Robustness testing of milling process, analyzing the particle size distribution and crystallinity of the milled samples
Csaba Bartos,
Orsolya Jójárt-Laczkovich,
Géza Regdon
et al.
Abstract:The aim of this work was to discover the robustness of combined wet milling process to determine the interval of the Mel (meloxicam) amount and to predict the degree of crystallinity of the milled samples using DSC and XRPD measurements. The samples had the poly(vinyl alcohol) (PVA) as the stabilizing agent. By increasing the amount of the Mel, its crystallinity increased and close correlation was found between the degree of crystallinity and the Mel amount. To achieve the desired particle size range (100-500 … Show more
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