Robbins BASIC PATHOLOGY

Kumar, Vinay; Abbas, Abul K.; Aster, Jon C.

doi:10.33029/9704-6467-0-krb-2022-1-1036

Cited by 502 publications

(812 citation statements)

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“…5-fluorouracil exhibited lower activity as a reference. Compound 58 increased the expression of BAX and decreased the amount of Bcl-2 both in DLD-1 and in HT-29 [48].…”

Section: Primary Anticancer Studiesmentioning

confidence: 95%

“…The role of the epidermal growth factor receptor (EGFR) in the pathogenesis process is an important topic of scientific research. As a result, it was discovered that mutations leading to overexpression of EGFR genes (e.g., increased regulation or amplification) are significantly associated with many cancers: lung granuloma (40% of cases), rectal tumors, glioblastoma (50%), and epithelial carcinomas of the head and neck (80-100%) [47,48].…”

Section: Epidermal Growth Factor Receptor Inhibitorsmentioning

confidence: 99%

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Recent Advances in the Biological Activity of s-Triazine Core Compounds

Maliszewski

Drozdowska

2022

Pharmaceuticals

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An effective strategy for successful chemotherapy relies on creating compounds with high selectivity against cancer cells compared to normal cells and relatively low cytotoxicity. One such approach is the discovery of critical points in cancer cells, i.e., where specific enzymes that are potential therapeutic targets are generated. Triazine is a six-membered heterocyclic ring compound with three nitrogen replacing carbon-hydrogen units in the benzene ring structure. The subject of this review is the symmetrical 1,3,5-triazine, known as s-triazine. 1,3,5-triazine is one of the oldest heterocyclic compounds available. Because of its low cost and high availability, it has attracted researcher attention for novel synthesis. s-Triazine has a weak base, it has much weaker resonance energy than benzene, therefore, nucleophilic substitution is preferred to electrophilic substitution. Heterocyclic bearing a symmetrical s-triazine core represents an interesting class of compounds possessing a wide spectrum of biological properties such as anti-cancer, antiviral, fungicidal, insecticidal, bactericidal, herbicidal and antimicrobial, antimalarial agents. They also have applications as dyes, lubricants, and analytical reagents. Hence, the group of 1,3,5-triazine derivatives has developed over the years. Triazine is not only the core amongst them, but is also a factor increasing the kinetic potential of the entire derivatives. Modifying the structure and introducing new substituents makes it possible to obtain compounds with broad inhibitory activity on processes such as proliferation. In some cases, s-triazine derivatives induce cell apoptosis. In this review we will present currently investigated 1,3,5-triazine derivatives with anti-cancer activities, with particular emphasis on their inhibition of enzymes involved in the process of tumorigenesis.

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“…5-fluorouracil exhibited lower activity as a reference. Compound 58 increased the expression of BAX and decreased the amount of Bcl-2 both in DLD-1 and in HT-29 [48].…”

Section: Primary Anticancer Studiesmentioning

confidence: 95%

Section: Epidermal Growth Factor Receptor Inhibitorsmentioning

confidence: 99%

Recent Advances in the Biological Activity of s-Triazine Core Compounds

Maliszewski

Drozdowska

2022

Pharmaceuticals

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“…Complex organisms, from plants to primates, require a well‐developed specific protective capacity to counteract noxious stimuli such as pathogen invasion, tissue damage, [ 1,2 ] and other kinds of hazard. [ 3 ] The initial host response triggered by these stimuli in vertebrates is inflammation, which is a localized dynamic process involving blood components, more specifically leukocytes and plasma proteins, together with tissue cells.…”

Section: Introductionmentioning

confidence: 99%

Sensing Inflammation Biomarkers with Electrolyte‐Gated Organic Electronic Transistors

Burtscher

Urbina

Diacci

et al. 2021

Adv Healthcare Materials

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An overview of cytokine biosensing is provided, with a focus on the opportunities provided by organic electronic platforms for monitoring these inflammation biomarkers which manifest at ultralow concentration levels in physiopathological conditions. Specifically, two of the field's state-of-the-art technologies-organic electrochemical transistors (OECTs) and electrolyte gated organic field effect transistors (EGOFETs)-and their use in sensing cytokines and other proteins associated with inflammation are a particular focus. The overview will include an introduction to current clinical and "gold standard" quantification techniques and their limitations in terms of cost, time, and required infrastructure. A critical review of recent progress with OECT-and EGOFET-based protein biosensors is presented, alongside a discussion onthe future of these technologies in the years and decades ahead. This is especially timely as the world grapples with limited healthcare diagnostics during the Coronavirus disease (COVID-19)pandemic where one of the worst-case scenarios for patients is the "cytokine storm." Clearly, low-cost point-of-care technologies provided by OECTs and EGOFETs can ease the global burden on healthcare systems and support professionals by providing unprecedented wealth of data that can help to monitor disease progression in real time.

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“…Gliomas are tumours of the brain parenchyma which are typically graded from I (low severity) to IV (high severity), and the five-year survival rates are 94% (for grade I) and 5% (for higher grades) [11]. Magnetic Resonance Imaging (MRI) has been widely used in examining gliomas during diagnosis, surgical planning and follow-up.…”

Section: Introductionmentioning

confidence: 99%

“…grading and sub-typing) and for high-grade cases histopathology examination is often required [6]. In histopathology, gliomas are classified based on the morphological features of the glial cells including increased cellularity, vascular proliferation, necrosis, and infiltration into normal brain parenchyma [11,17]. Oncologists examine patients' medical history, radiology scans, pathology slides and reports to provide suitable medical care for a person diagnosed with cancer.…”

Section: Introductionmentioning

confidence: 99%

Glioma Classification Using Multimodal Radiology and Histology Data

Hamidinekoo

Pieciak

Afzali

et al. 2020

Preprint

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Gliomas are brain tumours with a high mortality rate. There are various grades and sub-types of this tumour, and the treatment procedure varies accordingly. Clinicians and oncologists diagnose and categorise these tumours based on visual inspection of radiology and histology data. However, this process can be time-consuming and subjective. The computer-assisted methods can help clinicians to make better and faster decisions. In this paper, we propose a pipeline for automatic classification of gliomas into three sub-types: oligodendroglioma, astrocytoma, and glioblastoma, using both radiology and histopathology images. The proposed approach implements distinct classification models for radiographic and histologic modalities and combines them through an ensemble method. The classification algorithm initially carries out tile-level (for histology) and slice-level (for radiology) classification via a deep learning method, then tile/slice-level latent features are combined for a wholeslide and whole-volume sub-type prediction. The classification algorithm was evaluated using the data set provided in the CPM-RadPath 2020 challenge. The proposed pipeline achieved the F1-Score of 0.886, Cohen's Kappa score of 0.811 and Balance accuracy of 0.860. The ability of the proposed model for end-to-end learning of diverse features enables it to give a comparable prediction of glioma tumour sub-types.

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Robbins BASIC PATHOLOGY

Cited by 502 publications

References 0 publications

Recent Advances in the Biological Activity of s-Triazine Core Compounds

Recent Advances in the Biological Activity of s-Triazine Core Compounds

Sensing Inflammation Biomarkers with Electrolyte‐Gated Organic Electronic Transistors

Glioma Classification Using Multimodal Radiology and Histology Data

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