2007
DOI: 10.1096/fj.06-6155com
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Abstract: Recent observations demonstrated that translation of mRNAs may occur in axonal processes at sites that are long distances away from the neuronal perikaria. While axonal protein synthesis has been documented in several studies, the mechanism of its regulation remains unclear. The aim of this study was to investigate whether RNA interference (RNAi) may be one of the pathways that control local protein synthesis in axons. Here we show that sciatic nerve contains Argonaute2 nuclease, fragile X mental retardation p… Show more

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Cited by 86 publications
(71 citation statements)
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“…We have previously demonstrated that FMRP is transported to the peripheral axons of rat nociceptors (Price et al, 2006). It is also known that FMRP localizes to axonal growth cones, where it is involved in regulating axonal growth (Antar et al, 2006), and that FMRP is associated with RNAi machinery in sensory axons (Murashov et al, 2007). Here, we have shown that intraplantar rapamycin inhibited second-phase formalin responses in wild-type but not KO mice, demonstrating a role for peripheral mTOR-mediated translation in this model.…”
Section: Discussionmentioning
confidence: 59%
“…We have previously demonstrated that FMRP is transported to the peripheral axons of rat nociceptors (Price et al, 2006). It is also known that FMRP localizes to axonal growth cones, where it is involved in regulating axonal growth (Antar et al, 2006), and that FMRP is associated with RNAi machinery in sensory axons (Murashov et al, 2007). Here, we have shown that intraplantar rapamycin inhibited second-phase formalin responses in wild-type but not KO mice, demonstrating a role for peripheral mTOR-mediated translation in this model.…”
Section: Discussionmentioning
confidence: 59%
“…6). However, it has also been well documented that RNAi machinery exists in the peripheral nerve axons (57,58). Therefore, siRNA-mediated degradation of NaV1.8 mRNA could also occur in peripheral axons.…”
Section: Discussionmentioning
confidence: 99%
“…This method to utilize axonal protein synthesis is complemented by the possibility of using RNA interference (RNAi) in axons to deplete selectively axons of specific mRNAs without changing the mRNA's abundance in other parts of the neurons. The RNAi is present and functional in developing axons of cultured dorsal root ganglion and superior cervical neurons [91,92], and in sciatic nerves [93]. More recently, we have found that injection of small interfering RNA (siRNA) into in the brain of adult mice can be used to deplete axons of mRNA [45].…”
Section: Toolsmentioning
confidence: 99%