Robust hemostatic bandages based on nanoclay electrospun membranes

Abstract

Death from acute hemorrhage is a major problem in military conflicts, traffic accidents, and surgical procedures, et al. Achieving rapid effective hemostasis for pre-hospital care is essential to save lives in massive bleeding. An ideal hemostasis material should have those features such as safe, efficient, convenient, economical, which remains challenging and most of them cannot be achieved at the same time. In this work, we report a rapid effective nanoclay-based hemostatic membranes with nanoclay particles incorporate into polyvinylpyrrolidone (PVP) electrospun fibers. The nanoclay electrospun membrane (NEM) with 60 wt% kaolinite (KEM1.5) shows better and faster hemostatic performance in vitro and in vivo with good biocompatibility compared with most other NEMs and clay-based hemostats, benefiting from its enriched hemostatic functional sites, robust fluffy framework, and hydrophilic surface. The robust hemostatic bandages based on nanoclay electrospun membrane is an effective candidate hemostat in practical application.

Gold@Halloysite nanotubes-chitin composite hydrogel with antibacterial and hemostatic activity for wound healing

“…Moreover, most of the commercial wound healing dressing materials, such as gelatin, hyaluronic acid, and alginic acid hydrogels, have poor hemostatic function. The addition of porous and negatively-charged HNTs endows the hydrogel with superior hemostatic properties [ 10 , 19 ]. Clinical treatment of wound by this hydrogel materials is based on photothermal of Au NPs loaded in HNTs lumen and soft chitin hydrogel matrix, rather than using anti-inflammatory drugs, which reduces the risk of allergic reactions in patients.…”

“…However, as a clay powder, HNTs are difficult to handle in practical applications for wound care. So, HNTs were usually mixed with polymer matrix or coated on polymer fiber surface to prepare composite dressing [ 19 ]. As a wound dressing, hydrogel materials have many advantages, which can not only seal the wound blood vessels to achieve the purpose of hemostasis [ 20 , 21 ] but also provide a moist environment to prevent infection and accelerate wound healing [ 22 , 23 ].…”

Recent advances in biopolymer-based hemostatic materials

“…Among them, electrospun nanofibrous sheets have gained much attention due to their simplicity and large-scale production [ 226 ]. For example, Cui et al [ 228 ] recently reported a nanoclay-based polyvinyl pyrrolidine (PVP) hemostatic nanofiber membranes ( Fig. 7A–F ).…”

“…The insets are the corresponding 5× magnification of the images (scale bar = 2 µm). Images adapted with permission from Cui et al [ 228 ]. SEM images of anticoagulated whole blood in contact with (RADA16-I/dextran sulfate) 200 films ( G and H ) and (RADA16/HA) 200 films ( I and J ) show interaction of the films with the blood components (scale bar = 10 µm).…”

Multi-crosslinking hydrogels with robust bio-adhesion and pro-coagulant activity for first-aid hemostasis and infected wound healing

“…Uncontrolled bleeding is a leading cause of death during war, accidents and natural disasters [ [1] , [2] , [3] ]. As an imperative means of emergency hemostasis, prompt wound closure can effectively reduce blood loss and increase the chance of survival [ 4 , 5 ]. Clinically, suture and stapling have been the standard procedures for wound closure.…”