Role of Antibiotics in the Treatment and Prevention of Acute and Recurrent Cholangitis

Hazel, Susan J.; Speelman, Peter; Tytgat, G. N. J.; Dankert, J.; Leeuwen, D. J. Van

doi:10.1093/clinids/19.2.279

Cited by 84 publications

(46 citation statements)

References 63 publications

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“…Ciprofloxacin was chosen in our study because of its efficacy against most Gram-negative organisms (E. coli and Klebsiella spp.) which are the pathogens most frequently found in biliary tract infection [5][6][12][13][16][17] and its penetration into the obstructive biliary tree [6] . We found 12 Gram-positive bacteria in bile cultures (Streptococcus viridans and Enterococcus spp.)…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of cholangitis is 0.8%-19%, and its mortality rate is 10% [4] . The role of prophylactic antibiotics after ERCP has been recently assessed in several placebo-controlled randomized trials [5][6][7][8][9] . This procedure plays an essential part in high risk patients with prosthetic valve and history of endocarditis, obstructed bile duct, pancreatic cystic lesion and inadequate common bile duct drainage [3,10] .…”

Section: Introductionmentioning

confidence: 99%

“…Most of the bacterial florae in bile of patients with cholangitis and asymptomatic bacterobilia are Gram-negative organisms such as E. coli, Klebsella spp. and Gram-positive organisms such as Enterococcus fecalis [5][6][11][12][13] . The choice of an antibiotic regimen should be able to cover the Gramnegative bacteria and effectively penetrates the obstructed biliary tree.…”

Section: Introductionmentioning

confidence: 99%

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Role of ciprofloxacin in patients with cholestasis after endoscopic retrograde cholangiopancreatography

Ratanachu‐ek

Prajanphanit²,

Leelawat³

et al. 2007

WJG

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AIM: To d e t e r m i n e t h e r o l e o f c i p r o f l o x a c i n i n reducing cholangitis in cholestatic patients with adequate biliary drainage after endoscopic retrograde cholangiopancreatography (ERCP). METHODS:A ra n d o m i z e d , c o n t r o l l e d t r i a l w a s performed in 48 cholestatic patients at Rajavithi Hospital (Tertiary Referral Center for ERCP: 600 cases per year). All the 48 patients received 200 mg ciprofloxacin intravenous injection for 30 min before starting any procedures, and then were randomly divided in two groups. Twenty-two patients in study group continually received ciprofloxacin until 48 h after ERCP. Causes of biliary obstruction, bacteriology of bile and blood (in cholangitis) and clinical cholangitis were recorded. RESULTS:Forty-eight patients were enrolled and divided into continuous ciprofloxacin treatment group (n = 22) and discontinuous ciprofloxacin treatment group (n = 26). During ERCP, stones were found in 22 patients, malignant diseases in 24 patients and other pathologic lesions in 5 patients. One (4.5%) of the 22 patients who received ciprofloxacin and 2 (6.3%) of the 26 patients who discontinued ciprofloxacin after ERCP developed cholangitis (relative risk = 0.71; 95% CI = 0.14-3.65; P = 0.88). Bacterobilia was found in 27 (56.3%) out of 48 patients. E. coli and Streptococcus viridans were the most common organisms. CONCLUSION:

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of ciprofloxacin in patients with cholestasis after endoscopic retrograde cholangiopancreatography

Ratanachu‐ek

Prajanphanit²,

Leelawat³

et al. 2007

WJG

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“…Gramnegative Darmbakterien sind die häufigsten Erreger. Als häufigster grampositiver Erreger lassen sich Enterobacter und als Anaerobier Bacteroides und Clostriden nachweisen [22]. Die Mortalität der akuten Cholangitis wird nach Schwere des Krankheitsbildes und der Komorbidität mit bis zu 88% angegeben [23].…”

Section: Akute Gallensteinbedingte Cholangitisunclassified

“…Ampicillin/Gentamycin, Cephalosporine der 3. Generation, Imipenem oder Ciprofloxacin [22,30]. Bei der klinisch milden Form der Cholangitis ist eine Infektionskontrolle durch alleinige antibiotische Therapie innerhalb von 24-48 h zu erwarten [20].…”

Section: Akute Gallensteinbedingte Cholangitisunclassified

Cholelithiasis

Heller¹,

Sauerbruch²

2002

Visc Med

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The incidence of complications in patients with symptomatic gallstone disease is about 1% per year. The most frequent complication is acute cholecystitis. Less frequent complications are acute cholangitis, biliary pancreatitis, Mirizzi syndrome and gallstone ileus. This article reviews the current knowledge of the diagnosis and therapy of these complications including the recommendations of consensus conferences.

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Review of the Tokyo Guidelines 2018: Antimicrobial Therapy for Acute Cholangitis and Cholecystitis

Buckman

Mazuski

2019

JAMA Surg

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Role of Antibiotics in the Treatment and Prevention of Acute and Recurrent Cholangitis

Cited by 84 publications

References 63 publications

Role of ciprofloxacin in patients with cholestasis after endoscopic retrograde cholangiopancreatography

Role of ciprofloxacin in patients with cholestasis after endoscopic retrograde cholangiopancreatography

Cholelithiasis

Review of the Tokyo Guidelines 2018: Antimicrobial Therapy for Acute Cholangitis and Cholecystitis

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