Role of 18F-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohnʼs Disease

Russo, Evangelos; Khan, Sameer; Janisch, Ryan; Gunn, Roger N.; Rabiner, Eugenii A.; Taylor, Stuart A.; Matthews, Paul M.; Orchard, Timothy R.

doi:10.1097/mib.0000000000000924

Cited by 14 publications

(7 citation statements)

References 41 publications

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“…The strength of this prospective study was a well-documented reference standard. In addition, the present study included patients experiencing CU, CD, or intermediate colitis, whereas previous studies using PET/MRI focused on assessment of malignancies and non-specified inflammatory state of the bowel or just the diagnostics of CD of the small bowel (6,24). The major limitation was the small number of patients.…”

Section: Discussionmentioning

confidence: 99%

The value of combined positron emission tomography/magnetic resonance imaging to diagnose inflammatory bowel disease: a prospective study

et al. 2020

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Background The clinical utility of positron emission tomography/magnetic resonance imaging (PET/MRI) in comparison to standard work-up with patients with known or suspected inflammatory bowel disease (IBD) is unknown. Purpose To evaluate the value of 18F-fluorodeoxyglucose (18F-FDG) PET/MRI in the diagnostics of IBD and further compare the data obtained using PET/MRI to histological findings. Materials and Methods Ten patients with relapse in IBD or with symptoms of suspected IBD were recruited either from a gastroenterology outpatient clinic or from a hospital ward. Intestinal inflammation was assessed with histology and 18F-FDG PET/MRI. Maximum standard uptake values (SUVmax) were calculated in six regions of the intestine (small bowel, ascending, transverse, descending and sigmoid colon, and rectum) and compared to histological analysis of inflammation activity. Results The study showed that both the inflammation activity ( P = 0.008) and the region of the biopsy in the intestine ( P = 0.015) had a significant effect on SUV. SUVs obtained from severe inflammation activity emerged significantly from the background ( P = 0.006). In addition, the SUVs obtained from moderate inflammation raised from background, but the difference was not statistically significant ( P = 0.083), while SUVs of mild inflammation were at the same level with SUVs of normal bowel wall ( P = 0.988). Conclusion 18F-FDG PET/MRI is a promising method of detecting especially severe inflammatory bowel lesions. More data are required to define its sensitivity and specificity.

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Section: Discussionmentioning

confidence: 99%

The value of combined positron emission tomography/magnetic resonance imaging to diagnose inflammatory bowel disease: a prospective study

et al. 2020

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“…The results of the present study suggest an association between systemic inflammation and 18 F‐FDG‐PETCT‐derived measures of tumour metabolism in patients with recurrent colorectal cancer. 18 F‐FDG‐PETCT has been used to assess disease response and has been reported to be prognostic in patients with colorectal cancer ; however, very little prior work has been carried out in the context of systemic inflammatory response . To the authors’ knowledge, this is the first study to directly examine the relationship between 18 F‐FDG‐PETCT parameters and measures of systemic inflammation in colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

The relationship between ¹⁸F‐FDG‐PETCT‐derived markers of tumour metabolism and systemic inflammation in patients with recurrent disease following surgery for colorectal cancer

et al. 2018

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“…Jacene et al [ 29 ] have shown on PET/CT that the product of metabolically active volume (corrected to background) and SUVmean is correlated with Crohn's disease endoscopy index of severity (CDEIS). Russo et al [ 30 ] demonstrated that SUVmax corrected to body lean mass was superior to the total inflammatory volume in differentiating fibrotic from transmural inflammatory stenosis.…”

Section: Discussionmentioning

confidence: 99%

Correlation of 18F-FDG PET/MRE Metrics with Inflammatory Biomarkers in Patients with Crohn’s Disease: A Pilot Study

Domachevsky

Leibovitzh

Avni-Biron

et al. 2017

Contrast Media & Molecular Imaging

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Background To investigate the association between 18F-FDG (Fluorodeoxyglucose) PET (positron emission tomography)/MRE (magnetic resonance enterography) metrics with the inflammatory biomarkers fecal calprotectin and C-reactive protein (CRP) in patients with Crohn's disease (CD). Methods This prospective pilot study was institutional review board (IRB) approved with informed consent obtained. Consecutive CD patients were referred to 18F-FDG PET/MRE. Patients in whom colonoscopy was performed and CRP and fecal calprotectin levels were measured were included. CRP and fecal calprotectin were regarded as positive for inflammation if they were greater than 0.5 mg/dl and 150 mcg/g, respectively. Correlation of quantitative variables was performed using the Pearson's correlation coefficient. Receiver operating characteristic (ROC) curves were drawn and the area under the curve (AUC) was calculated to evaluate the accuracy of PET and MRE metrics in determining the presence of inflammation evaluated by calprotectin and CRP levels. Results Analysis of 21 patients (16 women and 5 men, 43 ± 18 years) was performed. Magnetic resonance index of activity (MaRIA) score had an AUC of 0.63 associated with fecal calprotectin and CRP. Adding apparent diffusion coefficient (ADC) and metabolic inflammatory volume (MIV) to MaRIA score resulted in an AUC of 0.92 with a cutoff value of 447 resulting in 83% and 100% sensitivity and specificity, respectively. Conclusion The addition of ADC and MIV to the MaRIA score increases the accuracy for discrimination of disease activity in patients with CD. Trial registration number is 2015062.

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Role of 18F-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohnʼs Disease

Cited by 14 publications

References 41 publications

The value of combined positron emission tomography/magnetic resonance imaging to diagnose inflammatory bowel disease: a prospective study

The value of combined positron emission tomography/magnetic resonance imaging to diagnose inflammatory bowel disease: a prospective study

The relationship between ¹⁸F‐FDG‐PETCT‐derived markers of tumour metabolism and systemic inflammation in patients with recurrent disease following surgery for colorectal cancer

Correlation of 18F-FDG PET/MRE Metrics with Inflammatory Biomarkers in Patients with Crohn’s Disease: A Pilot Study

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Role of 18F-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohnʼs Disease

Cited by 14 publications

References 41 publications

The value of combined positron emission tomography/magnetic resonance imaging to diagnose inflammatory bowel disease: a prospective study

The value of combined positron emission tomography/magnetic resonance imaging to diagnose inflammatory bowel disease: a prospective study

The relationship between 18F‐FDG‐PETCT‐derived markers of tumour metabolism and systemic inflammation in patients with recurrent disease following surgery for colorectal cancer

Correlation of 18F-FDG PET/MRE Metrics with Inflammatory Biomarkers in Patients with Crohn’s Disease: A Pilot Study

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The relationship between ¹⁸F‐FDG‐PETCT‐derived markers of tumour metabolism and systemic inflammation in patients with recurrent disease following surgery for colorectal cancer