Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection

Wesley, AlexanderJ.; Supp, Dorothy M.

doi:10.1089/wound.2013.0469

Cited by 82 publications

(56 citation statements)

References 58 publications

(52 reference statements)

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“…As there were no significant differences between the treated cells and the control (Figure S4), the enhanced wound closure in the HaCat cell monolayer can be attributed to both enhanced response and migration rate following lipid extract treatment. Multiple studies have shown the beneficial effects of PUFAs in wound healing assays (Alexander & Supp, ; Lee et al, ; Silva et al, ); however, their mechanism of action is dependent upon the precise composition of lipid mediator precursors (Gorjao et al, ). This work represents a foundation to elucidate the biological mechanisms that underlie the effects of acellular fish skin treatment on wound healing.…”

Section: Discussionmentioning

confidence: 99%

Wound healing grafts: Omega‐3 fatty acid lipid content differentiates the lipid profiles of acellular Atlantic cod skin from traditional dermal substitutes

Kotronoulas

Jónasdóttir

Sigurðardóttir

et al. 2020

J Tissue Eng Regen Med

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Acellular fish skin (ACS) has emerged as a dermal substitute used to promote wound healing with decreased scar formation and pain relief that may be due to polyunsaturated fatty acid (PUFA) content. However, the PUFA content of ACS is still unknown. The aim of this study was to compare the total fatty acids and lipid profiles of ACS to two bovine‐based grafts and standard of care human cadaver skin (HCS). Furthermore, there was also the goal to assess the capability of ACS lipid content to enhance wound healing. The fatty acid analysis was performed with GC–FID, and an LC–MS untargeted method was developed in order to the analyse the lipid profiles of the grafts was. The enhancement of wound healing by the ACS extract was investigated in vitro on HaCat cells. Our results showed that ACS had the highest content of PUFA (27.0 ± 1.43% of their total fatty acids), followed by HCS (20.6 ± 3.9%). The two grafts of bovine origin presented insignificant PUFA amounts. The majority of the PUFAs found in ACS were omega‐3, and in HCS, they were omega‐6. The untargeted lipidomics analysis demonstrated that ACS grafts were characterized by phosphatidylcholine containing either 20:5 or 22:6 omega‐3 PUFA. The ACS lipid extract increased the HaCat cells migration and enhanced wound closure 4 hr earlier versus control. Our study demonstrated that ACS has a lipid profile that is distinct from other wound healing grafts, that PUFAs are maintained in ACS post‐processing as phosphatidylcholine, and that ACS lipid content influences wound healing properties.

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Section: Discussionmentioning

confidence: 99%

Wound healing grafts: Omega‐3 fatty acid lipid content differentiates the lipid profiles of acellular Atlantic cod skin from traditional dermal substitutes

Kotronoulas

Jónasdóttir

Sigurðardóttir

et al. 2020

J Tissue Eng Regen Med

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“…A favourable immunomodulatory action is also attributed to such ingredients as the above-mentioned: copper, zinc, iron, vitamins B2, B6, C and E. Immunomodulatory ingredients can be added both to the mixtures intended for nutrition via the gastrointestinal tract (oral or enteral) and for parenteral nutrition. [21][22][23][24][25] It has been proved that the use of mixtures of nutrients with immunomodulatory action diminishes the risk of infection and shortens the total duration of hospital stay. Particularly favourable effects were achieved among the patients with concomitant malnutrition, compared to the well-nourished patients.…”

Section: Discussionmentioning

confidence: 99%

Role of nutritional intervention in negative pressure wound therapy (NPWT). Case report of patient treated by 'open abdomen' method.

Kuczyńska

2017

NPWTJ

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Abstract-Introduction: Wound healing process depends on many factors. As it has been proved many times before, nutrition is one of the key factors in wound healing therapy. When there is an insufficient supply of nutrients and malnutrition, wound healing processes slow down and the inflammatory phase is prolonged, which requires high energy expenditure and as a consequence, may lead to the loss of lean body mass and the development of sarcopenia and cachexia. This promotes the formation of non-healing chronic wounds.In this paper we would like to emphasize the role of nutrition, as an integral part of wound healing processes, which should encompass the current metabolic needs associated with patient's clinical condition.Case report: This case describes a young male patient with gastrointestinal tract insufficiency and an extensive postoperative wound treated by the open abdomen method. In the course of increased catabolism, water and electrolyte loss and disturbances as well as nutritional insufficiencies, body mass loss and progressive cachexia occurred in this patient and, as a consequence, the wound healing processes was significantly diminished.Conclusions: Inducing and maintaining the anabolic processes in the organism and control of the enhanced catabolism in response to metabolic stress or injury are essential actions in optimizing the treatment and healing process. These are possible to achieve by the early introduction of balanced and individualized nutritional treatment regimens, provision of the energy and appropriate nutrients, which enables the restoration of lean body mass and stimulation of the healing processes.

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“…Polyethylene glycol (PEG), as a biocompatible polymer, has been widely used to modify hydrophobic polymers to improve their solubility . As a semiessential amino acid in human, l ‐arginine plays an important role in biological activity such as cell division and wounds healing . Therefore, the functionalization of l ‐arginine on PC‐based polymers may significantly enhance their biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

“…15,16 As a semiessential amino acid in human, L-arginine plays an important role in biological activity such as cell division and wounds healing. 17 Therefore, the functionalization of L-arginine on PC-based polymers may significantly enhance their biocompatibility. In addition, amine-abounded branched polymers such as the hyperbranched poly(amine-ester), poly(propyletherimine) dendrimers, and poly(amidoamine) present significant inherent photoluminescent properties.…”

Section: Introductionmentioning

confidence: 99%

Photoluminescent arginine‐functionalized polycitrate with enhanced cell activity and hemocompatibility for live cell bioimaging

Wang

Guo

Peter

et al. 2018

J Biomedical Materials Res

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Development of biodegradable and highly biocompatible polymer with intrinsical photoluminescence and high photostability for real‐time live cell bioimaging has attracted much attention recently. Here, a biodegradable and amphiphilic poly (citrate)‐co‐poly (ethylene glycol) (PEG) grafted with arginine (PCGA) polymer with intrinsical fluorescence was synthesized for targeted live cell bioimaging. The physicochemical structure, photoluminescent properties, hemocompatibility, cytotoxicity, and fluorescent bioimaging studies in live cells were determined in detail. PCGA showed a significantly high hemocompatibility, low cytotoxicity, and excellent photostability, which allows for imaging the live cells attachment and proliferation. Furthermore, PCGA could efficiently enhance cell attachment and proliferation due to the presence of arginine, suggesting their high cellular biocompatibility. Importantly, PCGA could selectively stain the lysosome in cells. Our results demonstrated that the amino acid‐based polymer functionalization may be an important strategy to develop multifunctional biomaterials with enhanced biocompatibility for targeted bioimaging, cancer therapy, and regenerative medicine. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3175–3184, 2018.

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Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection

Cited by 82 publications

References 58 publications

Wound healing grafts: Omega‐3 fatty acid lipid content differentiates the lipid profiles of acellular Atlantic cod skin from traditional dermal substitutes

Wound healing grafts: Omega‐3 fatty acid lipid content differentiates the lipid profiles of acellular Atlantic cod skin from traditional dermal substitutes

Role of nutritional intervention in negative pressure wound therapy (NPWT). Case report of patient treated by 'open abdomen' method.

Photoluminescent arginine‐functionalized polycitrate with enhanced cell activity and hemocompatibility for live cell bioimaging

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