Role of carotenoids in adipose tissue through the AMPK-mediated pathway

Ferreira, Yasmin Yasmin Alaby Martins; Jamar, Giovana; Estadella, Débora; Pisani, Luciana Pellegrini

doi:10.1039/d2fo03781e

Cited by 7 publications

(5 citation statements)

References 83 publications

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“…Cyclooxygenase (COX) is a key enzyme that promotes cancer progression through arachidonic acid metabolism. 26 The anti-inflammatory mechanism of CS and its components involves the activation of the mitogen-activated protein kinase (MAPK) signal pathway, inflammatory related enzymes, and the regulation of nuclear factor kappa B (NF-κB) pathways. 21 Among them, MAPK signaling pathway is closely related to the occurrence of various cancers, and drugs targeting the key targets of this pathway for cancer therapy have been marketed in recent years.…”

Section: Functional Properties Of Csmentioning

confidence: 99%

A review of the functional activities of chia seed and the mechanisms of action related to molecular targets

Chen,

Wu,

Zhu

et al. 2024

Food Funct.

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Section: Functional Properties Of Csmentioning

confidence: 99%

A review of the functional activities of chia seed and the mechanisms of action related to molecular targets

Chen,

Wu,

Zhu

et al. 2024

Food Funct.

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“…Additionally, carotenoids can also be metabolized in the intestine and other tissues into vitamin A-like bioactive compounds, which provide immunomodulation and enhance the immune response [ 149 ]. Carotenoid supplementation activates the AMPK signaling pathway, which in turn activates upstream kinases, upregulates transcription factors, induces the discoloration of white adipose tissue, and blocks adipogenesis [ 150 , 151 ]. Lycopene is a carotenoid [ 152 ] with antioxidant, anti-inflammatory, apoptotic and cellular communication-modulating effects [ 153 ].…”

Section: Natural Compounds That Regulate Glucolipid Metabolismmentioning

confidence: 99%

Mechanisms of regulation of glycolipid metabolism by natural compounds in plants: effects on short-chain fatty acids

Li,

Zhao,

Tian

et al. 2024

Nutr Metab (Lond)

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Background Natural compounds can positively impact health, and various studies suggest that they regulate glucose‒lipid metabolism by influencing short-chain fatty acids (SCFAs). This metabolism is key to maintaining energy balance and normal physiological functions in the body. This review explores how SCFAs regulate glucose and lipid metabolism and the natural compounds that can modulate these processes through SCFAs. This provides a healthier approach to treating glucose and lipid metabolism disorders in the future. Methods This article reviews relevant literature on SCFAs and glycolipid metabolism from PubMed and the Web of Science Core Collection (WoSCC). It also highlights a range of natural compounds, including polysaccharides, anthocyanins, quercetins, resveratrols, carotenoids, and betaines, that can regulate glycolipid metabolism through modulation of the SCFA pathway. Results Natural compounds enrich SCFA-producing bacteria, inhibit harmful bacteria, and regulate operational taxonomic unit (OTU) abundance and the intestinal transport rate in the gut microbiota to affect SCFA content in the intestine. However, most studies have been conducted in animals, lack clinical trials, and involve fewer natural compounds that target SCFAs. More research is needed to support the conclusions and to develop healthier interventions. Conclusions SCFAs are crucial for human health and are produced mainly by the gut microbiota via dietary fiber fermentation. Eating foods rich in natural compounds, including fruits, vegetables, tea, and coarse fiber foods, can hinder harmful intestinal bacterial growth and promote beneficial bacterial proliferation, thus increasing SCFA levels and regulating glucose and lipid metabolism. By investigating how these compounds impact glycolipid metabolism via the SCFA pathway, novel insights and directions for treating glucolipid metabolism disorders can be provided.

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“…Several studies have been conducted to investigate the potential use of carotenoids in managing obesity. However, many of these studies used a combination of carotenoids and vitamins in natural sources, such as fruit juices or plant extracts, making it difficult to determine the specific effects of carotenoids alone [ 164 , 165 , 166 ]. According to our knowledge, only two clinical trials have been conducted that were randomized, double-blind, placebo-controlled, and investigated the effect of pure carotenoid or xanthophyll supplementation.…”

Section: Anti-obesity Effects Of Carotenoids and Their Possible Mecha...mentioning

confidence: 99%

A Review of the Anti-Obesity Effects of Wild Edible Plants in the Mediterranean Diet and Their Active Compounds: From Traditional Uses to Action Mechanisms and Therapeutic Targets

Saad

2023

IJMS

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Obesity is a long-term condition resulting from a continuous imbalance between the amount of energy consumed and expended. It is associated with premature mortality and contributes to a large portion of the global chronic disease burden, including diabesity, cardiovascular disease, hypertension, and some cancers. While lifestyle changes and dietary adjustments are the primary ways to manage obesity, they may not always be sufficient for long-term weight loss. In these cases, medication may be necessary. However, the options for drugs are limited due to their potential side effects. As a result, there is a need to identify safe and effective alternative treatments. Recently, dietary compounds, plants, and bioactive phytochemicals have been considered as promising sources for discovering new pharmacological agents to treat obesity and its related complications. These natural products can function independently or synergistically with other plants to augment their effects at various levels of the body. They can modulate appetite, lipase activity, thermogenesis and fat synthesis and degradation, satiation, adipogenesis, and adipocyte apoptosis. Additionally, targeting adipocyte growth and differentiation with diverse medicinal plants/diet is a significant strategy for devising new anti-obesity drugs that can intervene in preadipocytes, maturing preadipocytes, and mature adipocytes. Clinical trials have shown that the wild edible plants in the Mediterranean diet can reduce the risk of obesity and its related diseases. This review examines the effectiveness of the common components of the Mediterranean diet in managing obesity and its associated health issues. We conducted a comprehensive literature review using PubMed, Science Direct, Google Scholar, and Medline Plus to gather data on the therapeutic effects of the Mediterranean diet and phytochemicals in treating obesity and its associated diseases.

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Role of carotenoids in adipose tissue through the AMPK-mediated pathway

Abstract: Diet is a critical factor in controlling adiposity and white adipose tissue (WAT) physiology. High-fat diet (HFD) alters WAT function and affects the AMP-activated protein kinase (AMPK) - a cellular...

Cited by 7 publications

References 83 publications

A review of the functional activities of chia seed and the mechanisms of action related to molecular targets

A review of the functional activities of chia seed and the mechanisms of action related to molecular targets

Mechanisms of regulation of glycolipid metabolism by natural compounds in plants: effects on short-chain fatty acids

A Review of the Anti-Obesity Effects of Wild Edible Plants in the Mediterranean Diet and Their Active Compounds: From Traditional Uses to Action Mechanisms and Therapeutic Targets

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