Robust thermal control for CMOS-based lab-on-chip systems

Martinez-Quijada, Jose; Ma, Tingxuan; Hall, Gordon H.; Reynolds, Matt; Sloan, David; Caverhill-Godkewitsch, Saul; Glerum, D. Moira; Sameoto, Dan; Elliott, D.G.; Backhouse, C.

doi:10.1088/0960-1317/25/7/075005

Cited by 7 publications

(3 citation statements)

References 30 publications

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“…CMOS based processes have the ability to provide us with such precise microheaters, which can enable efficient and portable DNA analysis devices. This had been a challenge in the past, but Martinez‐Quijada et al invented a fast, low‐power thermal control which permits millimeter‐scaled thermally independent regions . The design was optimized for LOC devices that can be integrated with standard CMOS processes.…”

Section: Role Of Cmos In Microfluidicsmentioning

confidence: 99%

CMOS Enabled Microfluidic Systems for Healthcare Based Applications

et al. 2018

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additional parts, such as syringe pumps, control valves, and microscopes, which not only increase the complexity and cost of the system but also create a dependence of the system on a laboratorybased environment. Technology has now advanced so much that there are fully integrated sample-in-results-out chips for genetic analysis, [8] sensors that can detect a handful of molecules, and many other similar systems. [9] Complementary metal oxide semiconductor (CMOS) integrated LOC systems can be developed using CMOS technologies as sensors, signal conditioners, data processing circuitry, actuators, and wireless communication capabilities. [10][11][12][13][14][15][16][17] CMOS is a set of microfabrication and nanofabrication processes, which is used to manufacture semiconductor chips present inside computer, smartphone, or any electronic gadgets. Consequently, these chips are referred to as CMOS enabled or CMOS based chips. CMOS based chips can act as a processor, memory, and digital logic circuitry for data management. In this review, we will discuss how CMOS based devices have enabled both management of data from microfluidic devices as well as sensors and actuators to help complement the functionality of LOC devices. CMOS logics are simple to make, and consume little to no current in idle state. With the advancements in Moore's law we have seen the size of CMOS devices getting smaller and smaller allowing for more functionality to fit in a smaller area. [18] CMOS plays a significant role in the realization of portable and versatile microfluidic platforms by integrating them with microscale sensors, interfaces, and actuators to form autonomous hybrid systems. [10,12,16] Adding interface electronics to the same CMOS chip as sensors, actuators, data processing, and communication capabilities creates a universal platform for LOC technologies. Having signal amplification and noise removal right at the sensor interface without any signal loss makes the device output more accurate and sensitive, and also removes parasitic and mismatch errors. [1] By using CMOScompatible processes, it is possible to interface directly with the readout circuitry to form an integrated circuit system on a single chip. Signal acquisition from a large array of sensors to a single system requires a complex integration scheme, but CMOS microfabrication processes enable the integration of analogue multiplexers with biosensors on small dice. [19] CMOS also has the capability to actuate pumps and valves in microfluidic devices or to directly influence the fluid itself using electric With the increased global population, it is more important than ever to expand accessibility to affordable personalized healthcare. In this context, a seamless integration of microfluidic technology for bioanalysis and drug delivery and complementary metal oxide semiconductor (CMOS) technology enabled data-management circuitry is critical. Therefore, here, the fundamentals, integration aspects, and applications of CMOS-enabled microfluidic systems for affordable persona...

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Section: Role Of Cmos In Microfluidicsmentioning

confidence: 99%

CMOS Enabled Microfluidic Systems for Healthcare Based Applications

et al. 2018

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“…This has been a challenge, but Jose et al invented a fast, low-power thermal control which permits millimetre-scaled thermally independent regions. [99] The design was optimized for LOC devices that can be integrated with standard CMOS processes. An aluminium layer stack on a silicon substrate driven by a customdesigned linear voltage-to-current convertor acted as the heater.…”

Section: Microheatersmentioning

confidence: 99%

Personalized Healthcare: CMOS Enabled Microfluidic Systems for Healthcare Based Applications (Adv. Mater. 16/2018)

et al. 2018

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In article number https://doi.org/10.1002/adma.201705759, Muhammad M. Hussain and co‐workers present a comprehensive review on the role of CMOS technology for advanced microfluidics‐based personalized healthcare applications. The advanced and reliable CMOS technology offers a miniaturization opportunity to integrate a broad spectrum of devices involving sensors, actuators, and definitely integrated circuits with standard microfluidic components and operations such as flow cytometry, polymerase chain reaction (PCR) tests, immunoassays, and blood chemistry with an overarching objective: affordability.

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“…Our particular research is directed to the development of a MEMS platform to measure single cell stiffness in a microfluidic environment [6]. This requires the integration of mechanical MEMS devices and microfluidic flows which is a particularly challenging integration problem for cost-effective prototyping or large scale manufacturing [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Direct integration of MEMS, dielectric pumping and cell manipulation with reversibly bonded gecko adhesive microfluidics

Warnat

King

Wasay

et al. 2016

J. Micromech. Microeng.

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We present an approach to form a microfluidic environment on top of MEMS dies using reversibly bonded microfluidics. The reversible polymeric microfluidics moulds bond to the MEMS die using a gecko-inspired gasket architecture. In this study the formed microchannels are demonstrated in conjunction with a MEMS mechanical single cell testing environment for BioMEMS applications. A reversible microfluidics placement technique with an x-y and rotational accuracy of ±2 µm and 1° respectively on a MEMS die was developed. No leaks were observed during pneumatic pumping of common cell media (PBS, sorbitol, water, seawater) through the fluidic channels. Thermal chevron actuators were successful operated inside this fluidic environment and a performance deviation of ~15% was measured compared to an open MEMS configuration. Latex micro-spheres were pumped using traveling wave di-electrophoresis and compared to an open (no-microfluidics) configuration with velocities of 24 µm s−1 and 20 µm s−1.

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Robust thermal control for CMOS-based lab-on-chip systems

Cited by 7 publications

References 30 publications

CMOS Enabled Microfluidic Systems for Healthcare Based Applications

CMOS Enabled Microfluidic Systems for Healthcare Based Applications

Personalized Healthcare: CMOS Enabled Microfluidic Systems for Healthcare Based Applications (Adv. Mater. 16/2018)

Direct integration of MEMS, dielectric pumping and cell manipulation with reversibly bonded gecko adhesive microfluidics

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