Role of Central 5-HT2 Receptors in Fluoxetine-Induced Decreases in T Lymphocyte Activity

Pellegrino, Trisha C.; Bayer, Barbara

doi:10.1006/brbi.2001.0625

Cited by 52 publications

(41 citation statements)

References 67 publications

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“…Re-distribution of the cells from thymus, spleen and lymphatic nodes may be due to the shift in the neurochemical balance in the cerebral system towards the activation of the serotonergic system (it is known that such activation is accompanied by the decreasing activity of the T-lymphocytes [79,80]). The same time the increasing number of the T-lymphocytes in the spleen and lymphatic nodes (CD4+ and CD25+ in the spleen and CD8+ in the lymphatic nodes correspondingly) is regarded to be an indicator of activation of the general serotonin-induced immune reactions resulting from the local skin damage happening during laboratory animal confrontations [81].…”

Section: Organ-level Compensation Of the Behavioral Depressionmentioning

confidence: 99%

Psycho-immune Partnership in the Dynamic Responses of Living Systems

Koptyug²,

Petrov³

et al. 2014

LSMR

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Abstract-Present paper outlines certain possibilities for a new approach to the generalized modeling of the dynamics of living organism reaction to the changes in its environment. It is shown that there exists common functional "alignment" of the immune and psychic responses in the living organism reaction to the changes in the environment. This is manifested in the experimentally recorded matching of the response scenarios and activities in the immune and psychic domains. Thus, one may conclude that there exist two functionally matched systems (psychic and immune) tracking the external influences and responding to them. On the other hand it is feasible that one is actually dealing with a complex inseparable psycho-immune system and experimentally monitors different aspects of its activity describing these from two different points of view. Given analysis of available experimental data seems to support both of the above alternatives without giving undoubted preferences to any of them. However treating the situation form the formal logic point of view certain preferences can be given to the concept of an inseparable psycho-immune system modeled in two different ways. This approach can also resolve certain collisions happening with the attempts to describe direct interrelations between psychic and immune domains, and can lead the way to higher-level functionality models of the dynamic responses of the living organisms.

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Section: Organ-level Compensation Of the Behavioral Depressionmentioning

confidence: 99%

Psycho-immune Partnership in the Dynamic Responses of Living Systems

Koptyug²,

Petrov³

et al. 2014

LSMR

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“…Pellegrino & Bayer (2002) observed that the in vitro proliferation of lymphocytes from rats that had received fluoxetine via i.p. (5 mg/kg) was lower than their respective controls, suggesting that the antidepressant has an immunosuppressive role for lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Humoral Immune Response of Wistar Rats Submitted to Forced Swimming and Treated with Fluoxetine

Fernandes¹,

Venâncio²,

Estanislau³

2012

Effects of Antidepressants

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“…once at a dose of 1.0 mg/kg 30 min prior to immunization. The doses, timing and administration routes of drugs were based on the data of other authors [27] and on those used in our previous studies [29]. Control groups of rats received an equivalent volume of corresponding vehicle for the same period of time.…”

Section: -[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridyl)mentioning

confidence: 99%