Role of age and sex in determining antibiotic resistance in febrile urinary tract infections

Lee, Dong Sup; Choe, Hyun‐Sop; Kim, Hee Youn; Yoo, Je Mo; Bae, Woong Jin; Cho, Yong Hyun; Kim, Sun Wook; Han, Chang Hee; Bae, Sang Rak; Jang, Han Ik; Park, Su Bum; Yoon, Byung Il; Lee, Seung-ju

doi:10.1016/j.ijid.2016.08.015

Cited by 29 publications

(24 citation statements)

References 23 publications

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“…Antibacterial resistance micro-organisms limit and complicate treatment which is difficult to overcome due to multidrug resistant properties. The outcome of this study showed a high prevalence of Escherichia coli from several sources of clinical samples associated with multiple resistance genes.In a previous investigation, sex-dependent antibiotic resistance was established (Ben-Ami et al, 2009) while in a recent study, age was not a substantial issue in defining the antibiotic resistance but gender plays a vital role in the sensitivity (Lee et al, 2016). This study revealed that no antibiotic resistance significant variance in between the males and females (P >.05) which is also in agreement with a previous study by Ghadiri (Ghadiri et al, 2014).…”

Section: Discussionsupporting

confidence: 91%

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Detection of Metallo-?-Lactamasesencoding Genes Among Clinical Isolates of Escherichia Coli in a Tertiary Care Hospital, Malaysia

Fazlul¹,

Najnin²,

Yasmin³

et al. 2019

IJPR

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The multidrug resistant Escherichia coli strains causes multiple clinical infections and has become a rising problem globally. The metallo-β-lactamases encoding genes are very severe in gram-negative bacteria especially E. coli. This study was aimed to evaluate the prevalence of MBLs among the clinical isolates of E. coli. A total of 65 E. coli isolates were collected from various clinical samples of Malaysian patients with bacterial infections. The conventional microbiological test was performed for isolation and identification of E. coli producing MBLs strains in this vicinity. Multidrug Resistance (MDR) of E. coli isolates were assessed using disk diffusion test. Phenotypic methods, as well as genotypic-PCR methods, were performed to detect the presence of metallo-β-lactamase resistance genes (blaIMP, blaVIM) in imipenem resistant strains. Out of 65 E. coli isolates, 42 isolates (57.3%) were MDR. The isolates from urine (19) produced significantly more MDR (10) isolates than other sources. Additionally, 19 (29.2%) imipenemresistant E. coli isolates contained 10 MBLs gene, 7(36.8%) isolates contained blaIMP and 3(15.7%) isolates contained blaVIM genes. This study revealed the significant occurrence of MBL producing E. coli isolates in clinical specimens and its association with health risk factors indicating an alarming situation in Malaysia. It demands an appropriate concern to avoid failure of treatments and infection control management.

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Section: Discussionsupporting

confidence: 91%

“…and most (47.7%) resistant gene was isolated from pus swabs(Okoche et al, 2015). More than 80% of the urinary tract infections (UTI) while female febrile UTIs 86.3% and male febrile UTIs 78.5% are due to E. coli(Lee et al, 2016). Misappropriation of antibiotic is liable for the higher incidence of antibiotic resistance among bacteria(Neupane et al, 2016).…”

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confidence: 99%

Detection of Metallo-?-Lactamasesencoding Genes Among Clinical Isolates of Escherichia Coli in a Tertiary Care Hospital, Malaysia

Fazlul¹,

Najnin²,

Yasmin³

et al. 2019

IJPR

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“…Unfortunately, in our analysis, SA strains isolated from older patients demonstrated significantly increased TMP/SXT resistance, limiting its usefulness in the treatment of patients aged ≥75 years. Lee et al showed strains isolated from patients with febrile urinary tract infections demonstrating very high resistance to TMP/SXT, no metter how old the patients were [ 23 ]. According to a study by Leistevuo et al, TMP/SXT (or trimethoprim alone) was most frequently prescribed antimicrobial medicine to aged ≥85 years females with urinary tract infections (37%) [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Longevity and gender as the risk factors of methicillin-resistant Staphylococcus aureus infections in southern Poland

