Role of CBX4 in the Colorectal Carcinoma Metastasis—Response

Wang, Xin; Kang, Tiebang

doi:10.1158/0008-5472.can-17-0594

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…It is known that CBX4 is an important component of polycomb gene protein family which is located on human chromosome 17. As the only active enzyme protein in this family, the role of CBX4 in tumor is related to its multiple unique domains, and it participates in control of cell proliferation, differentiation, transformation and other biological functions in vivo [9,10]. Some scholars have found that CBX4 is upregulated in liver cancer patients, and the survival rate of these patients is markedly low, when compared to low-expression patients.…”

Section: Discussionmentioning

confidence: 99%

Effect of CBX4/miR-137/Notch1 signaling axis on the proliferation and migration of breast cancer cells

Ma¹,

Zheng²,

Zhang³

et al. 2022

Trop. J. Pharm Res

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Purpose: To study the effect of CBX4/miR-137/Notch1 signaling axis on the migration and proliferative capacity of breast cancer. Methods: Breast cancer MCF7 cell lines were cultured in vitro and transfected with CBX4- overexpressed plasmid and interfering plasmid, which served as CBX4 over-expressing group and CBX4 interfering group, respectively. A control group (blank plasmid transfection) was set up. The MCF7 cells were transfected with miR-137 over-expressed plasmid, miR-137 interfering plasmid and Notch1 interfering plasmid, which served as miR-137 over-expressing, miR-137 interference and Notch1 interference groups, respectively. Cell proliferation and migration capacity were determined with methylthiazolyldiphenyl-tetrazolium (MTT) method and Transwell migration assay, respectively, while reverse transcription-polymerase chain reaction (RT-PCR) and immunoblotting were used to assay related gene expressions. Results: Cell migration in CBX4 over-expressing group was significantly raised (p < 0.05). The expression of miR-137 in CBX4 over-expressing group was markedly decreased (p < 0.05). Compared with the control group, mRNA and protein expressions of Notch1 (NICD), Hey2 and Jag1 in miR-137 over-expressing cells were increased in the miR-137 interfering group (p < 0.05). Conclusion: CBX4 level is increased in mammary cancer cells. Moreover, CBX4 enhances cell proliferation and migration through induction of Notch1 signaling route by inhibiting miR-137 expression. These findings provide a new strategy for clinical therapy of mammary cancer.

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Section: Discussionmentioning

confidence: 99%

Effect of CBX4/miR-137/Notch1 signaling axis on the proliferation and migration of breast cancer cells

Ma¹,

Zheng²,

Zhang³

et al. 2022

Trop. J. Pharm Res

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show abstract

“…The Polycomb orthologs CBX2, CBX4, CBX6, CBX7, and CBX8 have a C-terminal polycomb repressor box that serves as a canonical component in Polycomb Repressive Complex 1 3 . Dysregulation of CBX family proteins is associated with tumorigenesis of many cancers, such as breast cancer 4 , pancreatic cancer 5 , thyroid cancer 6 , colorectal cancer 7 , lung cancer 8 , and ovarian cancer 9 .…”

Section: Introductionmentioning

confidence: 99%

Bioinformatic analysis of the expression and prognostic value of chromobox family proteins in human breast cancer

Gou

et al. 2020

Sci Rep

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Chromobox (CBX) family proteins control chromatin structure and gene expression. However, the functions of CBXs in cancer progression, especially breast cancer, are inadequately studied. We assessed the significance of eight CBX proteins in breast cancer. We performed immunohistochemistry and bioinformatic analysis of data from Oncomine, GEPIA Dataset, bcGenExMiner, Kaplan–Meier Plotter, and cBioPortal. We compared mRNA and protein expression levels of eight CBX proteins between breast tumor and normal tissue. The expression difference of CBX7 was the greatest, and CBX7 was downregulated in breast cancer tissues compared with normal breast tissues. The expression of CBX2 was strongly associated with tumor stage. We further analyzed the association between the eight CBX proteins and the following clinicopathological features: menopause age, estrogen receptor (ER), progesterone receptor (PR) and HER-2 receptor status, nodal status, P53 status, triple-negative status, and the Scarff–Bloom–Richardson grade (SBR) and Nottingham prognostic index (NPI). Survival analysis in the Kaplan–Meier Plotter database showed that the eight CBX proteins were significantly associated with prognosis. Moreover, CBX genes in breast cancer patients had a high net alteration frequency of 57%. There were significant co-expression correlations between the following CBX protein pairs: CBX4 positively with CBX8, CBX6 positively with CBX7, and CBX2 negatively with CBX7. We also analyzed the Gene Ontology enrichment of the CBX proteins, including biological processes, cellular components, and molecular functions. CBX 1/2/3/5/8 may be oncogenes for breast cancer, whereas CBX 6 and 7 may be tumor suppressors for breast cancer. All eight CBX proteins may be predictive for prognosis. Clinical trials are needed to confirm the significance of the eight CBX proteins in breast cancer.

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Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway

et al. 2021

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Role of CBX4 in the Colorectal Carcinoma Metastasis—Response

Cited by 3 publications

References 4 publications

Effect of CBX4/miR-137/Notch1 signaling axis on the proliferation and migration of breast cancer cells

Effect of CBX4/miR-137/Notch1 signaling axis on the proliferation and migration of breast cancer cells

Bioinformatic analysis of the expression and prognostic value of chromobox family proteins in human breast cancer

Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway

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