Role of Biomarkers as Predictors of Infection and Death in Neutropenic Febrile Patients After Hematopoietic Stem Cell Transplantation.

Massaro, Karin Schmidt Rodrigues; Costa, Sílvia Figueiredo

doi:10.4084/mjhid.2015.059

Cited by 4 publications

(2 citation statements)

References 40 publications

(48 reference statements)

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“…Было обнаружено, что исходно более высокий уровень СРБ был независимым неблагоприятным прогностическим фактором и коррелировал с показателями смертности, не связанной с рецидивом (p < 0,01), острой реакцией «трансплантат против хозяина» III-IV степени (p = 0,03), а также с низкими показателями общей выживаемости (p = 0,0018) [33,34]. J. Pavlu и соавт.…”

Section: с-реактивный белокunclassified

“…ПКТ является предшественником кальцитонина и представляет собой гликопротеид, состоящий из 116 аминокислот, с молекулярной массой 13-14 кДа [16, 23,33,39]. Синтез маркера происходит клетками щитовидной железы, печени, почек, мышечной и жировой ткани [40,41].…”

Section: прокальцитонинunclassified

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Role of Biochemical Inflammatory Markers in Patients with Chemotherapy-Induced Neutropenia

Dubinina¹,

Саржевский²,

Mel’nichenko³

2019

Клиническая онкогематология

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The growing number of autologous and allogeneic transplantations of bone marrow and hematopoietic stem cells as well as their technological eff ectiveness give rise to drug antineoplastic therapies with increased toxicity leading to development of complications. The most serious among this sort of complications are infections. Probability of infections in patients with chemotherapy-induced neutropenia reaches 90 %. In this context the search for an optimal marker of infectious complications becomes more and more important. The present review deals with basic biochemical infl ammatory markers and the analysis of trials assessing diagnostic and prognostic value of C-reactive protein, procalcitonin, and presepsin.

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Section: с-реактивный белокunclassified

Section: прокальцитонинunclassified

Role of Biochemical Inflammatory Markers in Patients with Chemotherapy-Induced Neutropenia

Dubinina¹,

Саржевский²,

Mel’nichenko³

2019

Клиническая онкогематология

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Early Warning of Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation Using Heart Rate Variability and Serum Biomarkers

Buchan

Herry

et al. 2022

Transplantation and Cellular Therapy

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Donor and recipient plasma follistatin levels are associated with acute GvHD in Blood and Marrow Transplant Clinical Trials Network 0402

Turcotte

DeFor

Newell

et al. 2017

Bone Marrow Transplant

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Follistatin is an angiogenic factor elevated in the circulation after allogeneic hematopoietic cell transplantation (HCT). Elevations in follistatin plasma concentrations are associated with the onset of and poor survival after acute graft versus host disease (aGVHD). Using data from the Blood and Marrow Transplant Clinical Trials Network 0402 study (n=247), we sought to further quantify the longitudinal associations between plasma follistatin levels in transplant recipients, as well as baseline HCT donor follistatin levels, and allogeneic HCT outcomes. Higher recipient baseline follistatin levels were predictive of development of aGVHD (P=0.04). High donor follistatin levels were also associated with the incidence of aGVHD (P<0.01). Elevated follistatin levels on day 28 were associated with the onset of grade II–IV aGVHD prior to day 28, higher one-year non-relapse mortality, (NRM), and lower overall survival (OS). In multivariate analyses, individuals with follistatin levels >1088 pg/mL at day 28 had a four-fold increased risk for NRM (RR=4.3, 95% CI 1.9–9.9, P<0.01) and a nearly three-fold increased overall risk for mortality (RR=2.8, 95% CI 1.5–5.2, P<0.01). Given the multiple roles of follistatin in tissue inflammation and repair, and the confirmation that this biomarker is predictive of important HCT outcomes, the pathobiology of these relationships need further study.

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Role of Biomarkers as Predictors of Infection and Death in Neutropenic Febrile Patients After Hematopoietic Stem Cell Transplantation.

Cited by 4 publications

References 40 publications

Role of Biochemical Inflammatory Markers in Patients with Chemotherapy-Induced Neutropenia

Role of Biochemical Inflammatory Markers in Patients with Chemotherapy-Induced Neutropenia

Early Warning of Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation Using Heart Rate Variability and Serum Biomarkers

Donor and recipient plasma follistatin levels are associated with acute GvHD in Blood and Marrow Transplant Clinical Trials Network 0402

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