Nanomaterials Modulating the Fate of Dental-Derived Mesenchymal Stem Cells Involved in Oral Tissue Reconstruction: A Systematic Review

Li, Xingrui; Wang, Yue; Huang, Denghao; Jiang, Zhonghao; He, Zhiyu; Luo, Maoxuan; Lei, Jie; Xiao, Yao

doi:10.2147/ijn.s418675

Cited by 2 publications

(2 citation statements)

References 211 publications

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“…TEM's high magnification and resolution capabilities enabled the visualization of the distribution of AuNPs within specific cellular compartments and that way proved the cellular uptake of 120 nm AuNPs within the cells. According to research, the cellular uptake of AuNPs, as well as their location and their lifespan inside the cell, plays a major role in their radiosensitizing effects and physical mechanisms of action [25]. Even though AuNPs did not seem to enter the nucleus, they were often located near the perinuclear region (Figure 3a,b).…”

Section: Assessment Of Distribution and Localization Of Aunps In Cell...mentioning

confidence: 99%

Nanoparticle-Mediated Radiotherapy: Unraveling Dose Enhancement and Apoptotic Responses in Cancer and Normal Cell Lines

Kouri,

Spyratou,

Kalkou

et al. 2023

Biomolecules

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Cervical cancer remains a pressing global health concern, necessitating advanced therapeutic strategies. Radiotherapy, a fundamental treatment modality, has faced challenges such as targeted dose deposition and radiation exposure to healthy tissues, limiting optimal outcomes. To address these hurdles, nanomaterials, specifically gold nanoparticles (AuNPs), have emerged as a promising avenue. This study delves into the realm of cervical cancer radiotherapy through the meticulous exploration of AuNPs’ impact. Utilizing ex vivo experiments involving cell lines, this research dissected intricate radiobiological interactions. Detailed scrutiny of cell survival curves, dose enhancement factors (DEFs), and apoptosis in both cancer and normal cervical cells revealed profound insights. The outcomes showcased the substantial enhancement of radiation responses in cancer cells following AuNP treatment, resulting in heightened cell death and apoptotic levels. Significantly, the most pronounced effects were observed 24 h post-irradiation, emphasizing the pivotal role of timing in AuNPs’ efficacy. Importantly, AuNPs exhibited targeted precision, selectively impacting cancer cells while preserving normal cells. This study illuminates the potential of AuNPs as potent radiosensitizers in cervical cancer therapy, offering a tailored and efficient approach. Through meticulous ex vivo experimentation, this research expands our comprehension of the complex dynamics between AuNPs and cells, laying the foundation for their optimized clinical utilization.

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Section: Assessment Of Distribution and Localization Of Aunps In Cell...mentioning

confidence: 99%

Nanoparticle-Mediated Radiotherapy: Unraveling Dose Enhancement and Apoptotic Responses in Cancer and Normal Cell Lines

Kouri,

Spyratou,

Kalkou

et al. 2023

Biomolecules

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show abstract

“…The silver nanoparticles (AgNPs) were selected for the growth inhibition of resistant microorganisms including both Gram-positive and Gram-negative, however some reports suggested that these AgNPs can also inhibit the growth of fungi and viruses by disrupting the cell membrane and generating ROS [32].…”

Section: Selection Of Nanoparticlesmentioning

confidence: 99%

Immobilization of silver nanoparticles with gum of Moringa oleifera for effective antibacterial activities against human disease-causing bacterial species

Ali,

Ahmad,

Uddin

et al. 2024

Preprint

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The misuse of antibiotics generates resistant bacterial strains that are extremely dangerous and pose a serious threat to global health systems. This global issue needs a rapid and urgent alternative to control the growth of resistant strains. In this study, a novel strategy was adopted to suppress the growth of resistant pathogens. Here, an immobilization approach was applied using silver nanoparticles (AgNPs) and gum of medicinally important Moringa oleifera. In many studies, the gum and AgNPs alone have proven antibacterial activities. Here, the differential concentrations of AgNPs were immobilized with gum of M. oleifera to investigate its potential against highly resistant pathogens. Immobilization is a powerful technique that is commonly used in pharmaceutics for controlled reactivity and emulsification. The immobilized AgNPs displayed promising activities against highly resistant B. subtilis (23.6mm, 50 µL:200 µL), E. coli (19.3; 75 µL:200 µL), K. pneumoniae (22 mm; 200 µL:200 µL), P. mirabilis (16.3 mm; 100 µL:200 µL), P. aeruginosa (22 mm; 175 µL:200 µL) and S. typhi (19.3; 25 µL: 200 µL) than either AgNPs alone or gum. The immobilized AgNPs released the positive sliver ions and the positively charged nanoparticles (NPs) are attracted by the negatively charged bacterial cells. After attachment and permeation to bacterial cell, the immobilized NPs altering the cell membrane permeability, protein denaturation, causing oxidative stress, deactivating enzymes, generating ROS, DNA damage and changing gene expression level. It has been mechanistically considered that the immobilized AgNPs can kill bacteria by damaging their cell membranes, dephosphorylate tyrosine residues during their signal transduction pathways, cell apoptosis, rupture the organelles and inhibiting the cell division and finally lead to cell death. This study has a potential to be adopted by pharmaceutical industries as highly effective antibacterial alternatives to synthetic drugs.

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Nanomaterials Modulating the Fate of Dental-Derived Mesenchymal Stem Cells Involved in Oral Tissue Reconstruction: A Systematic Review

Cited by 2 publications

References 211 publications

Nanoparticle-Mediated Radiotherapy: Unraveling Dose Enhancement and Apoptotic Responses in Cancer and Normal Cell Lines

Nanoparticle-Mediated Radiotherapy: Unraveling Dose Enhancement and Apoptotic Responses in Cancer and Normal Cell Lines

Immobilization of silver nanoparticles with gum of Moringa oleifera for effective antibacterial activities against human disease-causing bacterial species

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