Robust on-line sampling and analysis during long-term perfusion cultivation of mammalian cells

Developments and Trends in Industrial Process Analytics for Life Science Applications

“…). Even for continuous cell cultures of more than 100 d fermentation duration, the systems continuously provide significant data and maintain cell culture integrity . Continuous sampling will lead to a significantly higher density of measurement data than manual sampling.…”

Developing the biofacility of the future based on continuous processing and single-use technology

“…The implementation of an automated sampling system, the BaychroMAT ® , was tested during production (Chong et al, 2013). Two BaychroMAT ® systems were installed in the pilot plant and used for automated and sterile sampling at various positions in the process.…”

Process analytical technologies in food industry – challenges and benefits: A status report and recommendations

“…In biopharmaceutical processes, product titers are usually very low, the products are proteins with high molecular weight, and quality attributes are challenging to analyse. In these situations, online sampling with automated sample preparation and analytics may open up a solution [5]. But, identifying and implementing analytical methods, which are fast enough for delivering results on product quality attributes (e.g.…”