Rodent models for the study of type 2 diabetes in children (juvenile diabesity)

Mathews, Clayton E.

doi:10.1034/j.1399-5448.2002.30307.x

Cited by 3 publications

(2 citation statements)

References 126 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that this model is insulin responsive and represents a model of maturity-onset diabetes of the young with insulin resistance. These mice are commercially available through the Jackson Laboratories (Mathews 2002). The Ins2 gene is the mouse homolog of human preproinsulin gene that causes misfolding of the insulin protein.…”

Section: Insulin-2 Akita Micementioning

confidence: 99%

See 1 more Smart Citation

Rodent animal models: from mild to advanced stages of diabetic nephropathy

et al. 2014

View full text Add to dashboard Cite

Diabetic nephropathy (DN) is a secondary complication of both type 1 and type 2 diabetes, resulting from uncontrolled high blood sugar. 30-40% of diabetic patients develop DN associated with a poor life expectancy and end-stage renal disease, causing serious socioeconomic problems. Although an exact pathogenesis of DN is still unknown, several factors such as hyperglycemia, hyperlipidemia, hypertension and proteinuria may contribute to the progression of renal damage in diabetic nephropathy. DN is confirmed by measuring blood urea nitrogen, serum creatinine, creatinine clearance and proteinuria. Clinical studies show that intensive control of hyperglycemia and blood pressure could successfully reduce proteinuria, which is the main sign of glomerular lesions in DN, and improve the renal prognosis in patients with DN. Diabetic rodent models have traditionally been used for doing research on pathogenesis and developing novel therapeutic strategies, but have limitations for translational research. Diabetes in animal models such as rodents are induced either spontaneously or by using chemical, surgical, genetic, or other techniques and depicts many clinical features or related phenotypes of the disease. This review discusses the merits and demerits of the models, which are used for many reasons in the research of diabetes and diabetic complications.

show abstract

Section: Insulin-2 Akita Micementioning

confidence: 99%

“…This model is insulin responsive, causing severe DN. It also shows histological changes at 4-35 weeks (Mathews 2002). Ins2Akita mice could be used as a substitute for mice that are rendered insulin-dependent diabetic by treatment with alloxan or STZ (Ron 2002).…”

Section: Merits and Demeritsmentioning

confidence: 99%