Impact of a Specific Collagen Peptide Food Supplement on Periodontal Inflammation in Aftercare Patients—A Randomised Controlled Trial

Abstract

This controlled clinical trial evaluated the impact of a specific collagen peptide food supplement on parameters of periodontal inflammation in aftercare patients. Methods: A total of 39 study patients were enrolled. At baseline, bleeding on probing (BoP; primary outcome), gingival index (GI), plaque control record (PCR), recession (REC) and probing pocket depth (PPD) for the calculation of the periodontal inflamed surface area (PISA) were documented. After subsequent professional mechanical plaque removal (PMPR), participants were randomly provided with a supply of sachets containing either a specific collagen peptide preparation (test group; n = 20) or a placebo (placebo group; n = 19) to be consumed dissolved in liquid once daily until reevaluation at day 90. Results: PMPR supplemented with the consumption of the specific collagen peptides resulted in a significantly lower mean percentage of persisting BoP-positive sites than PMPR plus placebo (test: 10.4% baseline vs. 3.0% reevaluation; placebo: 14.2% baseline vs. 9.4% reevaluation; effect size: 0.86). Mean PISA and GI values were also reduced compared to baseline, with a significant difference in favor of the test group (PISA test: 170.6. mm2 baseline vs. 53.7 mm2 reevaluation; PISA placebo: 229.4 mm2 baseline vs. 184.3 mm2 reevaluation; GI test: 0.5 baseline vs. 0.1 reevaluation; GI placebo: 0.4 baseline vs. 0.3 reevaluation). PCR was also significantly decreased in both experimental groups at revaluation, but the difference between the groups did not reach the level of significance. Conclusions: The supplementary intake of specific collagen peptides may further enhance the anti-inflammatory effect of PMPR in periodontal recall patients.

Anti-Inflammatory Benefits of Food Ingredients in Periodontal Diseases

“…Periodontal recall patients with a history of treated periodontitis who received collagen peptides after professional mechanical debridement showed significantly lower gingival bleeding and periodontal inflamed surface area (PISA) compared to patients who received professional mechanical debridement and placebo, decreasing the risk of re-activation of periodontitis [40]. The adjunctive intake of a nutraceutical agent containing baicalin (Neuridase ® , Enfarma SRL, Misterbianco, Italy) with SRP in patients with moderate periodontitis significantly decreased PPD and BoP but also pain after SRP, compared to SRP and placebo [41]. More studies on nutraceutical agents and other micronutrient supplements are needed to better evaluate their adjunctive effect on periodontal therapy.…”

The Potential of Collagen Treatment for Comorbid Diseases

“…In periodontal recall patients, the additional consumption of targeted collagen peptides has the potential to further augment the anti-inflammatory impact of professional mechanical plaque removal [79]. A rat study suggested that the whey component of milk protein promoted bone collagen synthesis, improved bone strength, and prevented alveolar bone loss by elevating hydroxyproline levels, thereby enhancing bone integrity [80,81].…”