Role of Caspase-3, IL-1β and oxidative stress in Iraqi women with breast cancer

Abstract

Breast Cancer is caused by malignant tissue cells and has become one of the world’s biggest medical problems. The goal of this research was to determine the serum concentration of markers of oxidative stress that play an important role in the multiple factors involved in breast cancer development, growth, and invasion. Serum of 90 women patients (45 breast cancer and 45 benign breast tumors) and 42 healthy individuals as control group were used in this study. Serum level of MDA, PC, 8-OHdG, IL-1β and Caspase-3 were measured by ELISA. Highly significantly increased levels (p<0.01) of MDA, PC, 8-OHdG, IL-1β and Caspase-3 were found in breast cancer and benign breast tumor when compared to healthy controls. The MDA and Caspase-3 level are considered strong parameters to diagnose and detection for breast cancer using the ROC curve. High lipid peroxidation is a significant risk factor for breast cancer and the activation of apoptosis and pro-inflammatory activity may be due to elevated levels of IL-1β & Caspase-3 in breast cancer cells. Nonetheless, lipid peroxidation and Caspase-3 are major factors in breast cancer growth and progression.

Revision of some Biomarkers with Cytokines in Breast Cancer

“…All of the above research showed results which agree with this revision. AL-Musawi et al noticed that significantly raising of serum MDA, PC, 8-OHdG, IL-1β and Caspase-3 concentrations in breast sarcoma and nonthreatening breast tumor when compared to healthy subjects 30 . Verigos et al stated that elevated levels of serum 8-OHdG and 8-NG were observed during the course of irradiation in breast malignancy 14 .…”

Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters

“…AL-Musawi et al . [ 57 ] demonstrated that high lipid peroxidation is an important risk factor for BC. Another study conducted in Finland by Karihtala et al .…”

“…These results mirror those of Sharma et al [56], who found that high levels of 4-HNE were observed in BC. AL-Musawi et al [57] demonstrated that high lipid peroxidation is an important risk factor for BC. Another study conducted in Finland by Karihtala et al [58] showed that 4-HNE is a marker of lipid peroxidation, which increases during breast carcinogenesis, suggesting a role of oxidative stress in the pathogenesis of BC.…”