RNAi and miRNA in Viral Infections and Cancers

Mollaie, Hamid Reza; Monavari, Seyed Hamid Reza; Arabzadeh, Seyed Ali Mohammad; Shamsi-Shahrabadi, M; Fazlalipour, Mehdi; Afshar, Reza Malekpour

doi:10.7314/apjcp.2013.14.12.7045

Cited by 28 publications

(26 citation statements)

References 112 publications

(113 reference statements)

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“…Furthermore, therapeutic approaches involving the re-introduction of miRNAs lost in cancer or inhibition of oncogenic miRNAs are rapidly being developed. Additionally, the antisense technology based on antagomiRs which can inhibit the activity of oncogenic miRNAs, is the major method used to reduce unwanted miRNA expression in tumor cells (Mollaie et al, 2013). Recently Xu et al (2012) reported that multitarget anti-microRNA antisense oligonucleotide (MTgAMOs) can specifically inhibit the expression of multiple miRNAs, and effectively antagonize proliferation and migration of gastric cancer cells promoted by oncomirs.…”

Section: Micrornas As Potential Biomarkers For Cancer Diagnosis and Pmentioning

confidence: 99%

MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis

Kavitha¹,

Vijayarathna²,

Jothy³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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MicroRNAs (miRNAs) are short non-coding RNAs of 20-24 nucleotides that play important roles in carcinogenesis. Accordingly, miRNAs control numerous cancer-relevant biological events such as cell proliferation, cell cycle control, metabolism and apoptosis. In this review, we summarize the current knowledge and concepts concerning the biogenesis of miRNAs, miRNA roles in cancer and their potential as biomarkers for cancer diagnosis and prognosis including the regulation of key cancer-related pathways, such as cell cycle control and miRNA dysregulation. Moreover, microRNA molecules are already receiving the attention of world researchers as therapeutic targets and agents. Therefore, in-depth knowledge of microRNAs has the potential not only to identify their roles in cancer, but also to exploit them as potential biomarkers for cancer diagnosis and identify therapeutic targets for new drug discovery.

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Section: Micrornas As Potential Biomarkers For Cancer Diagnosis and Pmentioning

confidence: 99%

MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis

Kavitha¹,

Vijayarathna²,

Jothy³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Among the all types of ncRNAs, microRNAs (miRNAs) received the greatest attention due to their frequent dys-regulations in CRC. miRNAs compromise a large subsequent of endogenous small ncRNAs that regulate gene expression posttranscriptionally and control various cellular mechanisms including tissue development (Johnston and Hobert, 2003;Zhao et al, 2005), cell proliferation (Cheng et al, 2005;, cell division (Hatfield et al, 2005;Croce and Calin, 2005), cell differentiation (Naguibneva et al, 2006), neuronal asymmetry (Bartel, 2004), metabolism (Filipowicz, 2005), stem cell properties (JamshidiAdegani et al, 2014), apoptosis (Matsushima et al, 2011), protein secretion (Poy et al, 2004) and viral infection (Mollaie et al, 2013). Each individual miRNA predicted to target multiple mRNAs based on the seed sequence matches in their 3'-UTRs and vice versa a single mRNA may be targeted by several miRNAs and have diverse outcomes (Lewis et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs in Colorectal Cancer: from Diagnosis to Targeted Therapy

Orang¹,

Barzegari²

2014

Asian Pacific Journal of Cancer Prevention

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Colorectal cancer (CRC) is one of the major healthcare problems worldwide and its processes of genesis include a sequence of molecular pathways from adenoma to carcinoma. The discovery of microRNAs, a subset of regulatory non-coding RNAs, has added new insights into CRC diagnosis and management. Together with several causes of colorectal neoplasia, aberrant expression of oncomiRs (oncogenic and tumor suppressor miRNAs) in cancer cells was found to be indirectly result in up-or down-regulation of targeted mRNAs specific to tumor promoter or inhibitor genes. The study of miRNAs as CRC biomarkers utilizes expression profiling methods from traditional tissue samples along with newly introduced non-invasive samples of faeces and body fluids. In addition, miRNAs could be employed to predict chemo-and radio-therapy responses and be manipulated in order to alleviate CRC characteristics. The scope of this article is to provide a comprehensive review of scientific literature describing aberrantly expressed miRNAs, and consequently dysregulation of targeted mRNAs along with the potential role of miRNAs in CRC diagnosis and prognosis, as well as to summarize the recent findings on miRNA-based manipulation methods with the aim of advancing in anti-CRC therapies.

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“…miRNAs have been extensively studied regulators in molecular oncology and it is now evident that tumor suppressor miRNAs are repressed/downregulated and oncogenic miRNAs are overexpressed in cancer cells (Farooqi et al, 2014;Mollaie et al, 2013;Orang et al, 2014). Differential expression of miRNAs has been studied in different cancers and high-throughput technologies have added new layers of information into the existing pool of knowledge (Ding et al, 2014;Diao et al, 2014).…”

Section: Mirna Response Element Controlled Expression Of Trailmentioning

confidence: 99%