Correlation of 18F-FDG PET/MRE Metrics with Inflammatory Biomarkers in Patients with Crohn’s Disease: A Pilot Study

Domachevsky, Liran; Leibovitzh, Haim; Avni-Biron, Irit; Lichtenstein, Lev; Goldberg, Natalia; Nidam, Meital; Groshar, David; Bernstine, Hanna; Ben‐Bassat, Ofer

doi:10.1155/2017/7167292

Cited by 11 publications

(8 citation statements)

References 30 publications

(38 reference statements)

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“…Semi-quantitative analysis : SUV max is the more validated semi-quantitative parameter for the evaluation of glucose uptake in IBD. To date, no defined cut-off has been identified to differentiate positive and negative findings [ 228 , 234 ]. However, a comparison between SUV max of the bowel segments involved and liver is encouraged.…”

Section: Resultsmentioning

confidence: 99%

“…[ 18 F]FDG PET/CT could be co-registered to MRI, rather than CT, significantly improving diagnostic morphological information about bowel wall and decreasing the radiation dose [ 228 , 234 , 235 ]. In different clinical protocols, [ 18 F]FDG-WBC PET/CT demonstrated a higher specificity than [ 18 F]FDG PET/CT, showing a lower radiopharmaceutical uptake in healthy GI and urinary tract, but it needs further studies [ 222 , 225 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

State of the art of 18F-FDG PET/CT application in inflammation and infection: a guide for image acquisition and interpretation

Casali

Lauri

Altini

et al. 2021

Clin Transl Imaging

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Aim The diagnosis, severity and extent of a sterile inflammation or a septic infection could be challenging since there is not one single test able to achieve an accurate diagnosis. The clinical use of 18F-fluorodeoxyglucose ([ 18 F]FDG) positron emission tomography/computed tomography (PET/CT) imaging in the assessment of inflammation and infection is increasing worldwide. The purpose of this paper is to achieve an Italian consensus document on [ 18 F]FDG PET/CT or PET/MRI in inflammatory and infectious diseases, such as osteomyelitis (OM), prosthetic joint infections (PJI), infective endocarditis (IE), prosthetic valve endocarditis (PVE), cardiac implantable electronic device infections (CIEDI), systemic and cardiac sarcoidosis (SS/CS), diabetic foot (DF), fungal infections (FI), tuberculosis (TBC), fever and inflammation of unknown origin (FUO/IUO), pediatric infections (PI), inflammatory bowel diseases (IBD), spine infections (SI), vascular graft infections (VGI), large vessel vasculitis (LVV), retroperitoneal fibrosis (RF) and COVID-19 infections. Methods In September 2020, the inflammatory and infectious diseases focus group (IIFG) of the Italian Association of Nuclear Medicine (AIMN) proposed to realize a procedural paper about the clinical applications of [ 18 F]FDG PET/CT or PET/MRI in inflammatory and infectious diseases. The project was carried out thanks to the collaboration of 13 Italian nuclear medicine centers, with a consolidate experience in this field. With the endorsement of AIMN, IIFG contacted each center, and the pediatric diseases focus group (PDFC). IIFG provided for each team involved, a draft with essential information regarding the execution of [ 18 F]FDG PET/CT or PET/MRI scan (i.e., indications, patient preparation, standard or specific acquisition modalities, interpretation criteria, reporting methods, pitfalls and artifacts), by limiting the literature research to the last 20 years. Moreover, some clinical cases were required from each center, to underline the teaching points. Time for the collection of each report was from October to December 2020. Results Overall, we summarized 291 scientific papers and guidelines published between 1998 and 2021. Papers were divided in several sub-topics and summarized in the following paragraphs: clinical indications, image interpretation criteria, future perspectivess and new trends (for each single disease), while patient preparation, image acquisition, possible pitfalls and

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

State of the art of 18F-FDG PET/CT application in inflammation and infection: a guide for image acquisition and interpretation

Casali

Lauri

Altini

et al. 2021

Clin Transl Imaging

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“…Over the past few years attention has turned to the possible role of FDG-PET/MRI scanners, which has the potential to not only combine the good image qualities of MRI, a well-known tool in IBD, with the functional component of FDG-PET, but also to reduce the radioactive burden. In a prospective pilot study enrolling 21 patients with known CD, Domachevsky et al found that adding apparent diffusion coefficient (ADC) and metabolic inflammatory volume (MIV) to MaRIA score resulted in an AUC of 0.92 (compared to MaRIA alone with an AUC of 0.63) resulting in 83% sensitivity and 100% specificity 41 .…”

Section: Novel Approaches -Quantification and Pet/mrimentioning

confidence: 99%

FDG-PET/CT in Inflammatory Bowel Disease

Brodersen

Hess

2020

PET Clinics

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CT has shown promise in inflammatory bowel disease with generally good sensitivity and specificity in various settings, but its overall role is controversial  Many issues remain unresolved and there is no consensus on imaging protocol in the literature-more studies with stringent methodology are needed  Combining FDG-PET with CT or MR enterography yields more information than either exam alone  At present the most promising roles are assessment of early treatment response and stricture characterization, whereas general use in the initial diagnostic workup should be reserved for equivocal cases Synopsis FDG-PET/CT has potential in inflammatory bowel disease-the literature generally presents good sensitivity and specificity in various settings. At present, the most promising roles are assessment of early treatment response and stricture characterization, whereas general use in the initial diagnostic workup should be reserved for equivocal cases for the time being. However, it is challenging to image the moving and physiologically active bowel with FDG and the available literature is far from ideal; studies are generally small, and methodologies are highly variable with regards to imaging parameters, clinical features, treatment regimen, and reference standards. Thus, several issues remain unclarified, and further data is needed to make firm conclusions on the role of FDG and PET/CT in inflammatory bowel disease.

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“…With the often younger population of IBD-patients in mind, this disease complex may be one of the most interesting indications for hybrid PET/MRI, and several reports are emerging within several of the aforementioned subdomains. In 21 consecutive CD patients, Domachevsky et al demonstrated the correlation between imaging and biomarkers with an increase in AUC from 0.63 to 0.92 with sensitivity and specificity of 83% and 100%, respectively, and concluded that FDG-PET/MRI significantly increased accuracy in discriminating active from non-active inflammation(64). This correlation may even be present in pre-symptomatic subclinical patients; Shih et al found correlating increased ADC and SUVmax in bowel segments with corresponding endoscopic signs of active inflammation even in patients in perceived clinical and biochemical remission(65).…”

mentioning

confidence: 99%