Role of Calcium and Beta-Adrenergic System in Control of Parathyroid Hormone Secretion

Kukreja, Subhash C.; Johnson, Patricia A.; Ayala, G.; Banerjee, Partha P.; Bowser, E. N.; Hargis, G. K.; Williams, George C.

doi:10.3181/00379727-151-39202

Cited by 44 publications

(22 citation statements)

References 5 publications

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“…The conclusion thus seems to be that hypocalcemia and epinephrine initially stimulate the release of PTH by two different triggering mechanisms. In accordance, findings have been reported (11,16) suggesting that the PTH responses to j-adrenergic agonists and to low plasma calcium concentrations are probably not mediated by the same receptors. However, a final common pathway could still exist.…”

Section: Discussionsupporting

confidence: 78%

“…Under these conditions, the hypocalcemiastimulated increase of PTH levels was not affected. Similar findings have been reported in rats (11). The conclusion thus seems to be that hypocalcemia and epinephrine initially stimulate the release of PTH by two different triggering mechanisms.…”

Section: Discussionsupporting

confidence: 77%

“…The fact that the blockade of 8-adrenergic receptors by propranolol does not modify basal PTH levels indicates that the parathyroid function in cows (but apparently not in man and rats [10,11]), is normally not under a fl-adrenergic tone. Also, propranolol added to bovine parathyroid cells could not consistently inhibit the release of PTH (16).…”

Section: Discussionmentioning

confidence: 99%

“…and apparently through interaction with 83-adrenergic receptor sites localized on parathyroid cells (9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

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Parathyroid Hormone Responses to Catecholamines and to Changes of Extracellular Calcium in Cows

Jw¹,

Ja²,

Wh³

et al. 1978

J. Clin. Invest.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

“…and apparently through interaction with 83-adrenergic receptor sites localized on parathyroid cells (9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Parathyroid Hormone Responses to Catecholamines and to Changes of Extracellular Calcium in Cows

Jw¹,

Ja²,

Wh³

et al. 1978

J. Clin. Invest.

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“…and suggested that they may be stored for parathor mone supply emergencies [Setoguti et al, 1981]. More recently, we have obtained further data that storage granules may be released promptly by epinephrine treatments, in spite of higher serum calcium levels to 10.9 mg/dl than normal control levels of about 9 mg/dl, and that they are more promptly released under hy pocalcemia [Setoguti et al, 1984], These results well consist with the current physiological or biochemical data that in the rat and cattle, |3-adrenergic agonists including epinephrine stimulate parathyroid hormone release in vivo [Fisher et al, 1973;Bowser et al, 1975;Kukreja et al, 1975Kukreja et al, , 1976Blum et al, 1978;Mayer ct al., 1979] as well as in vitro [Williams et al, 1973;Brown et al, 1977],…”

Section: Introductionsupporting

confidence: 75%

Effects of Pilocarpine Treatment and of Electrical Stimulation of the Vagus Nerve on the Rat Parathyroid Gland, with Special Reference to the Alteration of Storage Granules

Setoguti¹,

Inoue²,

Shin³

et al. 1985

Cells Tissues Organs

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Effects of pilocarpine treatment and of electrical vagal stimulation on the rat parathyroid were studied ultrastructurally. The number of type I storage granules with a narrow halo (NSG-I) and hat of type II storage granules having a wide halo (NSG-II) were calculated. After pilocarpine treatment, NSG-I gradually decreased and reached a minimum at 30 min; in contrast, NSG-II gradually increased and reached a maximum at 20 min, but thereafter it slightly decreased and instead vacuolar bodies increased. Excluding these alterations, the ultrastructure of parenchymal cells showed no remarkable changes. Electrical vagal stimulation furthermore confirmed these results. Acid phosphatase activity was occasionally found in storage granules of both types in control and experimental rats. It was concluded that storage granules normally may be transformed from type I into type II and finally into vacuolar bodies as a result of hydrolysis, and that these processes may be accelerated by parasympathetic stimulation.

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Effects of progesterone on postovariectomy bone loss in aged rats

Barengolts

Gajardo

Rosol

et al. 1990

Journal of Bone and Mineral Research

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The effects of progesterone on oophorectomy-induced bone loss in aged rats were evaluated. Female rats aged 12 months were divided into three groups: (1) sham-operated controls (SHAM); (2) oophorectomized (OVX); (3) OVX rats treated with progesterone (OVX + PROG). After 20 weeks the dry weight, bone ash, and calcium content of femur, tibia, and fourth lumbar vertebra were significantly lower in OVX than in sham rats. These reductions did not occur in OVX rats treated with PROG. There was no difference in the bone composition between the control and progesterone-treated rats. Vertebral bone histomorphometry showed increased bone resorption as well as increased bone formation parameters in OVX rats. Progesterone treatment inhibited the increased resorption indices, but the bone formation remained elevated. The results indicate that progesterone therapy prevents the postovariectomy bone loss in aged rats. The protective effect of progesterone is mediated by inhibition of bone resorption while maintaining the increased bone formation. These findings suggest that progesterone alone may be a valuable agent for management of postmenopausal osteoporosis.

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Role of Calcium and Beta-Adrenergic System in Control of Parathyroid Hormone Secretion

Cited by 44 publications

References 5 publications

Parathyroid Hormone Responses to Catecholamines and to Changes of Extracellular Calcium in Cows

Parathyroid Hormone Responses to Catecholamines and to Changes of Extracellular Calcium in Cows

Effects of Pilocarpine Treatment and of Electrical Stimulation of the Vagus Nerve on the Rat Parathyroid Gland, with Special Reference to the Alteration of Storage Granules

Effects of progesterone on postovariectomy bone loss in aged rats

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