Role of altered coagulation-fibrinolytic system in the pathophysiology of diabetic retinopathy

Behl, Tapan; Velpandian, Thirumurthy; Kotwani, Anita

doi:10.1016/j.vph.2017.03.005

Cited by 18 publications

(14 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Further, chronic hyperglycemia promotes glycation of the proteins involved in fibrinolysis and affects clot structure, increasing its resistance to degradation by plasmin. 22,23) Moreover, hyperglycemia activates the metabolic pathways of polyol and protein kinase C, which increases oxidative stress. All these processes cause vascular damage that affects the hemostatic system.…”

Section: Discussionmentioning

confidence: 99%

“…Several mechanisms contribute to the prothrombotic state in these patients, including endothelial dysfunction, hypercoagulability, and hypofibrinolysis. Further, chronic hyperglycemia promotes glycation of the proteins involved in fibrinolysis and affects clot structure, increasing its resistance to degradation by plasmin [ 22 , 23 ]. Moreover, hyperglycemia activates the metabolic pathways of polyol and protein kinase C, which increases oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hemostatic state of children with type 1 diabetes

Alemán

Díaz

Luciardi

et al. 2021

Ann Pediatr Endocrinol Metab

View full text Add to dashboard Cite

Hyperglycemia is one of the factors responsible for the molecular alterations that modify hemostasis. The aim of this study was to determine the levels of circulating molecules that have a prothrombotic impact on the child and adolescent population with type 1 diabetes mellitus. Methods: There were 35 patients with type 1 diabetes mellitus (11.0±2.5 years of age and a median 3.7±2.0 years of the disease) with no vascular complications and 20 healthy controls with similar age, sex, and body mass index included in the study. The evaluated parameters were fibrinogen, plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor antigen, and standard coagulation tests (platelet count, prothrombin time, and activated partial thromboplastin time). Glycemic control was evaluated by hemoglobin A1c and fasting blood glucose tests, and the presence of retinopathy and nephropathy was ruled out. The data obtained were analyzed by IBM SPSS Statistics ver. 20.0 and expressed as mean±standard deviation. The Pearson correlation coefficient was applied to investigate correlations between variables. Results: Diabetic patients showed significantly higher levels of fibrinogen (308±66 mg/dL vs. 246±18 mg/dL, P=0.0001), PAI-1 (41.6±12 ng/mL vs. 11.7±1.0 ng/ mL, P=0.0001), and von Willebrand factor antigen (284%±55% vs. 121%±19%, P=0.0001). However, standard coagulation tests did not show differences between the 2 groups. PAI-1 was correlated with glycemia, hemoglobin A1c, fibrinogen, and von Willebrand factor antigen. Conclusion: Elevated levels of fibrinogen, PAI-1, and von Willebrand factor antigen were found in the pediatric and adolescent population with type 1 diabetes mellitus, which suggests a prothrombotic state.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hemostatic state of children with type 1 diabetes

Alemán

Díaz

Luciardi

et al. 2021

Ann Pediatr Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…Varios mecanismos contribuyen al estado protrombótico, incluidos disfunción endotelial, hipercoagulabilidad e hipofibrinólisis. Además la hiperglucemia crónica conduce a la glicación de las proteínas involucradas en la fibrinólisis al afectar la estructura fisiológica del coágulo y hacerlo más resistente a la degradación por la plasmina 22,23 . También la hiperglucemia activa la vía metabólica del poliol y la proteinquinasa C, y aumenta el estrés oxidativo.…”

Section: Discussionunclassified

Moléculas Protrombóticas en Niños Con Diabetes Mellitus Tipo 1

Abregú

Díaz

M³

et al. 2019

Rev. Soc. Argent. Diabetes

View full text Add to dashboard Cite

Introducción: la hiperglucemia contribuye a cambios moleculares que alteran la hemostasia.Objetivos: determinar moléculas circulantes que indiquen la presencia de un estado protrombótico en una población infanto juvenil con diabetes mellitus tipo 1 (DM1), sin manifestación clínica de enfermedad vascular, y compararla con una población control.Pacientes y métodos: se estudiaron 35 pacientes con DM1, de 11,0±2,5 años de edad y 3,7±2,0 años de evolución de la enfermedad, sin complicaciones vasculares y 20 controles sanos de edad, sexo e IMC semejantes. Se determinaron: fibrinógeno (Fg), inhibidor del activador del plasminógeno 1 (PAI-1), antígeno del factor von Willebrand (FvW:Ag), ligando CD40 soluble (sCD40L) y pruebas globales de coagulación como recuento de plaquetas, tiempo de protrombina (TP) y tiempo de tromboplastina parcial activado (APTT). El control glucémico se evaluó mediante glucemia en ayunas y A1c, y se descartó la presencia de retinopatía y nefropatía.

show abstract

“…The role of PS components is crucial in the development of inflammatory process, in particular peritonitis [8,9]. At the same time, the changes of PS activity are an integral part of DM development mechanisms [10][11][12]. Therefore, the study of PS reactions in acute peritonitis against the background of diabetes mellitus appears to be rather topical.…”

Section: Introductionmentioning

confidence: 99%