Role of advanced glycation end products in the onset of diabetic kidney disease complications

Paula, Maria Luiza Almeida de; Villela, Ana Marina Rodrigues; Negri, M; Kanaan, Salim; Weide, Luciene de Carvalho Cardoso

doi:10.4322/2357-9730.74457

Cited by 3 publications

(3 citation statements)

References 57 publications

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“…Образование КПГ Острая гипергликемия, гиперкетонемия и повышение продукции АФК на фоне ДКА инициируют неферментативное гликирование аминокислот с образованием токсичных α-дикарбонилов и, в последующем -гетерогенной группы КПГ [29,47,48]. КПГ модифицируют внутриклеточные белки, в том числе участвующие в регуляции транскрипции генов [49]. В белках в первую очередь гликированию подвергаются остатки аргинина и лизина, и одним из наиболее распространенных КПГ является N(6)-карбоксиметиллизин [47].…”

Section: основные патофизиологические механизмыunclassified

Diabetic ketoacidosis and oxidative stress: pathophysiological mechanisms

Bykov

2024

Sibirskij nauchnyj medicinskij zhurnal

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Diabetes mellitus (DM) is a common endocrine disease with a large number of acute and chronic complications, among which diabetic ketoacidosis (DKA) is the most frequent and severe, especially in children and adolescents with type 1 DM. Oxidative stress (OS) is a pathological condition that develops due to an imbalance between free radicals formation and inefficiency of the antioxidant system. OS is a strong risk factor for the development of numerous diabetic complications. Recently OS has been considered as an important component of DKA, the pathophysiological mechanisms of which have not yet been fully elucidated. This paper describes hypotheses according to which OS not only triggers and exacerbates manifestations of DKA, but itself represents a severe consequence of DKA, leading to the progression of numerous micro- and macroscopic diabetic complications. The formation of glycation end products, activation of protein kinase C, polyol and hexosamine pathways are considered among the key pathophysiologic mechanisms of OS development in DKA. Achieving a better understanding of OS pathogenesis in DKA will optimize the diagnosis of OS and approaches to DKA correction through timely prescription of antioxidants.

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Section: основные патофизиологические механизмыunclassified

Diabetic ketoacidosis and oxidative stress: pathophysiological mechanisms

Bykov

2024

Sibirskij nauchnyj medicinskij zhurnal

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“…Subsequent research has suggested that AGEs also degrade pancreatic β-cells, thus contributing to their impaired function or apoptosis. Studies by Lim et al [ 35 ] showed that AGEs treatment induces ROS formation and RAGE expression, as well as causing β-cells apoptosis. Antioxidant treatment and RAGE inhibition prevented these changes, suggesting that AGEs stimulate cell death through RAGE-induced ROS generation.…”

Section: Oxidative Stress and Diabetesmentioning

confidence: 99%

MicroRNAs and Oxidative Stress: An Intriguing Crosstalk to Be Exploited in the Management of Type 2 Diabetes

et al. 2021

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Type 2 diabetes is a chronic disease widespread throughout the world, with significant human, social, and economic costs. Its multifactorial etiology leads to persistent hyperglycemia, impaired carbohydrate and fat metabolism, chronic inflammation, and defects in insulin secretion or insulin action, or both. Emerging evidence reveals that oxidative stress has a critical role in the development of type 2 diabetes. Overproduction of reactive oxygen species can promote an imbalance between the production and neutralization of antioxidant defence systems, thus favoring lipid accumulation, cellular stress, and the activation of cytosolic signaling pathways, and inducing β-cell dysfunction, insulin resistance, and tissue inflammation. Over the last few years, microRNAs (miRNAs) have attracted growing attention as important mediators of diverse aspects of oxidative stress. These small endogenous non-coding RNAs of 19–24 nucleotides act as negative regulators of gene expression, including the modulation of redox signaling pathways. The present review aims to provide an overview of the current knowledge concerning the molecular crosstalk that takes place between oxidative stress and microRNAs in the physiopathology of type 2 diabetes, with a special emphasis on its potential as a therapeutic target.

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“…Numerous research findings have clearly shown that these diseases and complications have a promising link with the glycated proteins and Advanced Glycation End Products (AGEs), which are formed through the protein glycation reaction under hyperglycaemic conditions in diabetes patients [ 7 ]. However, protein glycation is not a simple reaction and is defined as a series of complex non-enzymatic reactions between proteins and sugars giving rise to a multitude of heterogeneous glycated end products which are widely known as the AGEs [ 9 , 10 ]. Glycation reaction is broadly categorized into 3 stages as early-, middle-, and late-stage glycation [ 7 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Antiamylase, Antiglucosidase, and Antiglycation Properties of Millets and Sorghum from Sri Lanka

Senevirathne

Abeysekera

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The present study evaluated a range of biological activities of selected millet types and sorghum varieties in Sri Lanka in relation to diabetes and its complications management. Five millet types, namely, proso millet, white finger millet, kodo millet, foxtail millet, and finger millet (Oshadha and Rawana), and two sorghum varieties, namely, sweet sorghum and sorghum ICSV 112, were used in this study. Methanolic extracts of whole grains were studied for antiamylase, antiglucosidase, and early- and middle-stage antiglycation and glycation reversing activities in vitro. Tested millets and sorghum showed significant ( p < 0.05) and dose-dependent antiamylase (IC50: 33.34 ± 1.11–1446.70 ± 54.10 μg/ml), early-stage antiglycation (IC50: 15.42 ± 0.50–270.03 ± 16.29 μg/ml), middle-stage antiglycation (135.08 ± 12.95–614.54 ± 6.99 μg/ml), early-stage glycation reversing (EC50: 91.82 ± 6.56–783.20 ± 61.70 μg/ml), and middle-stage glycation reversing (393.24 ± 8.68–1374.60 ± 129.30 μg/ml) activities. However, none of the studied millet and sorghum showed antiglucosidase activity. Out of the samples studied, pigmented samples, namely, sweet sorghum, Oshadha, and Rawana, exhibited significantly high ( p < 0.05) antiamylase and early- and middle-stage antiglycation and glycation reversing activities compared to other millet and sorghum samples. Interestingly, sweet sorghum exhibited nearly four times potent antiamylase activity compared to the standard drug acarbose (IC50 111.98 ± 2.68 μg/ml) and sweet sorghum, kodo millet, Oshadha, and Rawana showed comparable early-stage antiglycation activities in comparison to the reference standard Rutin (IC50 21.88 ± 0.16 μg/ml). Therefore, consumption of whole grains of pigmented millet and sorghum in Sri Lanka may play an important role in the prevention and management of diabetes and its complications. Interestingly, this is the 1st study to report all the tested biological activities for millet and sorghum in Sri Lanka and the 1st study to report both early- and middle-stage glycation reversing activities of millet and sorghum worldwide.

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Role of advanced glycation end products in the onset of diabetic kidney disease complications

Cited by 3 publications

References 57 publications

Diabetic ketoacidosis and oxidative stress: pathophysiological mechanisms

Diabetic ketoacidosis and oxidative stress: pathophysiological mechanisms

MicroRNAs and Oxidative Stress: An Intriguing Crosstalk to Be Exploited in the Management of Type 2 Diabetes

Antiamylase, Antiglucosidase, and Antiglycation Properties of Millets and Sorghum from Sri Lanka

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