Robust intervention for oxidative stress-induced injury in periodontitis via controllably released nanoparticles that regulate the ROS-PINK1-Parkin pathway

Li, Xincong; Zhao, Yue; Peng, Haoran; Gu, Deao; Liu, Chao; Ren, Xiaobing; Miao, Leiying

doi:10.3389/fbioe.2022.1081977

Cited by 10 publications

(8 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ligature-induced periodontitis mice model is a classical experimental model to mimic periodontitis in vivo. Although the exact mechanism of periodontitis pathogenesis is not fully elucidated, many studies have shown that it is linked to ROS-mediated oxidative stress [ 39 ]. Curcumin is a potent antioxidant that facilitates mitochondrial activities, reduces the level of ROS and lipid peroxidation, improves SOD activity and inhibits erastin-induced ferroptosis [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Curcumin Attenuates Periodontal Injury via Inhibiting Ferroptosis of Ligature-Induced Periodontitis in Mice

Wang

Lin

Huang

et al. 2023

IJMS

View full text Add to dashboard Cite

Periodontitis is a chronic infectious disease characterized by the destruction of connective tissue and alveolar bone that eventually leads to tooth loss. Ferroptosis is an iron-dependent regulated cell death and is involved in ligature-induced periodontitis in vivo. Studies have demonstrated that curcumin has a potential therapeutic effect on periodontitis, but the mechanism is still unclear. The purpose of this study was to investigate the protective effects of curcumin on alleviating ferroptosis in periodontitis. Ligature-induced periodontal-diseased mice were used to detect the protective effect of curcumin. The level of superoxide dismutase (SOD), malondialdehyde (MDA) and total glutathione (GSH) in gingiva and alveolar bone were assayed. Furthermore, the mRNA expression levels of acsl4, slc7a11, gpx4 and tfr1 were measured using qPCR and the protein expression of ACSL4, SLC7A11, GPX4 and TfR1 were investigated by Western blot and immunocytochemistry (IHC). Curcumin reduced the level of MDA and increased the level of GSH. Additionally, curcumin was proven to significantly increase the expression levels of SLC7A11 and GPX4 and inhibit the expression of ACSL4 and TfR1. In conclusion, curcumin plays a protective role by inhibiting ferroptosis in ligature-induced periodontal-diseased mice.

show abstract

Section: Discussionmentioning

confidence: 99%

Curcumin Attenuates Periodontal Injury via Inhibiting Ferroptosis of Ligature-Induced Periodontitis in Mice

Wang

Lin

Huang

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Nanoparticles that control the release of MitoQ [183] PDLSC sheets Promoted bone structures and collagen formation LC3 and p62 AuNPs [111] DFCs Increased biomineralization capability LC3A/B, ATG12, and AMPK Autophagy inhibitors [115] GMSCs Accelerated the osteogenic differentiation AMPK-Beclin 1 pathway Resveratrol [184] Note: Abbreviations: AMPK, adenosine monophosphate-activated protein kinase; ATG, autophagy-related proteins; AuNPs, gold nanoparticles; BIO, 6bromoindirubin-3′-oxime; BNIP3/NIX, BCL2 interacting protein 3/NIP3-like protein X signaling; CDs, carbon nanodots; CDots, carbon dots; DFCs, dental follicle cells; DFO, deferoxamine; FA-modified PCL nanofiber, fluorapatite-modified polycaprolactone nanofiber; FGF21, fibroblast growth factor 21; FUNDC1, FUN14 domain containing 1; GMSCs, gingival mesenchymal stem cells; LC3, microtubule-associated protein 1 light chain 3; mTOR-C1, the mechanistic target of rapamycin complex 1; NaF, sodium fluoride; PE, phosphatidylethanolamine; PI3KC3, the class III PI3K; PI3P, phosphatidylinositol-3-phosphate.…”

