Single-fraction stereotactic body radiation therapy for sinonasal malignant melanoma

Abstract

These patients with sinonasal malignant melanoma achieved symptomatic relief of severe bleeding and airway issues from single-fraction SBRT. SBRT should be considered as a treatment option in patients with unresectable sinonasal malignant melanoma.

Development and Validation of a Clinically Relevant Workflow for MR-Guided Volumetric Arc Therapy in a Rabbit Model of Head and Neck Cancer

“…Despite the close association of the tumor to critical structures in the neck such as the trachea, spinal cord, and brain, a single high dose of 30 Gy was safely delivered under MR-guidance and resulted in a marked reduction in tumor volume. In recent years, highly conformal VMAT can be potentially delivered using a hypofractionated regimen for patients with recurrent disease following fractionated radiation [33]. We therefore evaluated our MR-guided RT approach using a single high dose to obtain proof-of-concept.…”

Radiotherapy alone as a method of treatment for sinonasal mucosal melanoma: A report based on six cases and a review of current opinion

“…The vast majority of SNMM patients receiving primary radiation therapy alone have advanced, inoperable tumors or are ineligible for surgery due to, e.g., their performance status or comorbidities; this group also includes patients who have not given their consent to surgical treatment. 4,5,7,14,16,17,[19][20][21][22][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] Four of our patients had inoperable tumors while two refused surgery. As in our group, most studies report a similar incidence between male and female SNMM patients 1,4,5,30,32 ; some researchers observe a slight male predominance.…”

“…One patient survived 7 years without any signs of the disease and the other achieved remission but developed a local relapse, which along with distant metastases led to the patient's death. 22 Christopherson et al (2015) used a dose of 45-70 Gy (conventional fractionation) and achieved local control in 2 out of 5 patients (40%) with SNMM. 34 It seems certain that primary radiotherapy in SNMM patients should at least be conducted using the IMRT technique.…”

“…4,5,7,14,17,18 In patients who are not eligible for primary surgical treatment, primary definitive or palliative radiotherapy is applied. 4,5,14,[17][18][19][20][21][22] The objective of our study was to present the outcomes of SNMM patients treated with primary radiotherapy alone, and analyse current views on the role of external radiotherapy as a definitive treatment modality for HNMM.…”

Cancers rares et nouvelles techniques de radiothérapie

“…La radiochirugie a donc permis le contrôle local de ces lésions. Bourgeois et al ont évalué l'intérêt de la radiochirurgie dans la prise en charge de deux cas de mélanomes muqueux nasosinusiens en récidive après une prise en charge chirurgicale [25]. Ces tumeurs agressives entraînent des épistaxis sévères et un effet de masse majeur.…”