Roadmap for single-molecule surface-enhanced Raman spectroscopy

Yu, Yang; Xiao, Ting‐Hui; Wu, Yunzhao; Li, Wan-Jun; Zeng, Qing-Guang; Li, Long; Li, Zhiyuan

doi:10.1117/1.ap.2.1.014002

Cited by 90 publications

(42 citation statements)

References 102 publications

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“…However, these studies used plasmonic pulses only as the trapping source. motivated important applications in many fields, such as enhanced Raman scattering spectroscopy [218][219][220] . Here, the high peak intensity of a pulsed surface plasmon can contribute to other potential nonlinear optical processes, such as the multiple-photon interaction process [221][222][223] .…”

Section: Trapping By Plasmonic Pulsesmentioning

confidence: 99%

Plasmonic tweezers: for nanoscale optical trapping and beyond

et al. 2021

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Optical tweezers and associated manipulation tools in the far field have had a major impact on scientific and engineering research by offering precise manipulation of small objects. More recently, the possibility of performing manipulation with surface plasmons has opened opportunities not feasible with conventional far-field optical methods. The use of surface plasmon techniques enables excitation of hotspots much smaller than the free-space wavelength; with this confinement, the plasmonic field facilitates trapping of various nanostructures and materials with higher precision. The successful manipulation of small particles has fostered numerous and expanding applications. In this paper, we review the principles of and developments in plasmonic tweezers techniques, including both nanostructure-assisted platforms and structureless systems. Construction methods and evaluation criteria of the techniques are presented, aiming to provide a guide for the design and optimization of the systems. The most common novel applications of plasmonic tweezers, namely, sorting and transport, sensing and imaging, and especially those in a biological context, are critically discussed. Finally, we consider the future of the development and new potential applications of this technique and discuss prospects for its impact on science.

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Section: Trapping By Plasmonic Pulsesmentioning

confidence: 99%

Plasmonic tweezers: for nanoscale optical trapping and beyond

et al. 2021

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“…To demonstrate this 2-D spatiotemporal FT method for on-chip devices, we chose surface plasmon polaritons (SPP) excited on a metal surface as carriers of on-chip optical signals, and studied modulation effects of femtosecond SPP pulses. With their capability of breaking through the optical diffraction limit 12 , SPPs are widely employed in nanophotonic devices used in a variety of applications including optical storage 13 , optical sensing 14 , optical tweezers 15 , and Raman scattering 16 . In addition to nanoscale spatial resolutions, SPP pulses generated by a femtosecond laser beam enable femtosecond-scale temporal resolutions, thereby providing a research platform to investigate the manipulation of light fields and the interaction of light and matter at extremely small spatiotemporal scales.…”

Section: / 14mentioning

confidence: 99%

Two-dimensional spatiotemporal Fourier transform with femtosecond pulses for on-chip devices

Wang

Min

Zhang

et al. 2021

Preprint

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On-chip manipulation of the spatiotemporal characteristics of optical signals is important in the transmission and processing of information. However, the simultaneous modulation of on-chip optical pulses, both spatially at the nano-scale and temporally over ultra-fast intervals, is challenging. Here, we propose a two-dimensional spatiotemporal Fourier transform (FT) method for on-chip control of the propagation of femtosecond optical pulses and verify this method employing surface plasmon polariton (SPP) pulses on metal surface. By varying space- and frequency-dependent parameters, we demonstrate that the traditional SPP focal spot may be bent into a ring shape, and that the direction of propagation of a curved SPP-Airy beam may be reversed at certain moments to create an S-shaped path. Compared with conventional spatial modulation of SPPs, this method offers potentially a variety of extraordinary effects in SPP modulation especially associated with the temporal domain, thereby providing a new platform for on-chip spatiotemporal manipulation of optical pulses with applications including ultrafast on-chip photonic information processing, ultrafast pulse/beam shaping, and optical computing.

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“…The SERS showed high sensitivity that allowed its application in single molecule level detections [31], used in DNA detection [32]. A thermoplasmonics SARS CoV-2 detection system was recently developed from SERS (Figure 2) [33]. In that work, a Plasmonic Photothermal (PPT) was combined with Localized Surface Plasmon Resonance (LSPR) sensing.…”

Section: In Addition Their Incorporation Into Different Opticalmentioning

confidence: 99%

Detection of Viruses and development of new treatments: Insights into Antibody-Antigen Interactions and Multifunctional Lab-On-Particle for SARS CoV-2

2021

J Nanotechnol Nanomaterials

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The design of new drugs, molecules, nano-, and microstructures for targeted applications is of high impact in Life Sciences. In this context, and mainly for the Corona Virus Pandemic, a fast response is highly required. Thus, the developments of novel approaches are urgently need, seeking improved and highly sensitive solutions in the field of bio detection, in addition to new treatments of SARS CoV-2. In this manner, this short communication discusses the following topics: i) the importance of non-covalent interactions from antibody-antigen recognition events; ii) the genomic factor from virus towards interactions and infections; iii) the importance of the non-covalent interactions on optical detection systems, and iv) the development of new approaches of detection and new treatments based on Smart Responsive Multifunctional Nano-, Microparticles and lab-on particles too. Moreover, it was analyzed the current state of the COVID-19 pandemic, the importance of new treatments in progress and the development of new vaccines and alternative treatments. As well, it is discussed the improvement of highly sensitive and innovative multifunctional Nanophotonic approaches for SARS CoV-2 detection and potential targeted treatments based on non-classical light delivery.

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Roadmap for single-molecule surface-enhanced Raman spectroscopy

Cited by 90 publications

References 102 publications

Plasmonic tweezers: for nanoscale optical trapping and beyond

Plasmonic tweezers: for nanoscale optical trapping and beyond

Two-dimensional spatiotemporal Fourier transform with femtosecond pulses for on-chip devices

Detection of Viruses and development of new treatments: Insights into Antibody-Antigen Interactions and Multifunctional Lab-On-Particle for SARS CoV-2

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