Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin‐induced nephrotoxicity in rats

Abstract

We have investigated the effect of caffeic acid phenethyl ester (CAPE) on cisplatin-induced nephrotoxicity in rats. Administration of a single dose of cisplatin resulted in the elevation of blood urea nitrogen and creatinine in serum, as well as nitric oxide in kidney tissue of rats. Cisplatin also caused reduction of catalase (P < 0.0001), superoxide dismutase (P = 0.149) and glutathrone peroxidase (P < 0.0001) activities in kidney tissue. Although cisplatin caused elevation in malondialdehyde levels and myeloperoxidase activities in kidney tissue, they were not statistically significant. Caffeic acid phenethyl ester was found to be protective against cisplatin-induced antioxidant enzyme reductions. Treatment with free-radical scavenger CAPE attenuated the increase in plasma blood urea nitrogen and kidney nitric oxide levels, and showed histopathological protection against cisplatin-induced acute renal failure. Extensive epithelial cell vacuolization, swelling, desquamation and necrosis were observed in the kidney of the cisplatin-treated rat. There were also larger tubular lumens in cisplatin-treated rats than those of the control and the CAPE groups. Caffeic acid phenethyl ester caused a marked reduction in the extent of tubular damage. It is concluded that administration of cisplatin imposes an oxidative stress to renal tissue and CAPE confers protection against the oxidative damage associated with cisplatin. This mechanism may be attributed to its free-oxygen-radical scavenging activity.

Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats

“…The role of NO and RNS in cisplatin-induced nephrotoxicity has not been completely established. It has been shown that the renal content of nitrate/nitrite is increased in cisplatin-treated rats suggesting that NO is increased in these animals (25,26). The increase in renal ONOO -induced by cisplatin may be secondary to the increase in NO and O 2 production (Table II).…”

Effects of Different Doses of Hyperbaric Oxygen on Cisplatin-Induced Nephrotoxicity

“…[3,4] A number of antioxidants have been reported to reduce oxidative stress and prevent cisplatin nephrotoxicity. [5][6][7][8][9] Figure 1. Epithelial necrosis (short black arrow), cast formation, (long white arrow), and apoptotic cells (arrowhead) in the distal tubulus due to cisplatin nephrotoxicity (×200 HE; cisplatin group).…”

“…[3,4] Cisplatin is able to induce the formation of ROS and reduce the activity of antioxidant enzymes in renal tissue. [5][6][7][8][9] . The formation of excessive levels of ROS can lead to lethal or sub-lethal cellular damage.…”

Caffeic Acid Phenethyl Ester Protects Kidneys against Acetylsalicylic Acid Toxicity in Rats

“…In various studies, it has been used for its antioxidant, anti-inflammatory, anti-carcinogenic, anti-viral, anti-mutagenic, and immunomodulatory activities. [6][7][8][9][10][11][12] In addition, it has been shown to protect the kidneys from ischemiareperfusion injury, 13 cisplatin- 14 and lithium-induced 15 renal damage, diabetic oxidative damage, 16 and electromagnetic field and shock wave-induced oxidative stress. 17 The current due to the properties of CAPE, a drug may be useful in the prevention of ASA-induced renal pathology.…”