Pomorska-Wesołowska¹,

Różańska

Natkaniec

et al. 2017

BMC Geriatr

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BackgroundThe proportion of older people among the general population has risen. Staphylococcus aureus (SA) constitutes a significant problem. Underlying disease and functional debility, predispose the older adult to staphylococcal carriage and infection, specially bloodstream infection and pneumonia.MethodsThis is a retrospective cohort study of older patients with SA infections. We analyzed a database containing the results of laboratory cultures from patients treated in 2013 for SA infections and selected 613 hospitalized and non-hospitalized people aged ≥60 years.ResultsThe prevalence of Methicillin-resistant SA (MRSA) were significantly different in categories of patients: from 14.1% in young old, 19.5% in old old and 26.7 in longevity. MRSA was significantly more frequently reported in cases of pneumonia, 40.4% of SA strains (p < 0.0001, OR 0.3, 95%CI 0.14–0.49). The nosocomial MRSA infections were more common in ICU departments: prevalence 36.8%, than in non-ICU departments: prevalence 17.3% (OR 2.8, 95%CI 1.06–7.34, p = 0.014). Bloodstream infections, which accounted for 6% of all infections, were more frequent in males (p = 0.0231, OR 2.25, 95%CI 1.098–4.604). The greatest increase in antibiotic resistance was related to trimethoprim/sulfamethoxazole (TMP/SXT), which increased to over 80% in the older study groups. All age groups demonstrated increased MIC90 values for glycopeptide and tigecycline. Although strains isolated from patients in all age groups remained sensitive to vancomycin, strains isolated from patients in the old-old and longevity groups demonstrated resistance to teicoplanin. The MIC90 for tigecycline was the highest in the group aged >90 years.ConclusionsMRSA constitutes a significant epidemiological problem in cases of hospital-treated pneumonia. The findings were similar for long-term-care facilities, where MRSA appears to affect male residents in particular, although there were fewer male residents than female residents. The low sensitivity to TMP/SXT of SA strains isolated from the oldest patients indicates potentially serious challenges pertaining to efficacious treatment of SA infections.

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“…According to Lee et al, the susceptibility of gram-negative bacteria to ciprofloxacin was much higher in patients less than 20 years old than in patients more than 20 years old. The reason for this observation may be the lower exposure to fluoroquinolones in young individuals because these drugs are not recommended for use in those under 20 years old [ 17 ].…”

Section: Antimicrobial Susceptibility Pattern Of E Colimentioning

confidence: 99%

“…Catheter-associated UTIs have multiple confounding factors associated with emerging antimicrobial resistance, that is, hospital factors due to frequent hospitalization, foreign body bridges between the urinary bladder and the outside of the body, and frequent antibiotic exposure. A previous study conducted with outpatient UTIs showed that catheter-associated UTIs were more closely associated to exposure to antibiotics and exhibited a higher occurrence of infection caused by an atypical organism, such as Citrobacter species, Proteus mirabilis , Morganella morganii , Enterobacter species , and Pseudomonas aeruginosa rather than E. coli [ 17 ]. Those atypical organisms can harbor MDR determinant and can transfer the resistance determinants (e.g., AmpC gene) to E. coli (see Section 5 ).…”

Section: Complicated Utis and Mdr Gram-negative Bacteriamentioning

confidence: 99%

Community-Acquired Urinary Tract Infection byEscherichia coliin the Era of Antibiotic Resistance

Lee

Choe

2018

BioMed Research International

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154

106

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Urinary tract infections (UTIs) caused by Escherichia coli (E. coli) are the most common types of infections in women. The antibiotic resistance of E. coli is increasing rapidly, causing physicians to hesitate when selecting oral antibiotics. In this review, our objective is to ensure that clinicians understand the current seriousness of antibiotic-resistant E. coli, the mechanisms by which resistance is selected for, and methods that can be used to prevent antibiotic resistance.

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Role of age and sex in determining antibiotic resistance in febrile urinary tract infections

Cited by 29 publications

References 23 publications

Detection of Metallo-?-Lactamasesencoding Genes Among Clinical Isolates of Escherichia Coli in a Tertiary Care Hospital, Malaysia

Detection of Metallo-?-Lactamasesencoding Genes Among Clinical Isolates of Escherichia Coli in a Tertiary Care Hospital, Malaysia

Longevity and gender as the risk factors of methicillin-resistant Staphylococcus aureus infections in southern Poland

Community-Acquired Urinary Tract Infection byEscherichia coliin the Era of Antibiotic Resistance

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