Role of adjunct use of omega 3 fatty acids in periodontal therapy of periodontitis. A systematic review and meta-analysis

Changes in serum omega fatty acids on a Mediterranean diet intervention in patients with gingivitis: An exploratory study

“…Both diet counselling and supplementation were recommended in the conclusions. 14,48 The omega-6/omega-3 ratio achieved in the MedD group at T2 (median 8.71:1) was still significantly above the recommended values of a maximum of 4:1 or lower. 49 This could be due to both the constant omega-3 levels and the short observation period.…”

“…They concluded that there is a beneficial effect of omega‐3 PUFA supplementation in combination with periodontal treatment. Both diet counselling and supplementation were recommended in the conclusions 14,48 …”

“…After allocation by minimization using the sex (male/female) and age group (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49) characteristics of each patient, the participants kept their habitual diet for the first 2 weeks, accompanied by stopping all interdental cleaning activities and the use of mouthwashes to equilibrate the dental plaque values, comparable to the Woelber et al 8,9 These reduced dental cleaning conditions had to be maintained until the end of the study. Before participants in the MedDG began to change their diet toward the MedD, they received MedD training sessions of 90 min each in groups of up to five so that they could start the observation period as well prepared as possible.…”

The Effect of the Destruction of the Collagen Matrix on the Condition of Periodontal Tissues in Experimental Periodontitis

“…Деструкция коллагеновых волокон осуществляется как за счет генерации нейтрофилами активных форм кислорода, так и за счет фагоцитоза фибробластами с последующим разрушением лизосомальными ферментами коллагеновых структур путем расщепления пептидных связей в определенных участках спирализованных областей коллагена [7]. При прогрессировании воспаления деструктивные процессы происходят как в латеральном, так и в апикальном направлениях относительно области расположения очага воспаления, что сопровождается разрыхлением соединительнотканного матрикса и образованием пространства между зубом и эпителием десневой борозды -формированием десневого кармана [8]. Вследствие его последующего прорастания в подлежащую соединительную ткань, образования грануляций и последующего замещения ими костной ткани происходят формирование пародонтального кармана и разрушение опорных тканей зуба, что способствует возникновению патологической подвижности с последующей потерей зубов [9].…”

Impact of a Specific Collagen Peptide Food Supplement on Periodontal Inflammation in Aftercare Patients—A Randomised Controlled Trial

“…As the occurrence of disease-promoting bacterial dysbiosis is strongly promoted by an increased inflammatory status of the host, the use of adjuvant therapeutics that modulate inflammation at the local and/or systemic level is advocated to further improve the outcome of mechanical plaque control [ 11 , 12 ]. This may involve the systemic or local administration of drugs that either inhibit the inflammatory response or actively promote its resolution [ 13 ], as well as targeted changes in the daily diet of patients [ 14 , 15 , 16 , 17 , 18 ] or the consumption of food supplements such as probiotics or omega-3 fatty acids [ 19 , 20 , 21 , 22 ]).…”