Rola neurotroficznego czynnika pochodzenia mózgowego w kontroli łaknienia

Piotrowicz, Zofia; Chalimoniuk, Małgorzata; Czuba, Miłośz; Langfort, Józef

doi:10.18388/pb.2020_340

Cited by 7 publications

(2 citation statements)

References 74 publications

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“…Nevertheless, we should consider that BDNF is also involved in the hypothalamic appetite-regulating network [ 48 ], with anorexigenic effects induced by its central administration [ 49 ]. The plasma levels of BDNF were lower in people suffering from anorexia, compared to healthy subjects, whereas the BDNF concentration tends to arise after normalization of body weight [ 50 ]. In this context, we hypothesize that BDNF modulation could be involved in the anorexigenic effect induced by J. curcas administration in rats [ 51 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Biological Properties of Two Jatropha Species: Different Parts and Different Extraction Methods

et al. 2021

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Jatropha L. species, in particular, J. curcas and J. gossypiifolia, are well known medicinal plants used for treating various diseases. In the present study, leaf and stem bark extracts of J. curcas and J. gossypiifolia obtained by maceration or homogenizer assisted extraction, were investigated for their phytochemical contents and biological potential as antioxidants, enzyme inhibitors and neuromodulators. In this regard, the gene expression of tumor necrosis factor α (TNFα) and brain-derived neurotrophic factor (BDNF) was investigated in hypothalamic HypoE22 cells. Finally, a bioinformatics analysis was carried out with the aim to unravel the putative mechanisms consistent with both metabolomic fingerprints and pharmacological effects. The leaf extracts of J. curcas showed higher total phenolic content (TPC) and total flavonoid content (TFC) than the stem bark extracts (range: 5.79–48.95 mg GAE/g and 1.64–13.99 mg RE/g, respectively), while J. gossypiifolia possessed TPC and TFC in the range of 42.62–62.83 mg GAE/g and 6.97–17.63 mg RE/g, respectively. HPLC-MS/MS analysis revealed that the leaf extracts of both species obtained by homogenizer assisted extraction are richer in phytochemical compounds compared to the stem bark extracts obtained by the same extraction method. In vitro antioxidant potentials were also demonstrated in different assays (DPPH: 6.89–193.93 mg TE/g, ABTS: 20.20–255.39 mg TE/g, CUPRAC: 21.07–333.30 mg TE/g, FRAP: 14.02–168.93 mg TE/g, metal chelating activity: 3.21–17.51 mg EDTAE/g and phosphomolybdenum assay: 1.76–3.55 mmol TE/g). In particular, the leaf extract of J. curcas and the stem bark extract of J. gossypiifolia, both obtained by homogenizer assisted extraction, showed the most potent antioxidant capacity in terms of free radical scavenging and reducing activity, which could be related to their higher TPC and TFC. Furthermore, anti-neurodegenerative (acetylcholinesterase inhibition:1.12–2.36 mg GALAE/g; butyrylcholinetserase inhibition: 0.50–3.68 mg GALAE/g), anti-hyperpigmentation (tyrosinase inhibition: 38.14–57.59 mg KAE/g) and antidiabetic (amylase inhibition: 0.28–0.62 mmol ACAE/g; glucosidase inhibition: 0.65–0.81 mmol ACAE/g) properties were displayed differentially by the different extracts. Additionally, the extracts were effective in reducing the gene expression of both TNFα and BDNF, which could be partially mediated by phenolic compounds such as naringenin, apigenin and quercetin. Indeed, the scientific data obtained from the present study complement the several other reports highlighting the pharmacological potentials of these two species, thus supporting their uses as therapeutically active plants.

