Role for neutrophil-derived myeloperoxidase in promoting acute colitis; inhibition of disease progression with 4-Methoxy TEMPO

Chami, Belal; Vallejo, Abigail; Kum-Jew, Stephen; Dickerhof, Nina; Kettle, Anthony J.; Dennis, Joanne M.; Witting, Paul K.

doi:10.1016/j.freeradbiomed.2018.04.131

Cited by 2 publications

(2 citation statements)

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“…MPO activity is an important factor for evaluating the infiltration degree in inflammatory immune cells, mainly neutrophils, in colon tissues. 52 As shown in Figure 5K, there was a significant increase in MPO activity in the DSS group as compared to the control group. As expected, NOB, NEF, and NEFY all reduced the activity of MPO.…”

Section: ■ Results and Discussionmentioning

confidence: 75%

“…All treatment groups could decrease the spleen weight, but NEFY showed the most significant results. MPO activity is an important factor for evaluating the infiltration degree in inflammatory immune cells, mainly neutrophils, in colon tissues . As shown in Figure K, there was a significant increase in MPO activity in the DSS group as compared to the control group.…”

Section: Resultsmentioning

confidence: 99%

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Highly Effective Nobiletin–MPN in Yeast Microcapsules for Targeted Modulation of Oxidative Stress, NLRP3 Inflammasome Activation, and Immune Responses in Ulcerative Colitis

Yang,

Xia,

et al. 2024

J. Agric. Food Chem.

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Inflammatory bowel disease (IBD) etiology is intricately linked to oxidative stress and inflammasome activation. Natural antioxidant nobiletin (NOB) contains excellent anti-inflammatory properties in alleviating intestinal injury. However, the insufficient water solubility and low bioavailability restrict its oral intervention for IBD. Herein, we constructed a highly efficient NOB-loaded yeast microcapsule (YM, NEFY) exhibiting marked therapeutic efficacy for dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) at a low oral dose of NOB (20 mg/kg). We utilized the metal polyphenol network (MPN) formed by selfassembly of epigallocatechin gallate (EGCG) and FeCl 3 as the intermediate carrier to improve the encapsulation efficiency (EE) of NOB by 4.2 times. These microcapsules effectively alleviated the inflammatory reaction and oxidative stress of RAW264.7 macrophages induced by lipopolysaccharide (LPS). In vivo, NEFY with biocompatibility enabled the intestinal enrichment of NOB through controlled gastrointestinal release and macrophage targeting. In addition, NEFY could inhibit NLRP3 inflammasome and balance the macrophage polarization, which favors the complete intestinal mucosal barrier and recovery of colitis. Based on the oral targeted delivery platform of YM, this work proposes a novel strategy for developing and utilizing the natural flavone NOB to intervene in intestinal inflammation-related diseases.

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Section: ■ Results and Discussionmentioning

confidence: 75%

Section: Resultsmentioning

confidence: 99%