Role of 5‐HT<sub>1A</sub> Receptors in Acquisition, Consolidation and Retrieval of Learning

Meneses, Alfredo; Hong, Enrique

doi:10.1111/j.1527-3458.1997.tb00317.x

Cited by 20 publications

(16 citation statements)

References 95 publications

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“…In behavioral learning paradigms, 5-HT 1A receptors have been the most extensively studied (Table 2). Even though current available evidence is inconsistent (see Harvey, 1996;Meneses and Hong, 1997 for earlier reviews), some clear findings have emerged. From a methodological point of view, investigators have administered 5-HT 1A drugs either before or after the learning task and/or the pre-RET phase, with pre-training administration the most frequently used ( Table 2).…”

Section: -Ht 1a Receptors: Behavioral Learning and Memory Tasksmentioning

confidence: 93%

“…From a methodological point of view, investigators have administered 5-HT 1A drugs either before or after the learning task and/or the pre-RET phase, with pre-training administration the most frequently used ( Table 2). Each of these drug administration protocols allows the study of different stages or phases of memory: acquisition (ACQ), CON, and/or retrieval (McGaugh, 1989;Meneses, 1999Meneses, , 2003Meneses and Hong, 1997). The effects induced by pre-training injections might affect ACQ and/or reflect nonspecific changes (i.e., motivation, perception, motor activity), whereas those behavioral and/or neurobiological changes produced by post-training injections may be attributed to memory-related mechanisms since the information has already been acquired and stored in memory.…”

Section: -Ht 1a Receptors: Behavioral Learning and Memory Tasksmentioning

confidence: 99%

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5-HT1A receptors and memory

Meneses

Pérez-García

2007

Neuroscience & Biobehavioral Reviews

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114

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Section: -Ht 1a Receptors: Behavioral Learning and Memory Tasksmentioning

confidence: 93%

Section: -Ht 1a Receptors: Behavioral Learning and Memory Tasksmentioning

confidence: 99%

5-HT1A receptors and memory

Meneses

Pérez-García

2007

Neuroscience & Biobehavioral Reviews

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114

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“…Groups of male SHR and their respective control WKY of several ages (3,6,9,12,18, and 24 months old) were used. Groups of each age and strain were housed separately in a temperature-and light-controlled room under a 12-hour light/dark cycle, with water and food provided ad libitum.…”

Section: Animalsmentioning

confidence: 99%

“…18,22,25,28,32 Therefore, the use of the autoshaping test as a nonthreatening behavioral task is completely justified. 2,3,5,7,9,11,41 …”

Section: Cognitive Deficits Induced By Hypertension and Agingmentioning

confidence: 99%

Spontaneously Hypertensive Rats

Meneses

Hong

1998

Hypertension

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Abstract-Spontaneously hypertensive rats (SHR) of 3 to 12 months of age learned and retrieved less information than normotensive Wistar-Kyoto rats (WKY), although no difference was found with animals from 18 and 24 months of age. The combined influence of hypertension and aging had an additive detrimental effect on cognitive functions. Notwithstanding these deficiencies in learning and memory, SHR have seldom been used as a model in the screening of drugs with therapeutic potential for treatment of disorders of cognitive processes. Moreover, the calcium channel blocker nimodipine has beneficial effects on learning in both aged and hypertensive animals and humans. However, no attempt has been made to investigate whether nimodipine can reverse the additive deleterious effects of aging and hypertension in the same subject. We recently reported that deteriorated animals (middle-aged and/or hypertensive) chronically treated with nimodipine (via osmotic minipumps) exhibit higher learning scores. This information indicates that nimodipine can reverse the impairing effects of either aging or hypertension on learning; the presence of the two conditions, however, produces a severe impairment that can be partially reversed by this drug. Therefore, we propose that mature and middle-aged SHR represent a model for the screening of potentially useful drugs in the treatment of learning disorders, probably associated with hypertension and/or aging. Nevertheless, it must be remembered that the SHR is a genetic model and the appearance of neural disturbances could be a parallel genetic phenomenon and not necessarily or exclusively related to hypertension per se. (Hypertension. 1998;31:968-972.)Key Words: rats, inbred SHR Ⅲ learning Ⅲ memory Ⅲ aging Ⅲ pharmacology Ⅲ models A great expansion of experimental research began with the development of rat strains with genetically inherited hypertension. The SHR offers specific and uniform genetic predisposition, 1 thus allowing the study of the causes, mechanisms, and pathology of hypertension, as well as its behavioral consequences, and the comparison of the efficacy of proposed therapeutic interventions in relation to existing clinical treatments. Moreover, central neurohormonal mechanisms constitute the dominating trigger influence in SHR 1 and provide a model of hypertension that allows the study of the combined influence of both aging and hypertension on cognitive and physical functions on different developmental stages.2,3 Notwithstanding, the SHR is a genetic model, and the appearance of neural disturbances could be a parallel genetic phenomenon and not necessarily or exclusively related to the elevated blood pressure per se. Normal aging also produces a slow decline in neuron population, tissue distensibility, basal metabolic rate, and oxygen consumption, thus affecting cardiovascular performance. The aim of the present work was to present evidence obtained in our laboratory supporting the idea that the SHR is a suitable behavioral model to test drugs with potential therapeutic us...

