Role of Antibiotics in Therapy of Acne

Robinson, Harry M.

doi:10.1001/archderm.1954.01540160016003

Cited by 24 publications

(5 citation statements)

References 3 publications

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“…Following the approval of doxycycline by the US Food and Drug Administration (FDA) in 1967, the first evidence for the anti‐inflammatory properties of antimicrobials was presented in a German study in 1974 8 . Other types of antimicrobials, including macrolides, sulphonamides and fluoroquinolones, were also introduced for use in acne, with the main purpose envisaged to kill Propionibacterium acnes (P. acnes) 9 . Currently, the tetracyclines and macrolides remain a part of the mainstream for the treatment of mild‐to‐moderate inflammatory acne, mainly based on their anti‐inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic resistance in acne: changes, consequences and concerns

Karadağ

Kayıran

et al. 2020

Acad Dermatol Venereol

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Antibiotic resistance in acne was first observed in the 1970s and has been a major concern in dermatology since the 1980s. The resistance rates and types of antimicrobials have subsequently shown great variations in regions and countries. Illustrative of this is the resistance to topical erythromycin and clindamycin which continues to be a problem worldwide, while resistance to systemic treatment with tetracyclines has remained low during the past decade. The resistance for the newer macrolides like azithromycin and clarithromycin has been increasing. The results of antibiotic resistance may include treatment failure of acne, disturbance of skin microbiota, induction of opportunistic pathogens locally and systemically, and dissemination of resistant strains to both healthcare personnel and the general population. The ensuing complications, such as aggravated opportunistic infections caused by Propionibacterium acnes and the emergence of multiresistant superbugs, have not yet been confirmed.

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Section: Introductionmentioning

confidence: 99%

Antibiotic resistance in acne: changes, consequences and concerns

Karadağ

Kayıran

et al. 2020

Acad Dermatol Venereol

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“…Numerous subsequent studies consistently found that long‐term treatment with tetracycline brought about significant improvement, leading to the broadening of its use 19,20 . Tetracyclines were ultimately determined to have superior clinical efficacy compared with alternative available drugs, with erythromycin placing in the runner‐up spot 21–23 . In the 1970s, newer tetracyclines such as doxycycline and minocycline were synthesized and found to be even more effective 24,25 .…”

Section: Mid‐20th Century – the “Golden Age” Of Antibioticsmentioning

confidence: 99%

Acne and antibiotics: a look back

Weiner

James

2021

Int J Dermatology

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Section: From Acne Microbacillus To P Acnes: Facts Controversies Anmentioning

confidence: 99%

“…Robinson [219] showed that oxytetracycline, chlortetracycline and erythromycin were the drugs of choice to treat acne vulgaris and acne conglobata. He did no recommend the use of topical antibiotics [219]. In the following years, additional works reinforced the credit of antibiotics and therefore emphasized the role of microorganisms even though their exact roles remained unknown.…”

Section: From Acne Microbacillus To P Acnes: Facts Controversies Anmentioning

confidence: 99%

Acne Pathogenesis: History of Concepts

Tilles¹

2014

Dermatology

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From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as mandatory. In the 1970s, the onset of isotretinoin dramatically improved acne management. It also provided great opportunities for a better understanding of the pathogenic factors of acne. This study analyzes their genesis and development from the seminal contributions until recent advances.

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Role of Antibiotics in Therapy of Acne

Cited by 24 publications

References 3 publications

Antibiotic resistance in acne: changes, consequences and concerns

Antibiotic resistance in acne: changes, consequences and concerns

Acne and antibiotics: a look back

Acne Pathogenesis: History of Concepts

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