Role of biologic glue repair of proximal aortic dissection in the development of early and midterm redissection of the aortic root

Kazui, Teruhisa; Washiyama, Naoki; Bashar, Abul Hasan Muhammad; Terada, Hitoshi; Suzuki, Kazunao; Yamashita, Katsushi; Takinami, Makoto

doi:10.1016/s0003-4975(01)02777-1

Cited by 152 publications

(88 citation statements)

References 21 publications

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“…It is effective in the treatment of several dermatological problems due to its antibacterial, antifungal and keratolytic effects [5,6]. Resorcinol solution in ethyl alcohol (Jessner's solution) is used in chemical peeling [7], and it has special medical use as biological glue (gelatin-resorcinol-formaldehyde glue) in cardiovascular surgery [8,9]. Despite its wide pharmaceutical applications, some side effects are also associated with it, for instance, mild skin irritation, skin redness, etc.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of Physical, Spectral and Thermal Properties of Biofield treated Resorcinol

Trivedi¹,

Branton²,

Trivedi³

et al. 2015

Organic Chem Curr Res

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Section: Introductionmentioning

confidence: 99%

Characterisation of Physical, Spectral and Thermal Properties of Biofield treated Resorcinol

Trivedi¹,

Branton²,

Trivedi³

et al. 2015

Organic Chem Curr Res

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“…However, with its increased use, long-term complications of using BioGlue have been reported, including late anastomotic pseudoaneurysm formation in small or large case series ( Table 3). Reports on reoperations for pseudoaneurysms have described necrotic, fibrosed, and excessively thinned aortic tissue found at the site of adhesive application (1,9,10,12,14,15,18,21,23). In 2001, Kazui reported a case of pseudoaneurysm at 5 months after initial repair of acute dissection (18).…”

Section: Discussionmentioning

confidence: 99%

Does BioGlue contribute to anastomotic pseudoaneurysm after thoracic aortic surgery?

Ziganshin

Guo

et al. 2017

J. Thorac. Dis.

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Background: Although bovine serum albumin-glutaraldehyde glue (BioGlue®) has been successfully used as a hemostatic adjunct in aortic surgical procedures, there are reports that it may lead to anastomotic pseudoaneurysm formation. We seek to examine if the use of BioGlue is associated with a high incidence of anastomotic pseudoaneurysm formation following surgical repair of thoracic aortic disease. Methods:We reviewed the medical records and follow-up computed tomography (CT) scans of patients from 2001 to 2015 in whom BioGlue was used during surgical repair of thoracic aortic disease to detect postoperative anastomotic pseudoaneurysm formation.Results: A total of 233 patients with BioGlue use were identified. Mean age was 63.5±14.0 years (median 66; range 14-88; 25-75%, IQR 54-74 years) and 149 were male (63.9%). Surgical indication was thoracic aortic aneurysm in 169 (72.5%) patients, aortic dissection in 49 (21.0%), intramural hematoma in 9 (3.9%), penetrating aortic ulcer in 3 (1.3%) and other in 3 (1.3%). Emergency/urgent surgery was performed in 68 cases (29.2%). Operative mortality was 7.3% (17/233). Re-exploration for bleeding and neurologic deficits occurred in 24 (10.3%) and 21 (9.0%) patients respectively. All operative survivors were followed (100%, 216/216) and CT follow-up was available in 81.9% (177/216) for a mean duration of 2.4 years (median 0.6; 25-75% IQR 0.2-3.6 years). Anastomotic pseudoaneurysm was detected in 1 patient (0.6%) at 3 years postoperatively. This was an elderly female with extremely frail tissues who underwent a reoperative ascending and arch replacement for dissection. Conclusions:The use of BioGlue in thoracic aortic surgery was not associated with excess incidence of anastomotic pseudoaneurysm formation following surgical repair of thoracic aortic disease. Its use need not be discouraged on this basis.

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“…The results of various investigations have shown the toxic potential of BioGlue on different tissue types. [33][34][35][36] The toxic effect of the BioGlue on phrenic nerve and on cardiac conduction tissues has been reported. 37 The toxicity of BioGlue increases when the glue is in contact with incisional tissue surfaces, especially those of the lung and the liver; however, this effect decreases when the glue is administered to the outer layer and vascular tissues.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Bioadhesive, BioGlue, on Impaired Colonic Anastomose Healing in Rats

Ekici

Akçay

Moray

2015

International Surgery

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Colonic anastomotic leakage is still a problem in general surgery practice. We sought to investigate the effect of a new tissue adhesive, BioGlue, on the healing of normal and impaired colonic anastomoses. Sixty-four rats were randomized into 4 groups. In all animals, a 1-cm segment of the left colon was resected, and an end-to-end sutured anastomosis was created. Animals were then divided into 2 groups: normal and impaired anastomosis. These 2 groups were further subdivided into 2 additional groups: animals that received BioGlue and those that did not. All rats received intraperitoneal injections of either 0.9% NaCl or 5-fluorouracil (5-FU). Anastomotic evaluation was done 7 days after surgery. Macroscopic healing, mechanical strength, and histopathologic healing parameters were evaluated. Leakage of the anastomosis was significantly higher in rats in the impaired group compared with those in the BioGlue groups (P ¼ 0.043). The adhesion formation score was significantly higher in rats in the impaired anastomosis group compared with the other groups. Bursting pressures were significantly lower in the impaired anastomosis group than in the other ones (P ¼ 0.001). Neoangiogenesis and fibroblast activity were different among the groups (P ¼ 0.001). Inflammatory cell infiltration and collagen deposition did not differ among the groups (P ¼ 0.07). Immediate postoperative intraperitoneal administration of 5-FU after colonic anastomosis inhibits intestinal wound healing. Covering colon anastomoses with BioGlue after suturing conferred beneficial effect on healing.

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Role of biologic glue repair of proximal aortic dissection in the development of early and midterm redissection of the aortic root

Cited by 152 publications

References 21 publications

Characterisation of Physical, Spectral and Thermal Properties of Biofield treated Resorcinol

Characterisation of Physical, Spectral and Thermal Properties of Biofield treated Resorcinol

Does BioGlue contribute to anastomotic pseudoaneurysm after thoracic aortic surgery?

Effect of the Bioadhesive, BioGlue, on Impaired Colonic Anastomose Healing in Rats

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