Multi-crosslinking hydrogels with robust bio-adhesion and pro-coagulant activity for first-aid hemostasis and infected wound healing

Zou, Chen-Yu; Lei, Xiongxin; Hu, Junmei; Jiang, Yanlin; Li, Qianjin; Song, Yuting; Zhang, Qingyi; Li‐Ling, Jesse; Xie, Huiqi

doi:10.1016/j.bioactmat.2022.02.034

Cited by 130 publications

(81 citation statements)

References 65 publications

(74 reference statements)

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“…2f showed that a higher rate of water uptake in the dried TA@GelMA hydrogel coating compared to the dried GelMA hydrogel and no significant differences were existed in the SRs between two wet hydrogel coating groups. Evidences [ 49 , 50 ] demonstrated that the faster swelling capacity of hydrogels coating endowed the complexes to concentrate coagulation factors in shorter time, which was more conducive to hemostasis. The freeze-dried hydrogel-mesh complexes, which are more suitable for storage in vacuum packages compared to wet complexes, can absorb water molecules in a very short time and convert them into wet complexes better for cell attachment and proliferation.…”

Section: Resultsmentioning

confidence: 99%

Tannic acid-loaded hydrogel coating endues polypropylene mesh with hemostatic and anti-inflammatory capacity for facilitating pelvic floor repair

Zhou²,

You

et al. 2022

Regenerative Biomaterials

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The application of polypropylene mesh (PPM) in pelvic organ prolapse (POP) treatment was severely limited by the complications associated with PPM, such as mesh exposure, chronic inflammatory reactions, and postoperative hematoma. This study applied a method of fabricating a hydrogel-mesh complex (PPM+TA@GelMA) to cross-link tannic acid (TA) directly with Methacrylate Gelatin (GelMA) hydrogel and thus to form a coating for polypropylene mesh. This one-step coating modification improved the hydrophilicity and cyto-compatibility of PPM. The hemostatic effect of PPM+TA@GelMA was confirmed through tail amputation test. Through the defect tissue repair experiments in vivo, it was proved that PPM+TA@GelMA had effects of anti-inflammation and promoting tissue repair, and regulated the M2 subtype macrophages polarization for tissue repair. The TA-loaded hydrogel coating endued PPM with multiple functions. It is believed that the novel hydrogel-mesh complex and its fabrication method will have great significance in basic research and clinical application.

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Section: Resultsmentioning

confidence: 99%

Tannic acid-loaded hydrogel coating endues polypropylene mesh with hemostatic and anti-inflammatory capacity for facilitating pelvic floor repair

Zhou²,

You

et al. 2022

Regenerative Biomaterials

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show abstract

“…PDA-HA [29][30][31] and NC hydrogels were synthesized, and their physicochemical properties were investigated. The gelation process is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

A Photothermal-Response Oxygen Release Platform Based on Hydrogel for Accelerating Wound Healing

Jin

et al. 2022

Preprint

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During wound healing, oxygen availability and anti-inflammatory microenvironment play an important role in the formation of new tissue. However, whether to provide continuous and controllable oxygen around the injured tissue while inhibiting inflammation, and realize the synergistic effect of oxygen supply and anti-inflammation, is still a major problem affecting the regeneration and repair of wound tissue. Inspired by skin wound pathology and the inflammatory microenvironment, a photothermal response-assisted strategy has been developed in this work. We prepared composite hydrogel system of PDA-HA (polydopamine-hyaluronic acid) hydrogel-loaded CaO2-ICG@LA@MnO2 (calcium peroxide-indocyanine green @ lauric acid @ manganese dioxide) nanoparticles, which showed excellent photothermal performance under near-infrared (NIR) irradiation, and realized the on-off release of oxygen and reactive oxygen species (ROS). Controlled and sustained oxygen release can promote the regeneration and repair of damaged tissue, and the generated ROS can effectively inhibit the outbreak of inflammation at the initial stage of wound healing. We believe that the system we have obtained can be used as a new approach for treating chronic wound healing.

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“…PDA-HA [35][36][37] and NC hydrogels were synthesized, and their physicochemical properties were investigated. The gelation process is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

A Photothermal-Response Oxygen Release Platform Based on Hydrogel for Accelerating Wound Healing

Jin

et al. 2022

Preprint

View full text Add to dashboard Cite

During wound healing, oxygen availability and anti-inflammatory microenvironment play an important role inthe formation of new tissue. However, whether to provide continuous and controllable oxygen around the injured tissue while inhibiting inflammation, and realize the synergistic effect of oxygen supply and anti-inflammation, is still a major problem affecting the regeneration and repair of wound tissue. Inspired by skin wound pathology and theinflammatory microenvironment, a photothermal response-assisted strategy has been developed in this work. We prepared composite hydrogel system of PDA-HA (polydopamine-hyaluronic acid)hydrogel-loaded CaO2-ICG@LA@MnO2(calcium peroxide-indocyanine green@lauric acid@manganese dioxide)nanoparticles, which showed excellent photothermal performanceunder near-infrared (NIR) irradiation, and realized the on-off release of oxygen and reactive oxygen species (ROS). Controlled and sustained oxygen release can promote the regeneration and repair of damaged tissue, and the generated ROS can effectively inhibit the outbreak of inflammation at the initial stage of wound healing. We believethat the system we have obtained can be used as a new approach for treating chronic wound healing.

show abstract

Multi-crosslinking hydrogels with robust bio-adhesion and pro-coagulant activity for first-aid hemostasis and infected wound healing

Cited by 130 publications

References 65 publications

Tannic acid-loaded hydrogel coating endues polypropylene mesh with hemostatic and anti-inflammatory capacity for facilitating pelvic floor repair

Tannic acid-loaded hydrogel coating endues polypropylene mesh with hemostatic and anti-inflammatory capacity for facilitating pelvic floor repair

A Photothermal-Response Oxygen Release Platform Based on Hydrogel for Accelerating Wound Healing

A Photothermal-Response Oxygen Release Platform Based on Hydrogel for Accelerating Wound Healing

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