Role of carbon nanoparticle suspension in sentinel lymph node biopsy for early‐stage cervical cancer: a prospective study

Ya, X; Qian, Wei; Huiqing, L; Haixiao, W; Weiwei, Zh; Jing, Bo; Lei, Chun; Yang, Jianping; Shuping, Y; Jiaya, M; Dong, Wen; Guo, Ruixia

doi:10.1111/1471-0528.16504

Cited by 18 publications

(22 citation statements)

References 37 publications

(46 reference statements)

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“…The case survey indicates that laparoscopic SLNB mapping with CNSI may be simple and efficient for patients with early-stage cervical cancer. Ya et al further carried out a prospective study of 356 cases to evaluate the clinical diagnostic validity of CNSI in SLNB for assessing the lymphatic spread of early-stage cervical cancer as shown in Figure 4 [ 81 ]. SLNB with CNSI had a sensitivity of 96.65%, a false-negative rate (FNR) of 4.35%, and a negative predictive value (NPV) of 99.29%, which demonstrates that SLNB with CNSI is safe, feasible, and relatively effective for guiding precise surgical treatment of early-stage cervical cancer.…”

Section: Imagingmentioning

confidence: 99%

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The Application of Carbon Nanomaterials in Sensing, Imaging, Drug Delivery and Therapy for Gynecologic Cancers: An Overview

Xiao

Liu

et al. 2022

Molecules

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Gynecologic cancers are one of the main health concerns of women throughout the world, and the early diagnosis and effective therapy of gynecologic cancers will be particularly important for the survival of female patients. As a current hotspot, carbon nanomaterials have attracted tremendous interest in tumor theranostics, and their application in gynecologic cancers has also been developed rapidly with great achievements in recent years. This Overview Article summarizes the latest progress in the application of diverse carbon nanomaterials (e.g., graphenes, carbon nanotubes, mesoporous carbon, carbon dots, etc.) and their derivatives in the sensing, imaging, drug delivery, and therapy of different gynecologic cancers. Important research contributions are highlighted in terms of the relationships among the fabrication strategies, architectural features, and action mechanisms for the diagnosis and therapy of gynecologic cancers. The current challenges and future strategies are discussed from the viewpoint of the real clinical application of carbon-based nanomedicines in gynecologic cancers. It is anticipated that this review will attract more attention toward the development and application of carbon nanomaterials for the theranostics of gynecologic cancers.

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Section: Imagingmentioning

confidence: 99%

“… The technique of CNSI application in SLNB for assessing lymphatic spread of early-stage cervical cancer [ 81 ]. ( A ) Injecting CNSI into the ectocervix at the 3 and 9 o’clock positions superficially by a skin test needle, approximately 5–10 mm from the tumor border and perpendicular to the cervix surface.…”

Section: Figurementioning

confidence: 99%

The Application of Carbon Nanomaterials in Sensing, Imaging, Drug Delivery and Therapy for Gynecologic Cancers: An Overview

Xiao

Liu

et al. 2022

Molecules

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“…The mean size of the CNS is 150 nm, allowing it to easily travel through the lymphatic capillary with an average epithelial gap of 120 to 500 nm but not the blood capillary with an average epithelial gap of 20 to 50 nm. Because of this, CNS has been widely used in diverse fields of surgery [ 12 , 13 ]. During the surgical resection of a tumor, CNS particles migrate quickly in lymphatic vessels and accumulate in lymph nodes, staining them black.…”

Section: Discussionmentioning

confidence: 99%

Chylous ascites with lymphatic leakage localization: technical aspects and clinical applications

Wang

Gao

2022

BMC Surg

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Background Carbon nanoparticle suspension (CNS) was applied to locate the lymphatic leakage in chylous ascites (CA). However, the flow speed and distance of the CNS were particularly decreased in the following two cases (patient 5 and 6). This study aimed to investigate and improve the flow speed and distance of the CNS via a rat model. Methods Seven patients with CA were accepted for surgery in the past two years. Clinical data were recorded. Rats were divided into two groups to confirm the hypothesis regarding whether accepting milk or orally administered food before surgery was the key factor in CA surgery with CNS. The animals were divided into 2 groups: experimental group of 5 rats receiving fat emulsion injection (2 g/kg) 30 min before the operation and control group of 5 rats receiving saline. We analyzed flow speed and distance of the CNS in two groups of rats. The hypothesis established was that CNS movements pattern differ depending on the degree of capillary lymph duct filling. Finally, the late case reconfirmed the hypothesis again. Results In animal experiments, the CNS in the preoperative high-fat feeding group moved faster and over a longer distance than that in the control group (0.51 ± 0.09 cm vs. 0.19 ± 0.10 cm, respectively; p < 0.05). Based on this, the CNS was applied to the seventh patient, who had been given a diet with a slightly higher fat content 3 days before the operation, and marked improvement with a complete cure was recorded. Conclusions The capillary lymph duct was beginning to swell after dietary intake. The dilation of the lymph vessel could make it easier for the CNS to move and reach the leakage.

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“…A study of 356 patients with stage IA2-IIA2 cervical cancer underwent systematic pelvic lymphadenectomy after SLN biopsy with carbon nanoparticles suspension ( 56 ). Results showed that the overall sensitivity was 96.65%, the false-negative rate was 4.35%, and the negative predictive value was 99.29% ( 56 ). The sensitivity and negative predictive value were both 100% and the false-negative rate was reduced to 0% for tumors <2 cm ( 56 ).…”

Section: Introduction To Sentinel Lymph Node Techniquesmentioning

confidence: 99%

Sentinel Lymph Node Mapping: Current Applications and Future Perspectives in Gynecology Malignant Tumors

Wang

Shao

et al. 2022

Front. Med.

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The sentinel lymph nodes (SLNs) is a group of lymph nodes initially involved in the metastatic spread of cancer cells. SLN mapping refers to intraoperative localization and biopsy of SLNs with specific tracers to assess lymph node metastases. It is widely used in a variety of tumor surgeries for its high sensitivity and high negative predictive value. In the evaluation of the status of lymph node metastases in gynecological malignancies, it has received increasingly more attention due to its minor invasiveness, few complications, and high diagnosis rate. The National Comprehensive Cancer Network (NCCN) guidelines provide an excellent introduction to the indications and methods of SLN techniques in vulvar, cervical, and endometrial cancers, but they provide little explanation about some specific issues. In this review, we summarize different dyes and injection methods and discuss the indications of application and the clinical trials of SLN mapping in gynecological malignant tumors, aiming to provide a reference for the rational application of sentinel techniques in gynecology malignant tumors before relevant guidelines are updated.

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Role of carbon nanoparticle suspension in sentinel lymph node biopsy for early‐stage cervical cancer: a prospective study

Cited by 18 publications

References 37 publications

The Application of Carbon Nanomaterials in Sensing, Imaging, Drug Delivery and Therapy for Gynecologic Cancers: An Overview

The Application of Carbon Nanomaterials in Sensing, Imaging, Drug Delivery and Therapy for Gynecologic Cancers: An Overview

Chylous ascites with lymphatic leakage localization: technical aspects and clinical applications

Sentinel Lymph Node Mapping: Current Applications and Future Perspectives in Gynecology Malignant Tumors

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