Role of Angptl4 in vascular permeability and inflammation

Guo, Liang; Li, Shaoying; Ji, Fuyun; Zhao, Yunfeng; Zhong, Yu; Lv, Xuejun; Wu, Xueling; Qian, Guisheng

doi:10.1007/s00011-013-0678-0

Cited by 93 publications

(82 citation statements)

References 50 publications

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“…In the bloodstream, oligomerized N-terminal and full-length ANGPTL4 protein inhibits the activity of blood lipoprotein lipase thus influencing lipid metabolism [3e9]. However, in endothelial cells the C-terminus of ANGPTL4 represents a master regulator of vascular permeability and angiogenesis, as reviewed by Guo et al [33]. The C-terminus of ANGPTL4 alone has been shown to be sufficient to suppress angiogenesis through inhibiting the Raf/MEK/ERK signaling pathway in endothelial cells [34].…”

Section: Discussionmentioning

confidence: 98%

Angiopoietin-like protein 4 significantly predicts future cardiovascular events in coronary patients

et al. 2014

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Section: Discussionmentioning

confidence: 98%

Angiopoietin-like protein 4 significantly predicts future cardiovascular events in coronary patients

et al. 2014

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“…These genes included ANGPTL4, TCF7L2, and FOXP1. ANGPTL4 encodes a secreted protein which is involved in vascular permeability, angiogenesis, inflammatory responses, and glucose homeostasis in different tissues (18,19). TCF7L2 plays a key role in the Wnt signaling pathway and is involved in glucose homeostasis (20).…”

Section: Discussionmentioning

confidence: 99%

Gene expression changes in bioceramic paste-treated human dental pulp cells

Torun

Demirkaya

et al. 2016

J Oral Sci

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Abstract:We evaluated the gene expression profiles of human dental pulp cells exposed to iRoot BP using microarray after 24 and 72 h. The results were verified using quantitative reverse transcriptase PCR analysis. Of the 36,000 transcripts arrayed, 21 were up-regulated and 15 were down-regulated by more than two fold. The largest group of up-regulated genes included those involved in nucleobase-containing compound metabolic processes, cell communication, protein metabolic processes, developmental processes, and biological regulation. The largest groups of down-regulated genes were those involved in cell communication, development, and biological regulation processes. In conclusion, iRoot BP affects the expression of genes involved in different biological processes in human dental pulp cells. (J Oral Sci 58, 307-315, 2016)

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“…It was reported that ANGPTL4 participates in many inflammation responses, especially in lung inflammation and alveolar epithelial cell death, which could lead to ALI [24,25]. Whether it also plays an important role in H1N1-induced ALI remains unclear.…”

Section: Resultsmentioning

confidence: 99%

Effect of Maxing Shigan Tang on H1N1 Influenza A Virus-Associated Acute Lung Injury in Mice

et al. 2016

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Objective: This study is aimed at examining the effects of Maxing Shigan Tang (MST) treatment on H1N1-associated acute lung injury (ALI) and exploring the possible mechanism. Material and Methods: Mice were randomly divided into a control group, model group, peroxisomal proliferator activator receptor γ (PPARγ) inhibition group (PPARγ-), PPARγ activation group (PPARγ+), and MST group. Influenza A (H1N1) virus of the Fort Monmouth 1 (FM1) strain was used to induce an ALI mice model. Hematoxylin and eosin staining was performed to investigate the effect of MST treatment on H1N1-associated ALI. Cell apoptosis of lung tissues of each group were conducted through transferase-mediated dUTP nick end-labeling methods. Moreover, the expression level of caspase 3, activity of caspase 3, and serum level of tumor necrosis factor (TNF)-α of each group were also analyzed. Finally, quantitative real-time polymerase chain reaction and Western blotting analysis were carried out to detect angiopoietin-like 4 (ANGPTL4) expression level. Results: We found that mice infected with the FM1 strain of H1N1 influenza A virus developed severe ALI, and MST could improve H1N1-induced ALI. Moreover, MST decreased lung cell apoptosis and reduced the serum content of TNF-α. In addition, MST significantly induced the ANGPTL4 expression in H1N1-induced ALI. Conclusion: MST improves H1N1-associated ALI maybe through targeting ANGPTL4 in mice.

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Role of Angptl4 in vascular permeability and inflammation

Cited by 93 publications

References 50 publications

Angiopoietin-like protein 4 significantly predicts future cardiovascular events in coronary patients

Angiopoietin-like protein 4 significantly predicts future cardiovascular events in coronary patients

Gene expression changes in bioceramic paste-treated human dental pulp cells

Effect of Maxing Shigan Tang on H1N1 Influenza A Virus-Associated Acute Lung Injury in Mice

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