Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats

The central amygdala regulates sodium intake in sodium-depleted rats: Role of 5-HT3 and 5-HT2C receptors

“…Fig. 7 shows a comparison between the effect of m-CPBG in several doses when injected into the CeA (produced in the present paper) with the effect of the injection of m-CPBG at the same doses when injected into the MeA, as we have presented in a previous paper (Luz et al, 2006). It is clear that, at the same doses, m-CPBG elicits a more powerful inhibition of salt intake in sodium-depleted rats when injected into the CeA as compared to the effect produced by the same drug when injected into the MeA.…”

“…The CeA is located dorsomedially in the rostral part of the amygdala having the basolateral complex as lateral (one-way ANOVA followed by Newman-Keul's test; p < 0.05) when the distinct groups of animals receiving injections of m-CPBG into the CeA are compared to animals receiving injections of m-CPBG at the same doses into the MeA. The data on m-CPBG effects on salt intake when injected into MeA were produced in a previous paper (Luz et al, 2006).…”

“…We have recently demonstrated that both 5-HT 3 and 5-HT 2C receptors in the amygdala influence sodium appetite since the pharmacological activation of 5-HT 3 receptors located within the MeA inhibits salt intake and, in this brain region, the functional integrity of 5-HT 2C receptors is required for the full expression of sodium appetite when rats are sodium-depleted (Luz et al, 2006).…”

5‐HT2C antagonism blocks blood oxygen level‐dependent pharmacological‐challenge magnetic resonance imaging signal in rat brain areas related to feeding

“…, 1998). Serotonin is also implicated, as 5‐HT 2C receptors in the amygdala are demonstrated to be important in mediating the expression of salt appetite in rats that are sodium depleted (Luz et al. , 2006).…”

“…More recently, alterations in feeding are reported to result from amygdala injections of peptides such as enterostatin (Lin & York, 2005), melanocortin 4 receptor antagonists (Kask & Schioth, 2000) or agonists at opioid receptors (Giraudo et al, 1998). Serotonin is also implicated, as 5-HT 2C receptors in the amygdala are demonstrated to be important in mediating the expression of salt appetite in rats that are sodium depleted (Luz et al, 2006). The fact that the amygdala shares extensive interactions with the hypothalamus and brainstem (for review see Sah et al, 2003) supports our imaging data that show blockade of mCPP-induced activity by SB 242084 in each of these regions.…”