Role of antimicrobial photodynamic therapy in reducing subgingival oral yeasts colonization in patients with peri-implant mucositis

Shetty, Bharathraj; Ali, Dena; Ahmed, Suhaib; Ibraheem, Wael; Preethanath, Reghunathan S.; Vellappally, Sajith; Divakar, Darshan Devang

doi:10.1016/j.pdpdt.2022.102803

Cited by 9 publications

(24 citation statements)

References 27 publications

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“…SMI was performed by mechanical instrumentation using plastic curettes (Al‐Sowygh, 2017; Javed et al, 2017) or Gracey curettes (Shetty et al, 2022), mechanical instrumentation using titanium curettes and polishing rubber caps with paste (Deeb et al, 2020), and mechanical debridement without further specification regarding the applied instrument or technique (Al Rifaiy et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

“…In this SR, the meta‐analysis revealed that SMI in conjunction with adjunctive aPDT led to a significantly reduced PI compared with SMI alone, while BOP and PD remained unchanged. These are somewhat conflicting results, and they suggest that the overall effect of improved oral hygiene may not be effective enough to facilitate disease resolution of PIM when tobacco is consumed (Javed et al, 2017; Al Rifaiy et al, 2018; Deeb et al, 2020; Shetty et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of professionally administered chemical agents as an adjunctive treatment to sub‐marginal instrumentation during the therapy of peri‐implant mucositis

Dommisch

Hoedke

Vallés

et al. 2022

J Clinic Periodontology

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Aim To evaluate the efficacy of professionally administered chemical agents as an adjunctive treatment to sub‐marginal instrumentation (SMI) in the therapy of peri‐implant mucositis. Materials and Methods The primary outcome criteria were reduction in bleeding on probing (BOP), whereas resolution of disease, elimination of suppuration, including suppuration on probing, reduction of peri‐implant probing pocket depth, reduction of plaque, and patient‐reported outcome measures were considered as secondary outcome parameters. A literature search was performed on three electronic databases (01/1980 to 05/2022) focused on clinical studies with at least 3 months of follow‐up, and meta‐analyses were performed when appropriate. Results From a total of 139 publications, 40 articles were identified for full‐text reading, and 5 randomized controlled clinical trials (RCTs) on antimicrobial photodynamic therapy (aPDT), 1 RCT on chlorhexidine (CHX), and 1 RCT on sodium hypochlorite (NaOCl) were included. Three studies had a low risk of bias and four had a mid‐level (some concerns) risk of bias. The application of aPDT, 0.95% NaOCl, or 0.12% CHX as an adjunctive treatment to SMI showed no difference in changes in BOP and PD compared with SMI alone (p > .05). Conclusions Within the limitations of this review and based on a low level of evidence from seven RCTs, it is concluded that the professional adjunctive topical application of aPDT, 0.95% NaOCl, and 0.12% CHX may not be effective to improve changes for BOP and PD when compared with SMI alone.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy of professionally administered chemical agents as an adjunctive treatment to sub‐marginal instrumentation during the therapy of peri‐implant mucositis

Dommisch

Hoedke

Vallés

et al. 2022

J Clinic Periodontology

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“…aPDT has been introduced as a potential treatment against the viral diseases when used as an adjunctive treatment alongside the antiviral medications with promising results by the recently published RCTs ( Ajmal, 2021 ; Ramalho et al, 2021 ; Shetty et al, 2022 ; Table 6 ). These studies have all used methylene blue as a PS activated with a red wavelength of 660 nm.…”

Section: Applications Of Apdt In the Treatment Of Oral Viral Infectionsmentioning

confidence: 99%

“…Vellappally et al and Ajmal investigated the effect of aPDT (methylene blue 0.005% as PS) for the treatment of herpes labialis in adolescent population. Both demonstrated that using aPDT in adjunct with acyclovir reduced the pain scores as a parameter mostly important for patients in addition to the molecular level parameters including quantified HSV-1, IL-6, and TNF-α ( Ajmal, 2021 ; Shetty et al, 2022 ). In another RCT by Ramalho et al, with similar methodology on the adult population, application of adjunctive aPDT yielded no substantial difference compared to the acyclovir in terms of lesion healing time, edema and pain.…”

Section: Applications Of Apdt In the Treatment Of Oral Viral Infectionsmentioning

confidence: 99%

“…In recent years several clinical randomized controlled trials have also been designed to evaluate the efficacy of this method in treating oral infectious diseases such as periodontitis ( Wadhwa et al, 2021 ; Arsic et al, 2022 ), periimplantitis ( Shatha-Subhi et al, 2022 ; Shetty et al, 2022 ), halitosis ( Llanos do Vale et al, 2021 ; Romero et al, 2021 ), recurrent herpes labialis ( Ramalho et al, 2021 ), root canal disinfection ( Asnaashari et al, 2017 ; Okamoto et al, 2020 ), oral plaque and caries control ( Nikinmaa et al, 2021 ), and treating fungal diseases caused by candida albicans ( Alves et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Clinical applications of antimicrobial photodynamic therapy in dentistry

et al. 2023

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Given the emergence of resistant bacterial strains and novel microorganisms that globally threaten human life, moving toward new treatment modalities for microbial infections has become a priority more than ever. Antimicrobial photodynamic therapy (aPDT) has been introduced as a promising and non-invasive local and adjuvant treatment in several oral infectious diseases. Its efficacy for elimination of bacterial, fungal, and viral infections and key pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Candida albicans, and Enterococcus faecalis have been investigated by many invitro and clinical studies. Researchers have also investigated methods of increasing the efficacy of such treatment modalities by amazing developments in the production of natural, nano based, and targeted photosensitizers. As clinical studies have an important role in paving the way towards evidence-based applications in oral infection treatment by this method, the current review aimed to provide an overall view of potential clinical applications in this field and summarize the data of available randomized controlled clinical studies conducted on the applications of aPDT in dentistry and investigate its future horizons in the dental practice. Four databases including PubMed (Medline), Web of Science, Scopus and Embase were searched up to September 2022 to retrieve related clinical studies. There are several clinical studies reporting aPDT as an effective adjunctive treatment modality capable of reducing pathogenic bacterial loads in periodontal and peri-implant, and persistent endodontic infections. Clinical evidence also reveals a therapeutic potential for aPDT in prevention and reduction of cariogenic organisms and treatment of infections with fungal or viral origins, however, the number of randomized clinical studies in these groups are much less. Altogether, various photosensitizers have been used and it is still not possible to recommend specific irradiation parameters due to heterogenicity among studies. Reaching effective clinical protocols and parameters of this treatment is difficult and requires further high quality randomized controlled trials focusing on specific PS and irradiation parameters that have shown to have clinical efficacy and are able to reduce pathogenic bacterial loads with sufficient follow-up periods.

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Impact of antimicrobial photodynamic therapy on the bond-strength and penetration of endodontic sealers: A systematic review

Almadi

2023

Photodiagnosis and Photodynamic Therapy

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Role of antimicrobial photodynamic therapy in reducing subgingival oral yeasts colonization in patients with peri-implant mucositis

Cited by 9 publications

References 27 publications

Efficacy of professionally administered chemical agents as an adjunctive treatment to sub‐marginal instrumentation during the therapy of peri‐implant mucositis

Efficacy of professionally administered chemical agents as an adjunctive treatment to sub‐marginal instrumentation during the therapy of peri‐implant mucositis

Clinical applications of antimicrobial photodynamic therapy in dentistry

Impact of antimicrobial photodynamic therapy on the bond-strength and penetration of endodontic sealers: A systematic review

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