Section: Inhibited Osteoblastic Differentiation Lc3 Atg5 and P62mentioning

confidence: 99%

An overview of autophagy in the differentiation of dental stem cells

ZHAO,

JU,

et al. 2024

BIOCELL

View full text Add to dashboard Cite

Dental stem cells (DSCs) have attracted significant interest as autologous stem cells since they are easily accessible and give a minimal immune response. These properties and their ability to both maintain self-renewal and undergo multi-lineage differentiation establish them as key players in regenerative medicine. While many regulatory factors determine the differentiation trajectory of DSCs, prior research has predominantly been based on genetic, epigenetic, and molecular aspects. Recent evidence suggests that DSC differentiation can also be influenced by autophagy, a highly conserved cellular process responsible for maintaining cellular and tissue homeostasis under various stress conditions. This comprehensive review endeavors to elucidate the intricate regulatory mechanism and relationship between autophagy and DSC differentiation. To achieve this goal, we dissect the intricacies of autophagy and its mechanisms. Subsequently, we elucidate its pivotal roles in impacting DSC differentiation, including osteo/ odontogenic, neurogenic, and angiogenic trajectories. Furthermore, we reveal the regulatory factors that govern autophagy in DSC lineage commitment, including scaffold materials, pharmaceutical cues, and the extrinsic milieu.The implications of this review are far-reaching, underpinning the potential to wield autophagy as a regulatory tool to expedite DSC-directed differentiation and thereby promote the application of DSCs within the realm of regenerative medicine.

show abstract

“… 45 Li X et al, on the other hand, noted that the reactive oxygen species (ROS) encapsulated in menaquinone (MitoQ; an autophagy enhancer) released the nanoparticle, released menaquinone effectively induced mitochondrial autophagy via the PINK1-Parkin pathway and successfully reduced oxidative stress by decreasing the number of reactive oxygen species, which was beneficial for periodontal regeneration. 67 The study of PDLSCs exosomes (PDLSCs-Exos) has also been gradually increasing. FOR THE FIRST TIME, Liu T et al revealed that miRNAs originating from PDLSCs-Exos might promote the osteogenic differentiation of BMSCs.…”

Section: Dental-derived Mesenchymal Stem Cellsmentioning

confidence: 99%

Nanomaterials Modulating the Fate of Dental-Derived Mesenchymal Stem Cells Involved in Oral Tissue Reconstruction: A Systematic Review

Li,

Wang,

Huang

et al. 2023

IJN

View full text Add to dashboard Cite

The critical challenges in repairing oral soft and hard tissue defects are infection control and the recovery of functions. Compared to conventional tissue regeneration methods, nano-bioactive materials have become the optimal materials with excellent physicochemical properties and biocompatibility. Dental-derived mesenchymal stem cells (DMSCs) are a particular type of mesenchymal stromal cells (MSCs) with great potential in tissue regeneration and differentiation. This paper presents a review of the application of various nano-bioactive materials for the induction of differentiation of DMSCs in oral and maxillofacial restorations in recent years, outlining the characteristics of DMSCs, detailing the biological regulatory effects of various nano-materials on stem cells and summarizing the material-induced differentiation of DMSCs into multiple types of tissue-induced regeneration strategies. Nanomaterials are different and complementary to each other. These studies are helpful for the development of new nanoscientific research technology and the clinical transformation of tissue reconstruction technology and provide a theoretical basis for the application of nanomaterial-modified dental implants. We extensively searched for papers related to tissue engineering bioactive constructs based on MSCs and nanomaterials in the databases of PubMed, Medline, and Google Scholar, using keywords such as "mesenchymal stem cells", "nanotechnology", "biomaterials", "dentistry" and "tissue regeneration". From 2013 to 2023, we selected approximately 150 articles that align with our philosophy.

show abstract

Robust intervention for oxidative stress-induced injury in periodontitis via controllably released nanoparticles that regulate the ROS-PINK1-Parkin pathway

Abstract: Graphical AbstractWe introduce novel mitophagy enhancer, MitoQ@PssL NPs exert excellently anti-inflammatory effects by activating mitophagy and clearing partial mitochondrial ROS, thereby accelarating osteogenesis in periodontitis.

Cited by 10 publications

References 52 publications

Curcumin Attenuates Periodontal Injury via Inhibiting Ferroptosis of Ligature-Induced Periodontitis in Mice

Curcumin Attenuates Periodontal Injury via Inhibiting Ferroptosis of Ligature-Induced Periodontitis in Mice

An overview of autophagy in the differentiation of dental stem cells

Nanomaterials Modulating the Fate of Dental-Derived Mesenchymal Stem Cells Involved in Oral Tissue Reconstruction: A Systematic Review

Contact Info

Product

Resources

About