Role of Autonomous Neuropathy in Diabetic Bone Regeneration

Wagner, Johannes Maximilian; Wallner, Christoph; Becerikli, Mustafa; Reinkemeier, Felix; Gliński, M; Sogorski, Alexander; Huber, Julika; Dittfeld, Stephanie; Becker, Kathrin; Lehnhardt, Marcus; Dadras, Mehran

doi:10.3390/cells11040612

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…Sympathectomy in diabetic mice would induce the increased stromal cell-derived factor 1 level and decreased bone regeneration, but the specific molecular mechanism is unknown ( 48 ). Besides, no other study deeply evaluates the underlying mechanism of distal peripheral neuronal regulation on bone homeostasis and remodeling in diabetes.…”

Section: Discussionmentioning

confidence: 99%

Nerve conduction velocity is independently associated with bone mineral density in type 2 diabetes mellitus

Chen

Pan²,

Deng³

et al. 2023

Front. Endocrinol.

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AimThis study investigated the association between nerve conduction velocity (NCV) and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).MethodsThis study retrospectively collected medical data of T2DM patients who underwent dual-energy X-ray absorptiometry and nerve conduction study at the Shanghai Ruijin Hospital, Shanghai, China. The primary outcome was the total hip BMD T-score. The main independent variables were motor nerve conduction velocities (MCVs), sensory nerve conduction velocities (SCVs), and composite Z-scores of MCV and SCV. T2DM patients were divided into total hip BMD T-scores < -1 and total hip BMD T-scores ≥ -1 groups. The association between the primary outcome and main independent variables was evaluated by Pearson bivariate correlation and multivariate linear regression.Results195 female and 415 male patients with T2DM were identified. In male patients with T2DM, bilateral ulnar, median, and tibial MCVs and bilateral sural SCVs were lower in the total hip BMD T-score < -1 group than T-score ≥ -1 group (P < 0.05). Bilateral ulnar, median, and tibial MCVs, and bilateral sural SCVs showed positive correlations with total hip BMD T-score in male patients with T2DM (P < 0.05). Bilateral ulnar and tibial MCVs, bilateral sural SCVs, and composite MCV SCV and MSCV Z-scores were independently and positively associated with total hip BMD T-score in male patients with T2DM, respectively (P < 0.05). NCV did not show significant correlation with the total hip BMD T-score in female patients with T2DM.ConclusionNCV showed positive association with total hip BMD in male patients with T2DM. A decline in NCV indicates an elevated risk of low BMD (osteopenia/osteoporosis) in male patients with T2DM.

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Section: Discussionmentioning

confidence: 99%

Nerve conduction velocity is independently associated with bone mineral density in type 2 diabetes mellitus

Chen

Pan²,

Deng³

et al. 2023

Front. Endocrinol.

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Section: Transgenic Modelsmentioning

confidence: 99%

“…Leptin-deficient ob/ob mice were used in only one study [55], whereas leptin receptordeficient db/db mice were the main subjects in recent research [64][65][66]86] (see Table 1). For instance, Wagner et al compared the effects of transgenic diabetic mice with sympathectomized and wild-type animals [65]. In particular, they discovered striking similarities in diabetic and sympathectomized mice, leading to the hypothesis that diabetic neuropathy directly impedes the process of fracture healing.…”

Section: Transgenic Modelsmentioning

confidence: 99%

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Advantages and Limitations of Diabetic Bone Healing in Mouse Models: A Narrative Review

Maisenbacher,

Ehnert,

Histing

et al. 2023

Biomedicines

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Diabetes represents a major risk factor for impaired fracture healing. Type 2 diabetes mellitus is a growing epidemic worldwide, hence an increase in diabetes-related complications in fracture healing can be expected. However, the underlying mechanisms are not yet completely understood. Different mouse models are used in preclinical trauma research for fracture healing under diabetic conditions. The present review elucidates and evaluates the characteristics of state-of-the-art murine diabetic fracture healing models. Three major categories of murine models were identified: Streptozotocin-induced diabetes models, diet-induced diabetes models, and transgenic diabetes models. They all have specific advantages and limitations and affect bone physiology and fracture healing differently. The studies differed widely in their diabetic and fracture healing models and the chosen models were evaluated and discussed, raising concerns in the comparability of the current literature. Researchers should be aware of the presented advantages and limitations when choosing a murine diabetes model. Given the rapid increase in type II diabetics worldwide, our review found that there are a lack of models that sufficiently mimic the development of type II diabetes in adult patients over the years. We suggest that a model with a high-fat diet that accounts for 60% of the daily calorie intake over a period of at least 12 weeks provides the most accurate representation.

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Role of the Peripheral Nervous System in Skeletal Development and Regeneration: Controversies and Clinical Implications

Hassan

Horenberg

Coler‐Reilly

et al. 2023

Curr Osteoporos Rep

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Purpose of Review This review examines the diverse functional relationships that exist between the peripheral nervous system (PNS) and bone, including key advances over the past century that inform our efforts to translate these discoveries for skeletal repair. Recent Findings The innervation of the bone during development, homeostasis, and regeneration is highly patterned. Consistent with this, there have been nearly 100 studies over the past century that have used denervation approaches to isolate the effects of the different branches of the PNS on the bone. Overall, a common theme of balance emerges whereby an orchestration of both local and systemic neural functions must align to promote optimal skeletal repair while limiting negative consequences such as pain. Summary An improved understanding of the functional bidirectional pathways linking the PNS and bone has important implications for skeletal development and regeneration. Clinical advances over the next century will necessitate a rigorous identification of the mechanisms underlying these effects that is cautious not to oversimplify the in vivo condition in diverse states of health and disease.

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Role of Autonomous Neuropathy in Diabetic Bone Regeneration

Cited by 5 publications

References 38 publications

Nerve conduction velocity is independently associated with bone mineral density in type 2 diabetes mellitus

Nerve conduction velocity is independently associated with bone mineral density in type 2 diabetes mellitus

Advantages and Limitations of Diabetic Bone Healing in Mouse Models: A Narrative Review

Role of the Peripheral Nervous System in Skeletal Development and Regeneration: Controversies and Clinical Implications

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