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“…Cells expressing 5-HT 3 receptor mRNA were found scattered throughout the major subdivisions of the amygdala (Tecott et al, 1993). There is evidence suggesting that 5-HT and its receptors might have a role in processes of learning and memory, including 5-HT 1A , 5-HT 2A/2C , and 5-HT 3 receptors (Meneses and Hong, 1997). As a first step towards elucidating the functional roles of different serotonin receptors within the amygdala, we used the techniques of extracellular single cell recording and microiontophoresis and studied the effects of 5-HT and of 5-HT agonists for 5-HT 1A , 5-HT 2A/2C , and 5-HT 3 receptors on neuronal activity recorded in different subnuclei of the amygdala in urethane-anesthetized rats.…”

Section: Introductionmentioning

confidence: 99%

5-HT1A receptor-mediated inhibition and 5-HT2 as well as 5-HT3 receptor-mediated excitation in different subdivisions of the rat amygdala

Stein

Davidowa

Albrecht

2000

Synapse

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The techniques of extracellular single cell recording and microiontophoresis were used to study the effects of serotonin (5‐HT) and of 5‐HT1A, 5‐HT2A/2C and 5‐HT3 receptor agonists on the spontaneous activity of amygdaloid neurons in rats anesthetized with urethane. The background discharge rate was modified by 5‐HT as well as by 5‐HT agonists in about two‐thirds of neurons tested in different nuclei of the amygdaloid complex. Whereas the 5‐HT2 and 5‐HT3 agonists significantly increased the neuronal discharge rate in nearly all subdivisions of the amygdala, the 5‐HT1A agonist significantly inhibited the firing rate. Co‐administration of bicuculline and 5‐HT receptor agonists prevented the 8‐OH‐DPAT‐induced increases in the firing rate in most cases tested, as well as the inhibitory effects of DOI or 2‐methyl‐5HT. Therefore, GABAergic interneurons seem to be involved in the mediation of serotonergic effects. The action of 5‐HT agonists on the neuronal discharge rate was blocked by different receptor‐specific antagonists. The results support the hypothesis that 5‐HT exerts control throughout the amygdala by acting at least on 5‐HT1A, 5‐HT2A/2C and 5‐HT3 receptors seemingly located both on projection and interneurons. Synapse 38:328–337, 2000. © 2000 Wiley‐Liss, Inc.

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Role of 5‐HT_1A Receptors in Acquisition, Consolidation and Retrieval of Learning

Cited by 20 publications

References 95 publications

5-HT1A receptors and memory

5-HT1A receptors and memory

Spontaneously Hypertensive Rats

5-HT1A receptor-mediated inhibition and 5-HT2 as well as 5-HT3 receptor-mediated excitation in different subdivisions of the rat amygdala

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Role of 5‐HT1A Receptors in Acquisition, Consolidation and Retrieval of Learning

Cited by 20 publications

References 95 publications

5-HT1A receptors and memory

5-HT1A receptors and memory

Spontaneously Hypertensive Rats

5-HT1A receptor-mediated inhibition and 5-HT2 as well as 5-HT3 receptor-mediated excitation in different subdivisions of the rat amygdala

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Product

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Role of 5‐HT_1A Receptors in Acquisition, Consolidation and Retrieval of Learning