Rodolfo Hinostroza In Memoriam (Lima, Perú, 1941 - Lima, Perú, 2016)

Cozman, Camilo Fernández

doi:10.30920/letras.87.126.10

Cited by 2 publications

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“…The system consists of a "dome" FAIMS [33][34][35] unit orthogonally attached to the source region of a custom built TIMS-TOF MS (Bruker Daltonics Inc., MA). [36][37] Ions were generated using a nESI emitter supported by a XYZ stage. Emitters were made from a quartz capillary (o.d.…”

Section: Nesi-faims-tims-tof Ms Instrumentmentioning

confidence: 99%

“…The nESI-FAIMS-TIMS-TOF MS measurements were carried out using N 2 as a buffer gas at constant velocity defined by the pressure difference between the funnel entrance (P 1 = 2.6 mbar) and exit (P 2 = 1.1 mbar) at ca. 300 K. [36][37] The TIMS radio frequency (rf) voltage was 250 Vpp at a frequency of 880 kHz. To avoid potential ion activation prior to the mobility analysis, "soft" ion transmission and trapping conditions were maintained in all experiments.…”

Section: Nesi-faims-tims-tof Ms Instrumentmentioning

confidence: 99%

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Structural Heterogeneity of Human Histone H2A.1

2021

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Histones are highly basic chromatin proteins that tightly package and order eukaryotic DNA into nucleosomes. While the atomic structure of the nucleosomes has been determined, the three-dimensional structure of DNA-free histones remains unresolved. Here, we combine tandem non-linear and linear ion mobility spectrometry (FAIMS-TIMS) coupled to mass spectrometry in parallel with molecular modeling to study the conformational space of a DNA-free histone H2A type 1 (H2A.1). Experimental results showed the dependence of the gas-phase structures with the starting solution conditions, characterized by charge state distributions, mobility distributions, and collision-induced-unfolding (CIU) pathways. The measured H2A.1 gas-phase structures showed a high diversity of structural features ranging from compact to partially folded, and then highly elongated conformations. Molecular dynamic simulations provided candidate structures for the solution H2A.1 native conformation with folded N-and C-terminal tails, as well as gas phase candidate structures associated with the mobility trends. Complementary CCS and dipole calculations showed that the charge distribution in the case of elongated gas-phase structures, where basic and acidic residues are mostly exposed (e.g., z > 15+), is sufficient to induce differences in the dipole alignment at high electric fields, in good agreement with the trends observed during the FAIMS-TIMS experiments.

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Section: Nesi-faims-tims-tof Ms Instrumentmentioning

confidence: 99%

Section: Nesi-faims-tims-tof Ms Instrumentmentioning

confidence: 99%

Structural Heterogeneity of Human Histone H2A.1

2021

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“…10. Fernández Cozman, 2016, p. 85. HIPOGRIFO, 12.1, 2024 cilaso», elevado a la «categoría de símbolo de la peruanidad» 11 .…”

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«Comentarios reales» (1964) de Antonio Cisneros y «Poderes secretos» (1995) de Miguel Gutiérrez: su relación con el paradigma garcilasista

Pollarolo

2024

Hipogrifo

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Resumen. Comentarios reales (1964), el poemario de Antonio Cisneros, y el ensayo-novela Poderes secretos (1995), de Miguel Gutiérrez, se proponen «revisar», «desmitificar», «desestabilizar» los discursos de y sobre el Inca Garcilaso. En el presente trabajo, analizo la manera en que ambos autores dialogan con estos discursos que, aun cuando se enfrenten y opongan, se inscriben en el mismo paradigma: el de la condición mestiza del Inca. Intentaré mostrar que el poeta Cisneros y el narrador Gutiérrez elaboran sus textos desde la confrontación, el cuestionamiento y la crítica tanto al hispanismo de la generación del 900, liderado por José de la Riva Agüero, como al antihispanismo de Luis E. Valcárcel, y luego, aun cuando son posteriores a la escritura del poemario de Cisneros, a los nuevos enfoques de los estudios literarios coloniales hispanoamericanos.

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Rodolfo Hinostroza In Memoriam (Lima, Perú, 1941 - Lima, Perú, 2016)

Cited by 2 publications

References 0 publications

Structural Heterogeneity of Human Histone H2A.1

Structural Heterogeneity of Human Histone H2A.1

«Comentarios reales» (1964) de Antonio Cisneros y «Poderes secretos» (1995) de Miguel Gutiérrez: su relación con el paradigma garcilasista

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