Effects of Activation and Blockade of Serotonin 5-HT1A Receptors on the Immune Response in Rats Selected for Different Levels of Aggressiveness

Альперина, Е. Л.; Жукова, Е. Н.; Идова, Г. В.; Kozhemyakina, R. V.; Cheido, M. A.

doi:10.4236/pp.2015.69047

Cited by 5 publications

(3 citation statements)

References 44 publications

(51 reference statements)

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“…Compared to nonaggressive line, rats selected for the enhanced aggressiveness toward humans showed significantly higher IgM-immune response to SRBC (Figure 1), that is characteristic of this genetic line [18] [28] [29]. Activation of 5-HT 2A receptors with DOI (1.0 mg/kg) in nonaggressive rats did not affect the numbers of IgM-AFC (p > 0.05) compared to animals of this line not treated with the drug (vehicle-injected group).…”

Section: Effects Of Activation Of 5-ht2a Receptors On the Immune Respmentioning

confidence: 99%

“…Moreover, a number of atypical antipsychotic drugs and antidepressants, targeting 5-HT 2A receptors, have been successfully used in patients with various neuropsychiatric disorders [4], which are known to be associated with abnormal aggression and altered immune function [7]- [9]. A number of studies have also demonstrated that 5-HT receptor subtypes are involved in the 5-HTergic mechanisms of immunomodulation [10]- [18].…”

Section: Introductionmentioning

confidence: 99%

“…An important role of pre-and postsynaptic 5-HT 1A receptors in the immune response control has been shown not only in normal, but also in mice and rats displaying either depressive-like behavior or increased aggressiveness [14] [16] [18]- [21]. It has also been reported that activation of 5-HT 2A receptors, localized only postsynaptically, with their preferential agonist DOI resulted in a decrease of the rosette-forming cell numbers and cytotoxic/suppressor CD8 + T lymphocytes in the spleen of mice [15], as well as in the proliferative activity of T lymphocytes in rats [13].…”

Section: Introductionmentioning

confidence: 99%

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Role of 5-HT2A Receptors in Immunomodulation in Animal Models of Aggressive Behavior

Идова¹,

Альперина²,

Жукова³

et al. 2016

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Serotonin 5-HT2A receptors are playing an important role in the pathophysiology of aggressive behaviors and in the control of immune function. In the present study, we analyzed the effects of activation and blockade of 5-HT2A receptors with selective ligands on the immune response formation in animals with aggressive behaviors induced by genetic factors (rats selected for the increased aggressiveness toward human) or by chronic social stress (mice of the CBA/Lac strain engaged in 10 days of social confrontations). Activation of 5-HT2A receptors with DOI at 1.0 mg/kg reduced the immune response level both in aggressive rats and mice compared to the corresponding vehicle-treated groups, while DOI administration did not alter the immune reaction in nonaggressive animals. The blockade of 5-HT2A receptors with ketanserin at 1.0 mg/kg resulted in immunostimulation both in mice of the CBA strain not subjected to social stress (the controls) and in nonaggressive rats selected for elimination of aggressiveness. On the other hand, its administration to CBA mice demonstrating offensive aggression enhanced the immune reaction, while the same dose of ketanserin did not modify the immune response level in rats with genetic predisposition to the increased defensive aggression. Thus, our data suggest that the role of 5-HT2A receptors in immunomodulation depends on the specific type of aggression that may be taking into account in the treatment of some neuropsychiatric disorders with the antipsychotic drugs and antidepressants targeting 5-HT2A receptors.

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Section: Effects Of Activation Of 5-ht2a Receptors On the Immune Respmentioning

confidence: 99%