (14,15).…”

mentioning

confidence: 99%

Interleukin‐1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat

Parry‐Jones

Liimatainen

Kauppinen

et al. 2008

Magnetic Resonance in Med

View full text Add to dashboard Cite

The proinflammatory cytokine interleukin-1 (IL-1) is a key mediator of inflammation in cerebral ischemia, but its precise mechanisms of action remain elusive. Temperature is critical to outcome in brain injury and given the importance of IL-1 in pyrogenesis this has clear mechanistic implications. IL-1 exacerbates ischemia independently of core (rectal) temperature. However, it is temperature in the ischemic brain that influences outcome and rectal temperature is likely to be a poor surrogate marker. This study tested the hypothesis that IL-1 exacerbates cerebral ischemia by increasing ischemic brain temperature. Wistar rats undergoing transient middle cerebral artery occlusion received either 4 g/kg IL-1 (n ‫؍‬ 9) or vehicle (n ‫؍‬ 10) intraperitoneally. NMR-generated maps of brain temperature, tissue perfusion, and the trace of the diffusion tensor were collected during occlusion, early reperfusion, and at 24 hr. IL-1 significantly increased ischemic damage at 24 hr by 35% but rectal temperature did not vary significantly between groups. However, ischemic brain was 1.7°C cooler on reperfusion in IL-1-treated animals (vs. vehicle) and a corresponding reduction in cerebral blood flow was identified in the ischemic striatum. Contrary to the stated hypothesis, IL-1 reduced ischemic brain temperature during reperfusion and this may be due to a reduction in tissue perfusion.

show abstract

Role of cerebral arterial blood in the regulation of brain temperature in the monkey

Cited by 228 publications

References 11 publications

Bolus Oral or Continuous Intestinal Amino Acids Reduce Hypothermia during Anesthesia in Rats

Bolus Oral or Continuous Intestinal Amino Acids Reduce Hypothermia during Anesthesia in Rats

Moderate Hypothermia in the Treatment of Patients With Severe Middle Cerebral Artery Infarction

Interleukin‐1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat

Contact Info

Product

Resources

About