Role of Candida albicans on enamel demineralization and on acidogenic potential of Streptococcus mutans in vitro biofilms

Eidt, Gustavo; Andrade, Caroline Gomes de; Negrini, Thaís de Cássia; Arthur, Rodrigo Alex

doi:10.1590/1678-7757-2018-0593

Cited by 19 publications

(11 citation statements)

References 38 publications

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“…However, C. albicans reduced the biofilm formation capability of plaque of caries active S. mutans isolates. These results were consistent with the results of Eidt et al (2019) study which revealed that C. albicans can reduce both the cariogenic activity due to competition for nutrients and acidogenic potentials of S. mutans biofilms. Although S. mutans bacteria are considered the most cariogenic bacteria, studies showed that C. albicans can enhance the cariogenic potential of the S. mutans by altering the surrounding biofilm microenvironment to modulate the cariogenic potential of biofilms.…”

Section: Resultssupporting

confidence: 93%

Virulence traits-based behavior of Streptococcus mutans bacteria from dental plaque and dental caries conditions

Bakr

Tawfick

Mostafa

et al. 2021

MBJ

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Section: Resultssupporting

confidence: 93%

Virulence traits-based behavior of Streptococcus mutans bacteria from dental plaque and dental caries conditions

Bakr

Tawfick

Mostafa

et al. 2021

MBJ

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“…Bacteria have received most of the attention in microbiome studies, but other organisms like fungi are also important components. In the oral cavity, species like Candida albicans have been implicated in dental caries 37 , wherein it can adhere to the biofilms of the bacterial species Streptococcus mutans and both can act to demineralize tooth enamel 38 , 39 . One study showed two distinct mycotypes (clusters of samples based on the fungal composition), with one being dominated by Candida species, and the other with higher fungal diversity and Malassezia as the main genus 40 .…”

Section: Introductionmentioning

confidence: 99%

Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors

Willis

Saus

Iraola-Guzmán

et al. 2022

npj Biofilms Microbiomes

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The relevance of the human oral microbiome to our understanding of human health has grown in recent years as microbiome studies continue to develop. Given the links of the oral cavity with the digestive, respiratory and circulatory systems, the composition of the oral microbiome is relevant beyond just oral health, impacting systemic processes across the body. However, we still have a very limited understanding about intrinsic and extrinsic factors that shape the composition of the healthy oral microbiome. Here, we followed a citizen-science approach to assess the relative impact on the oral microbiome of selected biological, social, and lifestyle factors in 1648 Spanish individuals. We found that the oral microbiome changes across age, with middle ages showing a more homogeneous composition, and older ages showing more diverse microbiomes with increased representation of typically low abundance taxa. By measuring differences within and between groups of individuals sharing a given parameter, we were able to assess the relative impact of different factors in driving specific microbial compositions. Chronic health disorders present in the analyzed population were the most impactful factors, followed by smoking and the presence of yeasts in the oral cavity. Finally, we corroborate findings in the literature that relatives tend to have more similar oral microbiomes, and show for the first time a similar effect for classmates. Multiple intrinsic and extrinsic factors jointly shape the oral microbiome. Comparative analysis of metabarcoding data from a large sample set allows us to disentangle the individual effects.

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“…Interestingly, in vitro studies investigating the cariogenic potential of C. albicans have been conflicting; a recent study using dentine slabs reported that C. albicans increases dentine demineralization by enhancing the cariogenic potential of S. mutans (Sampaio et al, 2019). In contrast, other studies indicated that C. albicans raises the pH of the environment and has low enamel demineralization potential (Hubertine et al, 2016;Eidt et al, 2019). These discrepancies are most likely due to different experimental conditions used and are not accurately reflective of the oral environment.…”

Section: Introductionmentioning

confidence: 99%

The Role of Candida albicans Secreted Polysaccharides in Augmenting Streptococcus mutans Adherence and Mixed Biofilm Formation: In vitro and in vivo Studies

et al. 2020

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Candida Polysaccharides Augment Streptococcus Biofilm of co-infected mice compared to mice infected only with S. mutans. Collectively, the findings from this study strongly indicate that the secretion of polysacharides from C. albicans in the oral environment may impact the development of S. mutans biofilms, ultimately increasing dental caries and, therefore, Candida oral colonization should be considered as a factor in evaluating the risk of caries.

show abstract

Role of Candida albicans on enamel demineralization and on acidogenic potential of Streptococcus mutans in vitro biofilms

Cited by 19 publications

References 38 publications

Virulence traits-based behavior of Streptococcus mutans bacteria from dental plaque and dental caries conditions

Virulence traits-based behavior of Streptococcus mutans bacteria from dental plaque and dental caries conditions

Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors

The Role of Candida albicans Secreted Polysaccharides in Augmenting Streptococcus mutans Adherence and Mixed Biofilm Formation: In vitro and in vivo Studies

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