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Section: Resultsmentioning

confidence: 99%

Chemical Composition and Biological Properties of Two Jatropha Species: Different Parts and Different Extraction Methods

et al. 2021

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“…Increased CRP levels has demonstrated a causal role in onset of adult obesity (Li, Q et al., 2020). Leptin and ghrelin are known to be regulatory markers for satiety and hunger (O'Rourke et al., 2019, Piotrowicz et al, 2020). Adiponectin plays an important role in energy metabolism and hence shares an inversely proportional relationship with BMI and visceral fat accumulation (Nigro et al., 2014).…”

Section: Resultsmentioning

confidence: 99%

Genetic architecture of adiposity measures among Asians: Findings from GWAS

Agarwal,

Lyngdoh,

Khadgawat

et al. 2023

Annals of Human Genetics

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Adiposity has gradually become a global public threat over the years with drastic increase in the attributable deaths and disability adjusted life years (DALYs). Given an increased metabolic risk among Asians as compared to Europeans for any given body mass index (BMI) and considering the differences in genetic architecture between them, the present review aims to summarize the findings from genome‐wide scans for various adiposity indices and related anthropometric measures from Asian populations. The search for related studies, published till February 2022, were made on PubMed and GWAS Catalog using search strategy built with relevant keywords joined by Boolean operators. It was recorded that out of a total of 47 identified studies, maximum studies are from Korean population (n = 14), followed by Chinese (n = 7), and Japanese (n = 6). Nearly 200 loci have been identified for BMI, 660 for height, 16 for weight, 28 for circumferences (waist and hip), 32 for ratios (waist hip ratio [WHR] and thoracic hip ratio [THR]), 5 for body fat, 16 for obesity, and 28 for adiposity‐related blood markers among Asians. It was observed that though, most of the loci were unique for each trait, there were 3 loci in common to BMI and WHR. Apart from validation of variants identified in European setting, there were many novel loci discovered in Asian populations. Notably, 125 novel loci form Asian studies have been reported for BMI, 47 for height, 5 for waist circumference, and 2 for adiponectin level to the existing knowledge of the genetic framework of adiposity and related measures. It is necessary to examine more advanced adiposity measures, specifically of relevance to abdominal adiposity, a major risk factor for cardiometabolic disorders among Asians. Moreover, in spite of being one continent, there is diversity among different ethnicities across Asia in terms of lifestyle, climate, geography, genetic structure and consequently the phenotypic manifestations. Hence, it is also important to consider ethnic specific studies for identifying and validating reliable genetic variants of adiposity measures among Asians.

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Hungry brain: about the possible contribution of neurotrophic factors to anorexia nervosa

Iwanicka,

Mazgaj,

Mazur

et al. 2024

Curr Probl Psychiatry

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Introduction: Anorexia nervosa (AN) is an eating disorder characterized by restricted energy intake leading to weight loss below the healthy range. It is accompanied by anxiety and distorted body perception. While the disorder often manifests during adolescence, there is a noted decrease in the average age of onset, with an increasing number of cases in childhood. Successful treatment and maintenance of healthy body weight require an understanding of the complex etiology of AN, encompassing both psychosocial and specific biological factors. Material and methods: For the review, databases PubMed, Cochrane, and Google Scholar were utilized, searching for the following keywords: anorexia nervosa, neurotrophins, neurotrophin 3, neurotrophin 4, BDNF, nerve growth factor, from the inception of the databases until September 2023. Discussion: In the biological context, neurotrophic growth factors such as neurotrophin 3 (NT-3), neurotrophin 4 (NT-4), brainderived neurotrophic factor (BDNF), and nerve growth factor (NGF) may play a significant role in the etiopathogenesis of AN. These substances are involved in processes such as neuroprotection, proliferation, maturation, and survival of neurons in both the central and peripheral nervous systems. They regulate neuronal plasticity, impact the production of neurotransmitters, and control synaptic activity. BDNF and neurotrophin 3 influence the serotoninergic and noradrenergic systems, which may be associated with neurobiological processes responsible for anxiety and mood disorders. Conclusions: Understanding the role of neurotrophins in AN has the potential to lead to more effective and personalized therapies, enabling a better comprehension of the biological mechanisms of this disorder and the development of targeted pharmacological interventions. Keywords: anorexia nervosa, bdnf, neurotrophin 3, neurotrophin 4, nerve growth factor

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Rola neurotroficznego czynnika pochodzenia mózgowego w kontroli łaknienia

Cited by 7 publications

References 74 publications

Chemical Composition and Biological Properties of Two Jatropha Species: Different Parts and Different Extraction Methods

Chemical Composition and Biological Properties of Two Jatropha Species: Different Parts and Different Extraction Methods

Genetic architecture of adiposity measures among Asians: Findings from GWAS

Hungry brain: about the possible contribution of neurotrophic factors to anorexia nervosa

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