5-HT1A receptors and memory

Meneses, Alfredo; Pérez-García, Georgina

doi:10.1016/j.neubiorev.2007.02.001

Cited by 114 publications

(63 citation statements)

References 157 publications

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“…It is well known that the 5-HT 1A receptor subtype interacts with several neurotransmitter systems. [15][16][17] Buspirone has been reported to increase dopamine (DA) levels in regions considered essential for cognitive processing such as the prefrontal cortex and hippocampus. 15,48 In addition, numerous studies have shown that DA neurotransmission is important for spatial learning and memory (for excellent reviews, see [10][11][12][13] ).…”

Section: Discussionmentioning

confidence: 99%

“…[15][16][17] Several studies have shown that systemic administration of early-and-single (i.e., acute) as well as delayed-and-multiple (i.e., chronic) treatments with the 5-HT 1A receptor agonists repinotan HCL and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) confer neurobehavioral benefits after TBI. [18][19][20][21][22][23][24] More recently, buspirone, also a 5-HT 1A receptor agonist, has been reported to enhance cognitive performance as well as significantly reduce cortical lesion volume after TBI.…”

Section: Introductionmentioning

confidence: 99%

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A Combined Therapeutic Regimen of Buspirone and Environmental Enrichment Is More Efficacious than Either Alone in Enhancing Spatial Learning in Brain-Injured Pediatric Rats

Monaco

Gebhardt

Chlebowski

et al. 2014

Journal of Neurotrauma

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Buspirone, a 5-HT 1A receptor agonist, and environmental enrichment (EE) enhance cognition and reduce histopathology after traumatic brain injury (TBI) in adult rats, but have not been fully evaluated after pediatric TBI, which is the leading cause of death in children. Hence, the aims of this study were to assess the efficacy of buspirone alone (Experiment 1) and in combination with EE (Experiment 2) in TBI postnatal day-17 male rats. The hypothesis was that both therapies would confer cognitive and histological benefits when provided singly, but their combination would be more efficacious. Anesthetized rats received a cortical impact or sham injury and then were randomly assigned to receive intraperitoneal injections of buspirone (0.08 mg/kg, 0.1 mg/kg, and 0.3 mg/kg) or saline vehicle (1.0 mL/kg) 24 h after surgery and once daily for 16 days (Experiment 1). Spatial learning and memory were assessed using the Morris water maze (MWM) on post-operative days 11-16, and cortical lesion volume was quantified on day 17. Sham controls for each condition were significantly better than all TBI groups. In the TBI groups, buspirone (0.1 mg/kg) enhanced MWM performance versus vehicle and buspirone (0.08 mg/kg and 0.3 mg/kg) ( p < 0.05) and reduced lesion volume relative to vehicle ( p = 0.038). In Experiment 2, buspirone (0.1 mg/kg) or vehicle was combined with EE after TBI, and the data were compared to the standard (STD)-housed groups from Experiment 1. EE lead to a significant enhancement of spatial learning and a reduction in lesion size versus STD. Moreover, the combined treatment group (buspirone + EE) performed markedly better than the buspirone + STD and vehicle + EE groups, which suggests an additive effect and supports the hypothesis. The data replicate previous studies assessing these therapies in adult rats. These novel findings may have important rehabilitationrelevant implications for clinical pediatric TBI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Combined Therapeutic Regimen of Buspirone and Environmental Enrichment Is More Efficacious than Either Alone in Enhancing Spatial Learning in Brain-Injured Pediatric Rats

Monaco

Gebhardt

Chlebowski

et al. 2014

Journal of Neurotrauma

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“…This hypothesis is further supported by the finding that neonatally MDMA-treated animals had enhanced G-protein activity after 5-HTstimulation in the hippocampus and prefrontal cortex as adults, and an increase of G-protein activity after (+)-8-OH-DPAT stimulation in the hippocampus, suggesting an increase in sensitivity of the 5-HT 1A receptor (Crawford et al, 2006). The 5-HT 1A receptor has been implicated in learning and memory and is a possible mechanism for learning and memory deficits in MDMA-treated animals (Meneses and Perez-Garcia, 2007). In particular, increases in the 5-HT 1A receptor were observed in older rats that had deficits in the MWM (Topic et al, 2007).…”

Section: Biochemistrymentioning

confidence: 99%

Developmental effects of 3,4-methylenedioxymethamphetamine: a review

Skelton

Williams

Vorhees

2008

Behavioural Pharmacology

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Abstract± 3,4-Methylenedioxymethamphetamine (MDMA) is a chemical derivative of amphetamine that has become a popular drug of abuse and has been shown to deplete serotonin in the brains of users and animals exposed to it. To date, most studies have investigated the effects of MDMA on adult animals. With a majority of users of MDMA being young adults, the chances of the users becoming pregnant and exposing the fetuses to MDMA are also a concern. Evidence to date has shown that developmental exposure to MDMA results in learning and memory impairments in the Morris water maze, a task known to be sensitive to hippocampal disruption, when the animals are tested as adults. Developmental MDMA exposure leads to hypoactivity in the offspring as adults but does not affect outcome on tests of anxiety. MDMA administration decreases pup weight, increases corticosterone and brain-derived neurotrophic factor levels during treatment while decreasing brain levels of serotonin; a decrease that initially dissipates and then reappears in adulthood. Neonatal MDMA exposure increases the sensitivity of the serotonin 1A receptor, a possible mechanism underlying the learning and memory deficits seen. Taken together, the evidence shows that MDMA exposure has adverse effects on the developing brain and behavior. The animal and human data on developmental MDMA exposure are reviewed and their public health implications discussed.

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“…For example, glutamate has been involved jointly with DA in cognitive functioning as well (Kodama, Hikosaka, & Watanabe, 2002) and serotonin with memory and amnesia (cf. Meneses & Perez-Garcia, 2007).…”

Section: Influence Of Genetics and Neurotransmittersmentioning

confidence: 99%