Robotic stereotactic body radiotherapy in the treatment of sinonasal mucosal melanoma: Report of four cases

Abstract

Robotic SBRT seems to be an appealing treatment option for local control. Effective systemic treatment is required to prevent distant metastases.

Malignant melanoma of the nasal cavity treated with stereotactic radiotherapy using CyberKnife: report of 2 cases

“…Radiobiological studies demonstrated radio-resistant nature of the melanoma cells caused by the repair of sublethal DNA damage [4]. However, high dose per fraction may have a potential to control radio-resistant tumor [8][9][10]. Overgaard et al investigated the relationship between doses per fraction and response rate in 600 metastatic melanoma cases and reported that a cutoff value of 120 Gy, which was calculated as a biologically effective dose (BED), was associated with improved response rate [9].…”

“…Overgaard et al investigated the relationship between doses per fraction and response rate in 600 metastatic melanoma cases and reported that a cutoff value of 120 Gy, which was calculated as a biologically effective dose (BED), was associated with improved response rate [9]. Ozyigit et al reported that 4 cases of HNMM showed favorable outcomes with a total dose of 35 Gy in 5 fractions using CyberKnife® [10]. The relationship between doses per fraction and treatment outcome in the literature is summarized in Table 2.…”

Stereotactic radiotherapy with CyberKnife for a large angiosarcoma of the maxillary sinus: A case report

“…Recent reports have indicated the usefulness of these new techniques for the management of head and neck tumors [13][14][15][16][17][18]. The CyberKnife system is a robotic stereotactic radiosurgery/radiotherapy device that can deliver a high dose of radiation precisely and with minimal damage to surrounding tissue [19][20][21].…”

Single-fraction stereotactic body radiation therapy for sinonasal malignant melanoma

“…Horie et al reported a partial response with stereotactic radiosurgery (SRS) at a single fraction dose of 15 Gy. Ozyigit et al presented 4 sinonasal malignant melanoma cases that were treated with SBRT from 2007 to 2009, and all were alive by the time of publication in 2011. Doses used were 30 Gy in 3 fractions and 35 Gy in 5 fractions.…”