Antibiotic resistance in acne: changes, consequences and concerns

Karadağ, Ayşe Serap; Kayıran, Melek Aslan; Wu, Chieh‐Hsin; Chen, W.; Parish, Lawrence Charles

doi:10.1111/jdv.16686

Cited by 58 publications

(66 citation statements)

References 70 publications

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“…Antibiotic resistance P. acnes was first reported by Leyden in 1976 and raised from 20% in 1978 to 65% today, even 90% in some countries like China and India. [17][18][19][20][21] The resistance to macrolides is more pronounced. [21][22][23] Topical antibiotics like erythromycin and clindamycin have caused an increase in antibiotic-resistant bacteria both in the applied and other areas.…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19][20][21] The resistance to macrolides is more pronounced. [21][22][23] Topical antibiotics like erythromycin and clindamycin have caused an increase in antibiotic-resistant bacteria both in the applied and other areas. 21,24,25 On the other hand, systemic antibiotics were found to cause microflora to gain resistance throughout the body.…”

Section: Discussionmentioning

confidence: 99%

“…[21][22][23] Topical antibiotics like erythromycin and clindamycin have caused an increase in antibiotic-resistant bacteria both in the applied and other areas. 21,24,25 On the other hand, systemic antibiotics were found to cause microflora to gain resistance throughout the body. 21,22,26 This resistance is transmitted not only to the treated patients, but also to their close contacts.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of dermatologists and family physicians in terms of prescribing antibiotics for the treatment of acne vulgaris

Kayıran

Karadağ

Mutlu

et al. 2020

Dermatologic Therapy

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Acne vulgaris (AV) is a common skin disease that is treated both with dermatologists and family physicians (FPs) with different strategies. To assess the antibiotics that are frequently preferred in AV treatment, and the differences between the FPs and dermatologists in treatment were investigated. The physicians were informed about the study, and sent over the internet a multiple-choice questionnaire that consists of 29 questions in total. Afterwards, the answers provided were compared. 201 dermatologists and 147 FPs participated in the study. Dermatologists were found to have preferred topical erythromycin, nadifloxacin, clindamycin, and tetracycline, and systematically doxycycline and azithromycin in adult patients, whereas the FPs were found to have preferred mupirocin, fusidic acid (FA), and oxytetracycline, and systematically tetracycline. Dermatologists were found to have recommended topical clindamycin and erythromycin in pregnant/breastfeeding AV patients, whereas the FPs were found to have recommended FA. Dermatologists were found to have continued the antibiotics for 8 to 12 weeks, whereas the FPs were found to have continued for 1 to 4 weeks. The dermatologists preferred systemic antibiotics in cases with back involvement, moderate to severe AV, and that the FPs preferred them in severe AV. The dermatologists considered that the use of antibiotics alone or long-term were important factors causing antibiotic resistance. There were significant differences between the approaches of dermatologists and FPs to AV treatment. FPs were found to have insufficient information about prevention of antibiotic resistance. Therefore, we think that the continuous training of FPs on dermatology will be beneficial.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison of dermatologists and family physicians in terms of prescribing antibiotics for the treatment of acne vulgaris

Kayıran

Karadağ

Mutlu

et al. 2020

Dermatologic Therapy

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Section: Reduction Of the Effective Dose Of Clindamycin Against C Acmentioning

confidence: 99%

“…Clindamycin is one of the common antibiotics for acne vulgaris [28]. However, the antibiotic single-agent therapy can result in the rapid development of clinically significant antibiotic resistance [28]. Several carbohydrates, for example sucrose, have been added into antibiotic (amoxicillin) formulae as ingredients [29].…”

Section: Reduction Of the Effective Dose Of Clindamycin Against C Acmentioning

confidence: 99%

PEG-8 Laurate Fermentation of Staphylococcus epidermidis Reduces the Required Dose of Clindamycin Against Cutibacterium acnes

Marito

Keshari

Huang

2020

IJMS

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The probiotic activity of skin Staphylococcus epidermidis (S. epidermidis) bacteria can elicit diverse biological functions via the fermentation of various carbon sources. Here, we found that polyethylene glycol (PEG)-8 Laurate, a carbon-rich molecule, can selectively induce the fermentation of S. epidermidis, not Cutibacterium acnes (C. acnes), a bacterium associated with acne vulgaris. The PEG-8 Laurate fermentation of S. epidermidis remarkably diminished the growth of C. acnes and the C. acnes-induced production of pro-inflammatory macrophage-inflammatory protein 2 (MIP-2) cytokines in mice. Fermentation media enhanced the anti-C. acnes activity of a low dose (0.1%) clindamycin, a prescription antibiotic commonly used to treat acne vulgaris, in terms of the suppression of C. acnes colonization and MIP-2 production. Furthermore, PEG-8 Laurate fermentation of S. epidermidis boosted the activity of 0.1% clindamycin to reduce the sizes of C. acnes colonies. Our results demonstrated, for the first time, that the PEG-8 Laurate fermentation of S. epidermidis displayed the adjuvant effect on promoting the efficacy of low-dose clindamycin against C. acnes. Targeting C. acnes by lowering the required doses of antibiotics may avoid the risk of creating drug-resistant C. acnes and maintain the bacterial homeostasis in the skin microbiome, leading to a novel modality for the antibiotic treatment of acne vulgaris.

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Topical, light-based, and complementary interventions for acne: an overview of systematic reviews

Yuan

Wang

Xia

et al. 2021

Cochrane Database of Systematic Reviews

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Antibiotic resistance in acne: changes, consequences and concerns

Cited by 58 publications

References 70 publications

Comparison of dermatologists and family physicians in terms of prescribing antibiotics for the treatment of acne vulgaris

Comparison of dermatologists and family physicians in terms of prescribing antibiotics for the treatment of acne vulgaris

PEG-8 Laurate Fermentation of Staphylococcus epidermidis Reduces the Required Dose of Clindamycin Against Cutibacterium acnes

Topical, light-based, and complementary interventions for acne: an overview of systematic reviews

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